Asthma and Pregnancy – Comorbid and Coexisting

Asthma is considered the most common serious medical problem that could complicate pregnancy. During pregnancy the severity of asthma often changes, hence the patients need close follow up and monitoring exacerbations

Sensitization to indoor aeroallergens in children who attended the Allergy Service of the “Dr. José Eleuterio González” University Hospital of Monterrey, Mexico

Background: Indoor aeroallergens are the main cause of sensitization in children and represent a risk factor for the development of allergic diseases. Objective: Identify the major indoor aeroallergens most often sensitized to pediatric patients treated at the Allergy Service at the “Dr. José Eleuterio González” University Hospital of Monterrey Methods: We performed an observational and descriptive study where we reviewed reports of positive skin tests to the following common indoor aeroallergens: Dermatophagoides farinae (D. farinae), Dermatophagoides pteronyssinus (D. pteronyssinus), Canis familiaris (C. familiaris), Felis domesticus (F. domesticus), Blattella germanica (B. germanica) and Periplaneta americana (P. americana), found in patients under 16 years with symptoms of allergy, during the period of 2011-2012. Results: We performed 439 skin tests to aeroallergens in pediatric patients. Of these, 57.6% were male and 42.4% were female. Mean age was 6.3 years. The age groups were under 3 years: 17.8%, 3-5 years: 35%, 6-12 years: 36%, and 13-16 years: 11.2%. The main diagnoses were: allergic rhinitis (71.8%), asthma (16.6%), and atopic dermatitis (4.3%). In 57.9% of the cases, they had at least one positive skin test to any aeroallergen. The rate of sensitization to speciic aeroallergens was: D. Pteronyssinus 49.0%, D. farinae 44.6%, B. germanica 13.9%, P. Americana 10.9%, F. domesticus 10.7%, and C. familiaris 5.9%. Conclusion: Indoor aeroallergen sensitization can occur early in life, although it was more frequent in the preschooler and elementary school group. Dust house mites were the most commom cause of allergic sensitization

Dental and Maxillofacial Alterations in Children with Allergic Rhinitis Attended at the University Hospital of Monterrey, Mexico

La rinitis alérgica es una de las principales causas de la respiración orall y diferentes estudios en niños han reportado un aumento en la incidencia de caries dental, alteraciones maxilares y alteraciones morfológicas orofaciales. El objetivo de este estudio fue determinar la prevalencia de alteraciones dentales y maxilofaciales en niños con rinitis alérgica del noreste de México

Asociación de la eosinofilia nasal con alteración en las pruebas de función pulmonar en pacientes con rinitis alérgica persistente moderada-grave

Conocer el impacto de la eosinofilia nasal en pacientes con rinitis alérgica (rA) persistente moderada-grave, sobre la función pulmonar. ABSTRACT To understand the impact of nasal eosinophilia in patients with moderate to severe persistent allergic rhinitis over lung function, determined by the value of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and the presence or absence of reversibility FEV1 greater than 12%

Sensibilización a alérgenos alimentarios en pacientes del Servicio de Alergia del Hospital Universitario de la UANL, Monterrey

La alergia a alimentos ocurre en 2% a 8% de la población. La sensibilización a los alérgenos alimentarios puede ser detectada mediante pruebas cutáneas (PC). Objetivo: Evaluar la frecuencia de sensibilización a alérgenos alimentarios, en pacientes menores de 18 años, atendidos en el Servicio de Alergia del Hospital Universitario de Monterrey. ABSTRACT Food allergy occurs between 2%-8% of the population and sensitization to food allergens is detected by skin prick test (SPT). Objective: To assess the frequency of sensitization to food allergens in patients less than 18 years old attended in the Allergy Service of the University Hospital of the UANL in Monterrey

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Prevalencia de trastornos dentomaxilofaciales en niños con rinitis alérgica que acuden a la consulta del Centro Regional de Alergia e Inmunología Clínica del Hospital Universitario "Dr. José E. González (abs)

La rinitis alérgica es el tipo mas común de rinitis crónica y una de las principales causas de respiración oral en niños. Existen pocos estudios que determinen las alteraciones dentomaxilofaciales en niños con rinitis alérgica y respiración oral