Una nueva herramienta para valorar la calidad de vida de pacientes con artritis reumatoidea que no requiere licencia: el cuestionario QOL-RA II (Quality Of Life-Rheumatoid Arthritis Scale-II)

Recientemente, validamos el cuestionario Quality of Life-Rheumatoid Arthritis Scale (QOL-RA) y detectamos la presencia de algunas limitaciones. Por esta razón, con la autorización de la autora, cambiamos dos preguntas y desarrollamos una nueva versión en español: el QOL-RA II. Objetivo: validar el QOL-RA II en una cohorte argentina de pacientes con Artritis Reumatoidea (AR). Material y métodos: estudio de corte transversal. Se incluyeron pacientes ≥18 años de edad, con diagnóstico de AR según criterios ACR-EULAR 2010. Se consignaron datos sociodemográficos, comorbilidades, características clínicas y actividad de la enfermedad. Se administraron los cuestionarios EQ-5D-3L, QOL-RA II, HAQ-A y PHQ-9. A 20 pacientes se les re-administró el cuestionario a los 7 días de haber completado el primero para evaluar reproducibilidad

Asociación entre Artritis Reumatoidea y otras enfermedades autoinmunes

Objetivos: determinar la frecuencia de enfermedades autoinmunes (EAI) en pacientes con Artritis Reumatoidea (AR) y comparar la frecuencia de EAI entre pacientes con AR y sin AR ni otra EAI reumatológica. Material y Métodos: estudio multicéntrico, observacional, analítico, retrospectivo. Se incluyeron pacientes consecutivos con AR (ACR/EULAR 2010) y como grupo control pacientes con diagnóstico inicial de Osteoartritis primaria (OA).

Acylated Flavonoid Glycosides are the Main Pigments that Determine the Flower Colour of the Brazilian Native Tree <i>Tibouchina pulchra</i> (Cham.) Cogn.

Tibouchina pulchra (Cham.) Cogn. is a plant native to Brazil whose genus and family (Melastomataceae) are poorly studied with regards to its metabolite profile. Phenolic pigments of pink flowers were studied by ultra-performance liquid chromatography with a photodiode array detector and electrospray ionization quadrupole time-of-flight mass spectrometry. Therein, twenty-three flavonoids were identified with eight flavonols isolated by preparative high-performance liquid chromatography and analysed by one- and two-dimensional nuclear magnetic resonance. Kaempferol derivatives were the main flavonols, encompassing almost half of the detected compounds with different substitution patterns, such as glucoside, pentosides, galloyl-glucoside, p-coumaroyl-glucoside, and glucuronide. Concerning the anthocyanins, petunidin p-coumaroyl-hexoside acetylpentoside and malvidin p-coumaroyl-hexoside acetylpentoside were identified and agreed with previous reports on acylated anthocyanins from Melastomataceae. A new kaempferol glucoside was identified as kaempferol-(2&#8242;&#8242;-O-methyl)-4&#8242;-O-&#945;-d-glucopyranoside. Moreover, twelve compounds were described for the first time in the genus with five being new to the family, contributing to the chemical characterisation of these taxa

Genetic heterogeneity of two bioeconomically important kelp species along the Norwegian coast

Knowledge of genetic diversity among wild populations is becoming increasingly important as more species are recognized for their bioeconomic value. Industrialization of natural resources, such as kelp in the marine shallow sublittoral zone through cultivation and wild-harvesting, may lead to extensive translocation and local population decimation. Without adequate resilience in the form of genetic diversity within and across populations and given the potential introduction of deleterious alleles from translocations, such anthropogenically pressured populations may not be able to sufficiently respond to future climate and other stressors. Here we provide an assessment of the genetic heterogeneity of two bioeconomically important kelp species, Laminaria hyperborea and Saccharina latissima, across the Norwegian coastal region from South (57°N) to North (78°N), by applying microsatellite genotyping. Isolation by distance was found for both kelp species when comparing genetic distance to geographic distance. L. hyperborea clustered into four distinct genetic groups corresponding to distinct geographical ecoregions, whereas S. latissima did not show equally strong geographical structuring but separated into three geographical clusters along the Norwegian coast. No genetic differentiation was found within the Norwegian Skagerrak region, corroborating previous findings. The identified genetic clustering of both kelp species supports the retention of established management regions along the Norwegian coast and argues for the continuation of a regional focused management plan for kelp resources. Further, the results demonstrate that care should be taken to prevent translocation of kelp between ecoregions in the ongoing industrialization of kelp cultivation, to maintain a healthy coastal ecosystem and sound natural population genetic diversity

Genetic heterogeneity of two bioeconomically important kelp species along the Norwegian coast

Knowledge of genetic diversity among wild populations is becoming increasingly important as more species are recognized for their bioeconomic value. Industrialization of natural resources, such as kelp in the marine shallow sublittoral zone through cultivation and wild-harvesting, may lead to extensive translocation and local population decimation. Without adequate resilience in the form of genetic diversity within and across populations and given the potential introduction of deleterious alleles from translocations, such anthropogenically pressured populations may not be able to sufficiently respond to future climate and other stressors. Here we provide an assessment of the genetic heterogeneity of two bioeconomically important kelp species, Laminaria hyperborea and Saccharina latissima, across the Norwegian coastal region from South (57°N) to North (78°N), by applying microsatellite genotyping. Isolation by distance was found for both kelp species when comparing genetic distance to geographic distance. L. hyperborea clustered into four distinct genetic groups corresponding to distinct geographical ecoregions, whereas S. latissima did not show equally strong geographical structuring but separated into three geographical clusters along the Norwegian coast. No genetic differentiation was found within the Norwegian Skagerrak region, corroborating previous findings. The identified genetic clustering of both kelp species supports the retention of established management regions along the Norwegian coast and argues for the continuation of a regional focused management plan for kelp resources. Further, the results demonstrate that care should be taken to prevent translocation of kelp between ecoregions in the ongoing industrialization of kelp cultivation, to maintain a healthy coastal ecosystem and sound natural population genetic diversity.submittedVersio