Pressure Effect on ERG and Optic Nerve Conduction of Visual Impulse: Short-Term Effects in Owl Monkeys

The effects of increased intraocular pressure on optic tract responses and the electroretinogram (ERG) b-wave were studied in owl monkeys. Both responses showed a decrease in amplitude only if the intraocular pressures exceeded a certain critical level, which was about 30 mm Hg below mean femoral blood pressure. Above this intraocular pressure, the magnitude of the depressed ERG and optic tract responses were linearly related to the perfusion pressure. The maximum effect occurred within five minutes, and after the intraocular pressure was restored to normal, the optic tract response and ERG returned to normal in four to five minutes. It is not clear whether the phenomena studied here have any relationship to the optic nerve damage seen in chronic open-angle glaucoma, where the perfusion pressure is usually greater than 30 mm Hg

Patients beware: commercialized stem cell treatments on the web

A report by the International Society for Stem Cell Research (ISSCR)'s Task Force on Unproven Stem Cell Treatments outlines development of resources for patients, their families, and physicians seeking information on stem cell treatments.Fil: Taylor, Patrick L.. Children’s Hospital Boston; Estados UnidosFil: Barker, Roger A.. University of Cambridge. Department of Clinical Neuroscience. Cambridge Centre for Brain Repair; Reino UnidoFil: Blume, Karl G.. University Of Stanford; Estados UnidosFil: Cattaneo, Elena. Universita Degli Studi Di Milano; ItaliaFil: Colman, Alan. A*STAR Singapore Stem Cell Consortium; SingapurFil: Deng, Hongkui. Peking University; República de ChinaFil: Edgar, Harold. Columbia Law School; Estados UnidosFil: Fox, Ira J.. Children’s Hospital of Pittsburgh of UPMC. McGowan Institute for Regenerative Medicine; Estados UnidosFil: Gerstle, Claude. Delray Beach; Estados UnidosFil: Goldstein, Lawrence S. B.. University Of California At San Diego; Estados UnidosFil: High, Katherine A.. The Children’s Hospital of Philadelphia; Estados UnidosFil: Lyall, Andrew. Stem Cell Network; CanadáFil: Parkman, Robertson. Children’s Hospital Los Angeles; Estados UnidosFil: Pitossi, Fernando Juan. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; ArgentinaFil: Prentice, Ernest D.. University of Nebraska Medical Center; Estados UnidosFil: Rooke, Heather M.. International Society for Stem Cell Research; Estados UnidosFil: Sipp, Douglas A.. RIKEN Center for Developmental Biology; JapónFil: Srivastava, Alok. Christian Medical College; IndiaFil: Stayn, Susan. University Of Stanford; Estados UnidosFil: Steinberg, Gary K.. University Of Stanford; Estados UnidosFil: Wagers, Amy J.. Joslin Diabetes Center; Estados UnidosFil: Weissman, Irving L.. University Of Stanford; Estados Unido

New ISSCR Guidelines Underscore Major Principles for Responsible Translational Stem Cell Research

10.1016/j.stem.2008.11.009Cell Stem Cell36607-60