3,147 research outputs found
The Gemini NICI Planet-Finding Campaign
Our team is carrying out a multi-year observing program to directly image and
characterize young extrasolar planets using the Near-Infrared Coronagraphic
Imager (NICI) on the Gemini-South 8.1-meter telescope. NICI is the first
instrument on a large telescope designed from the outset for high-contrast
imaging, comprising a high-performance curvature adaptive optics system with a
simultaneous dual-channel coronagraphic imager. Combined with state-of-the-art
observing methods and data processing, NICI typically achieves ~2 magnitudes
better contrast compared to previous ground-based or space-based programs, at
separations inside of ~2 arcsec. In preparation for the Campaign, we carried
out efforts to identify previously unrecognized young stars, to rigorously
construct our observing strategy, and to optimize the combination of angular
and spectral differential imaging. The Planet-Finding Campaign is in its second
year, with first-epoch imaging of 174 stars already obtained out of a total
sample of 300 stars. We describe the Campaign's goals, design, implementation,
performance, and preliminary results. The NICI Campaign represents the largest
and most sensitive imaging survey to date for massive (~1 Mjup) planets around
other stars. Upon completion, the Campaign will establish the best measurements
to date on the properties of young gas-giant planets at ~5-10 AU separations.
Finally, Campaign discoveries will be well-suited to long-term orbital
monitoring and detailed spectrophotometric followup with next-generation
planet-finding instruments.Comment: Proceedings of the SPIE, vol 7736 (Advances in Adaptive Optics, San
Diego, CA, June 2010 meeting), in pres
Twelve weeks of supervised exercise improves self-reported symptom burden and fatigue in chronic kidney disease : a secondary analysis of the âExTra CKDâ trial
Background
Chronic kidney disease (CKD) patients experience a high symptom burden including fatigue, sleep difficulties, muscle weakness and pain. These symptoms reduce levels of physical function (PF) and activity, and contribute to poor health-related quality of life (HRQoL). Despite the gathering evidence of positive physiological changes following exercise in CKD, there is limited evidence on its effect on self-reported symptom burden, fatigue, HRQoL and physical activity.
Methods
Thirty-six patients [meanâ±âSD 61.6â±â11.8âyears, 22 (61%) females, estimated glomerular filtration rate: 25.5â±â7.8âmL/min/1.73 m2] not requiring renal replacement therapy underwent 12 weeks (3 times/week) of supervised aerobic exercise (AE), or a combination (CE) of AE plus resistance training. Outcomes included self-reported symptom burden, fatigue, HRQoL and physical activity.
Results
Exercise reduced the total number of symptoms reported by 17% and had favourable effects on fatigue in both groups. AE reduced the frequency of âitchingâ, âimpotenceâ and âshortness of breathâ symptoms, and the intrusiveness for symptoms of âsleep disturbanceâ, âloss of muscular strength/powerâ, âmuscle spasm/stiffnessâ and ârestless legsâ. The addition of resistance exercise in the CE group saw a reduction in âloss of muscular strength/powerâ. No changes were seen in subjective PF or physical activity levels. AE increased self-efficacy for physical activity.
Conclusions
Supervised exercise had favourable effects on symptom frequency and intrusiveness, including substantial improvements in fatigue. Although the intervention did not improve self-reported physical activity levels, AE increased patientsâ self-efficacy for physical activity. These favourable changes in self-reported outcomes support the important role of exercise in CKD
Parodie et carnavalisation : lâexemple de Hubert Aquin
One of the defining features of patient-centered outcomes research (PCOR) is the emphasis on reporting outcomes that are meaningful to patients. Accelerating progress toward this objective could be achieved through increased development and uptake of core outcome sets (COS), which are intended to represent a standardized minimum set of outcomes that should bemeasured and reported in all clinical trials in a specific condition. The level of activity around COS has increased significantly over recent years, however there are many important clinical conditions for which high quality COS havenot been developed. We believe that meaningful progress toward the goals behind the significant investments in PCOR will depend on sustained attention to the challenges of COS development and uptake
The association of physical function and physical activity with all-cause mortality and adverse clinical outcomes in non-dialysis chronic kidney disease : a systematic review
Objective:
People with nondialysis-dependent chronic kidney disease (CKD) and renal transplant recipients (RTRs) have compromised physical function and reduced physical activity (PA) levels. Whilst established in healthy older adults and other chronic diseases, this association remains underexplored in CKD. We aimed to review the existing research investigating poor physical function and PA with clinical outcome in nondialysis CKD.
Data sources:
Electronic databases (PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials) were searched until December 2017 for cohort studies reporting objective or subjective measures of PA and physical function and the associations with adverse clinical outcomes and all-cause mortality in patients with nondialysis CKD stages 1â5 and RTRs. The protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42016039060).
Review methods:
Study quality was assessed using the Newcastle-Ottawa Scale and the Agency for Healthcare and Research Quality (AHRQ) standards.
Results:
A total of 29 studies were included; 12 reporting on physical function and 17 on PA. Only eight studies were conducted with RTRs. The majority were classified as âgoodâ according to the AHRQ standards. Although not appropriate for meta-analysis due to variance in the outcome measures reported, a coherent pattern was seen with higher mortality rates or prevalence of adverse clinical events associated with lower PA and physical function levels, irrespective of the measurement tool used. Sources of bias included incomplete description of participant flow through the study and over reliance on self-report measures.
Conclusions:
In nondialysis CKD, survival rates correlate with greater PA and physical function levels. Further trials are required to investigate causality and the effectiveness of physical function and PA interventions in improving outcomes. Future work should identify standard assessment protocols for PA and physical function
The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis
Summary:
Expression of the initiator methionine tRNA (tRNAi
Met)
is deregulated in cancer. Despite this fact, it is not
currently known how tRNAi
Met expression levels influence
tumor progression. We have found that tRNAi
Met
expression is increased in carcinoma-associated
fibroblasts, implicating deregulated expression of
tRNAi
Met in the tumor stroma as a possible contributor
to tumor progression. To investigate how elevated
stromal tRNAi
Met contributes to tumor progression,
we generated a mouse expressing additional copies
of the tRNAi
Met gene (2+tRNAi
Met mouse). Growth
and vascularization of subcutaneous tumor allografts
was enhanced in 2+tRNAi
Met mice compared with
wild-type littermate controls. Extracellular matrix
(ECM) deposited by fibroblasts from 2+tRNAi
Met
mice supported enhanced endothelial cell and fibroblast
migration. SILAC mass spectrometry indicated
that elevated expression of tRNAi
Met significantly
increased synthesis and secretion of certain types of
collagen, in particular type II collagen. Suppression
of type II collagen opposed the ability of tRNAi
Metoverexpressing
fibroblasts to deposit pro-migratory
ECM. We used the prolyl hydroxylase inhibitor ethyl-
3,4-dihydroxybenzoate (DHB) to determine whether
collagen synthesis contributes to the tRNAi
Met-driven
pro-tumorigenic stroma in vivo. DHB had no effect
on the growth of syngeneic allografts in wild-type
mice but opposed the ability of 2+tRNAi
Met mice to
support increased angiogenesis and tumor growth.
Finally, collagen II expression predicts poor prognosis
in high-grade serous ovarian carcinoma. Taken
together, these data indicate that increased tRNAi
Met
levels contribute to tumor progression by enhancing
the ability of stromal fibroblasts to synthesize and
secrete a type II collagen-rich ECM that supports
endothelial cell migration and angiogenesis
Terrestrial Planet Occurrence Rates for the Kepler GK Dwarf Sample
We measure planet occurrence rates using the planet candidates discovered by
the Q1-Q16 Kepler pipeline search. This study examines planet occurrence rates
for the Kepler GK dwarf target sample for planet radii, 0.75<Rp<2.5 Rearth, and
orbital periods, 50<Porb<300 days, with an emphasis on a thorough exploration
and identification of the most important sources of systematic uncertainties.
Integrating over this parameter space, we measure an occurrence rate of F=0.77
planets per star, with an allowed range of 0.3<F<1.9. The allowed range takes
into account both statistical and systematic uncertainties, and values of F
beyond the allowed range are significantly in disagreement with our analysis.
We generally find higher planet occurrence rates and a steeper increase in
planet occurrence rates towards small planets than previous studies of the
Kepler GK dwarf sample. Through extrapolation, we find that the one year
orbital period terrestrial planet occurrence rate, zeta_1=0.1, with an allowed
range of 0.01<zeta_1<2, where zeta_1 is defined as the number of planets per
star within 20% of the Rp and Porb of Earth. For G dwarf hosts, the zeta_1
parameter space is a subset of the larger eta_earth parameter space, thus
zeta_1 places a lower limit on eta_earth for G dwarf hosts. From our analysis,
we identify the leading sources of systematics impacting Kepler occurrence rate
determinations as: reliability of the planet candidate sample, planet radii,
pipeline completeness, and stellar parameters.Comment: 19 Pages, 17 Figures, Submitted ApJ. Python source to support Kepler
pipeline completeness estimates available at
http://github.com/christopherburke/KeplerPORTs
Aeolianâlacustrine margins: implications for carbon capture and storage within the Rotliegend Group, Southern North Sea
The Southern North Sea Basins of the United Kingdom were renowned for their hydrocarbon resources and exploited extensively from the 1960s to the 1990s. The Permian Leman Sandstone in particular formed an excellent reservoir due to its extensive clean aeolian sediments and was subsequently explored for decades, resulting in a wealth of subsurface data that are now widely accessible. The strata of the Leman Sandstone comprises mixed continental deposits from aeolian, fluvial and lacustrine environments which interfinger with the saline lake deposits of the Silverpit Formation. With the potential reassessment of depleted gas reservoirs in the North Sea for use as sequestration targets for captured carbon dioxide, there is significant renewed interest in the reservoir geology of the Leman Sandstone. A regional study of the sedimentology and petrophysical properties of the Leman Sandstone and Silverpit formations within quadrants 43, 44, 48 and 49 of the Southern North Sea has been conducted. Multiple interactions between the depositional environments are observed, resulting in a complex interplay between aeolian and lacustrine transgressive/regressive events, and migration and expansion/contraction of the fluvial system. In wireline petrophysical data, each depositional environment, along with their transitional environments, form relatively distinct clusters that can be used as a predictive tool for reservoir interpretation in the absence of core, despite extensive sediment recycling between environments
Planetary Candidates Observed by Kepler. VIII. A Fully Automated Catalog with Measured Completeness and Reliability Based on Data Release 25
We present the Kepler Object of Interest (KOI) catalog of transiting exoplanets based on searching 4 yr of Kepler time series photometry (Data Release 25, Q1âQ17). The catalog contains 8054 KOIs, of which 4034 are planet candidates with periods between 0.25 and 632 days. Of these candidates, 219 are new, including two in multiplanet systems (KOI-82.06 and KOI-2926.05) and 10 high-reliability, terrestrial-size, habitable zone candidates. This catalog was created using a tool called the Robovetter, which automatically vets the DR25 threshold crossing events (TCEs). The Robovetter also vetted simulated data sets and measured how well it was able to separate TCEs caused by noise from those caused by low signal-to-noise transits. We discuss the Robovetter and the metrics it uses to sort TCEs. For orbital periods less than 100 days the Robovetter completeness (the fraction of simulated transits that are determined to be planet candidates) across all observed stars is greater than 85%. For the same period range, the catalog reliability (the fraction of candidates that are not due to instrumental or stellar noise) is greater than 98%. However, for low signal-to-noise candidates between 200 and 500 days around FGK-dwarf stars, the Robovetter is 76.7% complete and the catalog is 50.5% reliable. The KOI catalog, the transit fits, and all of the simulated data used to characterize this catalog are available at the NASA Exoplanet Archive
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