Event-related potentials and monoamines in autistic children on a clinical trial of fenfluramine

Introduction: As autistic persons have problems with selecting and encoding meaningful stimuli and multi-centre studies (Ritvo et al., 1983, 1986) had reported mild behavioural improvements following treatment with fenfluramine, event-related potential (ERP) stages of information processing were studied in childhood autism as part of a double blind crossover study of the efficacy of dl fenfluramine. . Methods: Acceptable recordings were derived from midline and 4 lateral sites on the scalp of 7 from 14 young persons with autism who understood the task (6 male, 1 female 5.8-17.7 years-of-age). A three-tone oddball paradigm was presented in a passive and active-task form (72% at 1 kHz, 14% at 0.5 kHz and 14% at 2.0 kHz) under placebo and drug conditions (where each condition lasted 5 months). Eleven patients provided blood and urine samples for monoamine analyses in both conditions. Results: a) With fenfluramine treatment blood serotonin decreased and urinary catecholamine levels fell (25-45%, but dopamine utilization (HVA/DA) increased 2-4-fold. b) Under fenfluramine autistic subjects responded non-significantly faster, with fewer errors of omission and improved /decreased beta criterion (signal detection). [IQ measures increased 7.5 points.] c) N1 amplitudes (Fz) decreased and latencies increased in the fenfluramine condition. Early negativity (especially on the right) correlated inversely with HVA/DA actvivity. Subtraction of the ERPs in nontarget from target conditions showed that the Negative difference (Nd) increased during fenfluramine treatment. d) P3 amplitudes (especially after the deviants) increased with fenfluramine treatment. But in the difference waveform (active-minus-passive condition) the P3 amplitude was halved. The distribution of the P3 component moved rostrally with treatment. Conclusions: N1 and P3 components of the ERP were responsive to fenfluramine treament. Treatment appears to have mildly improved early stimulus processing at stages represented by the early negative components, but to have mildly impaired processing at the P3-stage. The N1 / Nd - related improvement seems to be related to increased dopamine activity (cf. neuroleptic-like properties of racemate fenfluramine)

Adsorbate-induced surface stress, surface strain and surface reconstruction : S on Cu(100) and Ni(100)

Density functional theory (DFT) calculations have been applied to investigate the known difference in behaviour of S adsorption on Cu(100) and Ni(100). Both surfaces form a 0.25 ML (2 × 2) adsorption phase, but while at higher coverage a 0.5 ML c(2 × 2) phase forms on Ni(100), on Cu(100) only a reconstructed 0.47 ML (√17 × √17)R14° structure occurs. Calculations of the energy, structure, and surface stress of (2 × 2) and c(2 × 2) phases on both substrates show there is an energy advantage on both surfaces to form the higher coverage phase, but that both surfaces show local surface strain around the S atoms in the (2 × 2) phase, a phenomenon previously investigated only on Cu(100). More than forty different structural models of the Cu(100)(√17 × √17)R14°-S phase have been investigated. The pseudo-(100)c(2 × 2) structure previously proposed, containing 16 Cu adatoms per unit mesh in the reconstructed layer, is found to be less energetically favourable than many other possible structures, even after taking account of local structural relaxations. Significantly more favourable is a structure with 12 Cu adatoms per (√17 × √17)R14° unit mesh, previously proposed on the basis of scanning tunnelling microscopy (STM), and found to yield simulated STM images in good agreement with experiment. This model has all S atoms in local 4-fold coordinated hollows relative to the Cu atoms below, half being located above Cu adatoms with the remainder lying above the underlying outermost substrate layer. However, an alternative model with only 4 Cu adatoms and with half the S atoms at 3-fold coordinated sites on the periphery of the Cu adatom cluster, has an even lower energy and gives simulated STM images in excellent agreement with experiment

Asymptotic information leakage under one-try attacks

We study the asymptotic behaviour of (a) information leakage and (b) adversary’s error probability in information hiding systems modelled as noisy channels. Specifically, we assume the attacker can make a single guess after observing n independent executions of the system, throughout which the secret information is kept fixed. We show that the asymptotic behaviour of quantities (a) and (b) can be determined in a simple way from the channel matrix. Moreover, simple and tight bounds on them as functions of n show that the convergence is exponential. We also discuss feasible methods to evaluate the rate of convergence. Our results cover both the Bayesian case, where a prior probability distribution on the secrets is assumed known to the attacker, and the maximum-likelihood case, where the attacker does not know such distribution. In the Bayesian case, we identify the distributions that maximize the leakage. We consider both the min-entropy setting studied by Smith and the additive form recently proposed by Braun et al., and show the two forms do agree asymptotically. Next, we extend these results to a more sophisticated eavesdropping scenario, where the attacker can perform a (noisy) observation at each state of the computation and the systems are modelled as hidden Markov models

Sen and the art of educational maintenance: evidencing a capability, as opposed to an effectiveness, approach to schooling

There are few more widely applied terms in common parlance than ‘capability’. It is used (inaccurately) to represent everything from the aspiration to provide opportunity to notions of innate academic ability, with everything in between claiming apostolic succession to Amartya Sen, who (with apologies to Aristotle) first developed the concept. This paper attempts to warrant an adaptation of Sen’s capability theory to schooling and schooling policy, and to proof his concepts in the new setting using research involving 100 pupils from 5 English secondary schools and a schedule of questions derived from the capability literature. The findings suggest that a capability approach can provide an alternative to the dominant Benthamite school effectiveness paradigm, and can offer a sound theoretical framework for understanding better the assumed relationship between schooling and well-being

Effective theory for wall-antiwall system

We propose a useful method for deriving the effective theory for a system where BPS and anti-BPS domain walls coexist. Our method respects an approximately preserved SUSY near each wall. Due to the finite width of the walls, SUSY breaking terms arise at tree-level, which are exponentially suppressed. A practical approximation using the BPS wall solutions is also discussed. We show that a tachyonic mode appears in the matter sector if the corresponding mode function has a broader profile than the wall width.Comment: LaTeX file, 30 page, 5 eps figures, references adde

Trust in Crowds: probabilistic behaviour in anonymity protocols

The existing analysis of the Crowds anonymity protocol assumes that a participating member is either ‘honest’ or ‘corrupted’. This paper generalises this analysis so that each member is assumed to maliciously disclose the identity of other nodes with a probability determined by her vulnerability to corruption. Within this model, the trust in a principal is defined to be the probability that she behaves honestly. We investigate the effect of such a probabilistic behaviour on the anonymity of the principals participating in the protocol, and formulate the necessary conditions to achieve ‘probable innocence’. Using these conditions, we propose a generalised Crowds-Trust protocol which uses trust information to achieves ‘probable innocence’ for principals exhibiting probabilistic behaviour

Tuning into the real effect of smartphone use on parenting: A multiverse analysis

Background Concerns have been raised regarding the potential negative impacts of parents' smartphone use on the parent-child relationship. A scoping literature review indicated inconsistent effects, arguably attributable to different conceptualizations of parent phone use and conflation of phone use with technological interference. Methods Based on a sample of n = 3, 659 parents collected in partnership with a national public broadcaster, we conducted a multiverse analysis. We explored 84 different analytic choices to address whether associations were weak versus robust, and provide clearer direction for measurement, theory, and practice. Effects were assessed in relation to p values, effect sizes, and AIC; we further conducted a meta‐analytic sensitivity check. Results Direct associations between smartphone use and parenting were relatively weak and mixed. Instead, the relation between use and parenting depended on level of technological interference. This pattern was particularly robust for family displacement. At low levels of displacing time with family using technology, more smartphone use was associated with better (not worse) parenting. Conclusions Our results indicate fragility in findings of risks for parental smartphone use on parenting; there were few concerns in this regard. Rather, at low levels of technological interference, more phone use was associated with higher parenting quality. Scholars should avoid generalized narratives of family risk and seek to uncover real effects of smartphone use on family outcomes across diverse households and contexts

Jastrow-type calculations of one-nucleon removal reactions on open ss-dd shell nuclei

Single-particle overlap functions and spectroscopic factors are calculated on the basis of Jastrow-type one-body density matrices of open-shell nuclei constructed by using a factor cluster expansion. The calculations use the relationship between the overlap functions corresponding to bound states of the $(A-1)$-particle system and the one-body density matrix for the ground state of the $A$-particle system. In this work we extend our previous analyses of reactions on closed-shell nuclei by using the resulting overlap functions for the description of the cross sections of $(p,d)$ reactions on the open $s$-$d$ shell nuclei $^{24}$Mg, $^{28}$Si and $^{32}$S and of $^{32}$S$(e,e^{\prime}p)$ reaction. The relative role of both shell structure and short-range correlations incorporated in the correlation approach on the spectroscopic factors and the reaction cross sections is pointed out.Comment: 11 pages, 5 figures, to be published in Phys. Rev.

Rates and style of Cenozoic deformation around the Gonghe basin, northeastern Tibetan Plateau

The northeastern Tibetan Plateau constitutes a transitional region between the lowrelief physiographic plateau to the south and the high-relief ranges of the Qilian Shan to the north. Cenozoic deformation across this margin of the plateau is associated with localized growth of fault-cored mountain ranges and associated basins. Herein, we combine detailed structural analysis of the geometry of range-bounding faults and deformation of foreland basin strata with geomorphic and exhumational records of erosion in hangingwall ranges in order to investigate the magnitude, timing, and style of deformation along the two primary fault systems, the Qinghai Nan Shan and the Gonghe Nan Shan. Structural mapping shows that both ranges have developed above imbricate fans of listric thrust faults, which sole into décollements in the middle crust. Restoration of shortening along balanced cross sections suggests a minimum of 0.8-2.2 km and 5.1-6.9 km of shortening, respectively. Growth strata in the associated foreland basin record the onset of deformation on the two fault systems at ca. 6-10 Ma and ca. 7-10 Ma, respectively, and thus our analysis suggests late Cenozoic shortening rates of 0.2 +0.2/-0.1 km/m.y. and 0.7 +0.3/-0.2 km/m.y. along the north and south sides of Gonghe Basin. Along the Qinghai Nan Shan, these rates are similar to late Pleistocene slip rates of ~0.10 ± 0.04 mm/yr, derived from restoration and dating of a deformed alluvial-fan surface. Collectively, our results imply that deformation along both flanks of the doubly vergent Qilian Shan-Nan Shan initiated by ca. 10 Ma and that subsequent shortening has been relatively steady since that time

Tight-binding parameters for charge transfer along DNA

We systematically examine all the tight-binding parameters pertinent to charge transfer along DNA. The $\pi$ molecular structure of the four DNA bases (adenine, thymine, cytosine, and guanine) is investigated by using the linear combination of atomic orbitals method with a recently introduced parametrization. The HOMO and LUMO wavefunctions and energies of DNA bases are discussed and then used for calculating the corresponding wavefunctions of the two B-DNA base-pairs (adenine-thymine and guanine-cytosine). The obtained HOMO and LUMO energies of the bases are in good agreement with available experimental values. Our results are then used for estimating the complete set of charge transfer parameters between neighboring bases and also between successive base-pairs, considering all possible combinations between them, for both electrons and holes. The calculated microscopic quantities can be used in mesoscopic theoretical models of electron or hole transfer along the DNA double helix, as they provide the necessary parameters for a tight-binding phenomenological description based on the $\pi$ molecular overlap. We find that usually the hopping parameters for holes are higher in magnitude compared to the ones for electrons, which probably indicates that hole transport along DNA is more favorable than electron transport. Our findings are also compared with existing calculations from first principles.Comment: 15 pages, 3 figures, 7 table