Associations between Religious Fundamentalism and Attitudes towards Homosexuality: A Study into the Differences between Attitudes towards Gay Men and Lesbians as Individuals and Same Sex Relations.

It has long been reported in social research that individuals demonstrating a higher degree of religiosity lend to exhibit more negative attitudes towards homosexuality. However, there is little research in the literature that differentiates between altitudes towards gays and lesbians as individuals and the intimate acts they perform with the same sex. This research proposes to first of all confirm whether there is a relationship between religious fundamentalism and attitudes towards homosexuality, and further to decipher the potential differences in altitudes towards gays and lesbians as individuals and same-sex acts. A self-report survey was completed by 94 students at a small Midwestern college in obtaining data for this research

How Early Education and Pet Therapy May Help Nurses With Compassion Fatigue

Abstract Although there is a great deal of research on the causes of compassion fatigue, there is little research on prevention techniques or ways to combat compassion fatigue. The purpose of this qualitative phenomenological study was to discover if nurses are prepared to cope with occupational stress and compassion fatigue. A secondary purpose was to examine the perceived benefit that pet therapy can have as a possible stress reduction technique to decrease the effects of compassion fatigue. This research was conducted by gathering data via semistructured interviews. The researcher interviewed nurses who were currently practicing patient care and scored as moderate or high risk for compassion fatigue on the Professional Quality of Life Scale. The study sample consisted of six nurses. Data were analyzed using an interpretative phenomenological analysis approach. The research findings indicated that compassion fatigue elevates the level of distress nurses experience while caring for patients, affecting their ability to be servant leaders. The results also illuminated a perceived lack of education to prepare nurses for the challenges they would likely face during their career, as well as the perceived benefit of pet therapy on nurses’ ability to manage their occupational stress and possibly decrease the effects of or cope with compassion fatigue. Keywords: nurses, compassion fatigue, pet therapy, servant leader, educatio

Optoelectronic properties and energy transport processes in cylindrical J-aggregates

textThe light harvesting systems of photosynthetic organisms harness solar energy by efficient light capture and subsequent transport of the light’s energy to a chemical reaction center. Man-made optical devices could benefit by mimicking these naturally occurring light harvesting processes. Supramolecular organic nanostructures, composed of the amphiphilic carbocyanine dye 3,3’-bis- (2-sulfopropyl)-5,5’,6,6’-tetrachloro-1,1’- dioctylbenzimida-carbocyanine (C8S3), self assemble in aqueous solution to form tubular, double-walled J-aggregates. These J-aggregates have drawn comparisons to light harvesting systems, owing to their optical and structural similarities to the cylindrical chlorosomes (antenna) from green sulfur bacteria. This research utilizes optical spectroscopy and microscopy to study the supramolecular origins of the exciton transitions and fundamental nature of exciton energy transport in C8S3 artificial light harvesting systems. Two J-aggregate morphologies are investigated: well-separated, double-walled nanotubes and bundles of agglomerated nanotubes. Linear dichroism spectroscopy of flow-aligned nanotubes is used to generate the first quantitative, polarized model for the complicated C8S3 nanotube excitonic absorption spectrum that is consistent with theoretical predictions. The C8S3 J-aggregate photophysical properties are further explored, as the Stokes shift, quantum yield, and spectral line broadening are measured as a function of temperature from 77 – 298 K. The temperature-dependent emission ratios of the C8S3 J-aggregate two-band fluorescence spectra reveal that nanotube emission is well described with Boltzmann partitioning between states, while the bundles’ is not. Finally, understanding energy transport in these materials is critical for the proposed use of artificial light harvesting systems in optoelectronic devices. The spatial extent of energy transfer in individual C8S3 J- aggregate structures is directly determined using fluorescence imaging. We find that aggregate structural hierarchy greatly influences exciton transport distances: impressive average exciton migration distances of ~ 150 nm are measured along the nanotubes, while these distances increase to over 500 nm in the bundle superstructures.Chemistr

Estimating Under Five Mortality in Space and Time in a Developing World Context

Accurate estimates of the under-5 mortality rate (U5MR) in a developing world context are a key barometer of the health of a nation. This paper describes new models to analyze survey data on mortality in this context. We are interested in both spatial and temporal description, that is, wishing to estimate U5MR across regions and years, and to investigate the association between the U5MR and spatially-varying covariate surfaces. We illustrate the methodology by producing yearly estimates for subnational areas in Kenya over the period 1980 - 2014 using data from demographic health surveys (DHS). We use a binomial likelihood with fixed effects for the urban/rural stratification to account for the complex survey design. We carry out smoothing using Bayesian hierarchical models with continuous spatial and temporally discrete components. A key component of the model is an offset to adjust for bias due to the effects of HIV epidemics. Substantively, there has been a sharp decline in U5MR in the period 1980 - 2014, but large variability in estimated subnational rates remains. A priority for future research is understanding this variability. Temperature, precipitation and a measure of malaria infection prevalence were candidates for inclusion in the covariate model.Comment: 36 pages, 11 figure

THE COVID-19 DOMINO EFFECT: How the pandemic deepened systemic oppression for Black and Latino Illinoisans

COVID-19 and the resulting instability has left an indelible mark on every corner of our society. The compounding stressors of uncertain futures, health crises, isolation, financial strain, individual and collective trauma, and juggling life responsibilities is taking a massive toll on people. While the virus itself does not discriminate, the systems in place and the responses do: Black and Latino people are bearing the brunt of the negative impacts.The following data and stories illustrate how the pandemic started a domino effect for Black and Latino Illinoisans. When you are already living on the edge, losing one support can cause others to crumble. Just as the ripple effects of the pandemic did not affect us equally, the recovery must not take a one-size-fits-all approach. We must invest in the hardest hit communities—and that means providing a foundation for people of color to heal and thrive

A bitter pill to swallow: Registered nurses and medicines regulation in remote Australia

INTRODUCTION: Access to essential medicines is a human right and an objective of the National Medicines Policy in Australia. Health workforce distribution characteristics in remote Australia implies registered nurses (RNs) may find themselves responsible for a broader range of activities in the medication management cycle than they would be elsewhere in the nation. The regulation of health professionals and their training requirements provides essential but complex protections for the public. These protections include the National Registration and Accreditation Scheme for health practitioners and the Australian Health Practitioner Regulation Agency. Other levels of control or regulation are also exerted over health professionals via mechanisms such as salaries and funding arrangements, insurance requirements, admitting rights to healthcare facilities, and legislation controlling the use of medicines and therapeutic devices. This study aimed to examine national legislation and regulations concerning the use of medications from a nursing perspective, focusing on the context of health service delivery in remote areas. METHODS: Australian state and territory medicines legislation and regulations was interrogated for answers to the questions \u27Can an RN prescribe a medication?\u27, \u27Can an RN dispense a medication?\u27, \u27Can an RN supply or issue a medication?\u27 and \u27Can an RN administer a medication?\u27 RESULTS: Inconsistencies were identified nationally in the names and general structure of the legislation, the location of information relating to authorised roles with regards to medications and key terms used to describe medicines and the elements of the medication management cycle. Administrations of Schedule 4 and 8 medicine according to an order from an authorised prescriber are the only nationally consistent roles RNs are authorised to undertake with regards to medicines. Twenty-eight variations were identified with regards to additional authorisations for RNs. CONCLUSION: RNs make up more than half of the registered Australian health professional workforce and are the most consistently distributed across the nation, yet their legislated responsibilities in relation to working with medicines are inconsistent. Given the inconsistencies, RNs providing health care in remote Australia may be unable to undertake aspects of the medication management cycle that their work environment demands in the best interest of their patients and absence of other healthcare providers. The lack of legislative consistency nationally for medicines in Australia is likely to impede timely access to medications for patients. Regulatory inconsistencies may also result in RNs working well below or beyond their legal scope of practice, thereby creating clinical and workforce risks. Such risks are a significant matter for remote health service provision. Resolving these issues will require a collaborative national approach with consideration given to how the health workforce is distributed, current nursing responsibilities and relevant service delivery models for remote Australia

A bitter pill to swallow: registered nurses and medicines regulation in remote Australia

Introduction: Access to essential medicines is a human right and an objective of the National Medicines Policy in Australia. Health workforce distribution characteristics in remote Australia implies registered nurses (RNs) may find themselves responsible for a broader range of activities in the medication management cycle than they would be elsewhere in the nation. The regulation of health professionals and their training requirements provides essential but complex protections for the public. These protections include the National Registration and Accreditation Scheme for health practitioners and the Australian Health Practitioner Regulation Agency. Other levels of control or regulation are also exerted over health professionals via mechanisms such as salaries and funding arrangements, insurance requirements, admitting rights to healthcare facilities, and legislation controlling the use of medicines and therapeutic devices. This study aimed to examine national legislation and regulations concerning the use of medications from a nursing perspective, focusing on the context of health service delivery in remote areas. Methods: Australian state and territory medicines legislation and regulations was interrogated for answers to the questions 'Can an RN prescribe a medication?', 'Can an RN dispense a medication?', 'Can an RN supply or issue a medication?' and 'Can an RN administer a medication?' Results: Inconsistencies were identified nationally in the names and general structure of the legislation, the location of information relating to authorised roles with regards to medications and key terms used to describe medicines and the elements of the medication management cycle. Administrations of Schedule 4 and 8 medicine according to an order from an authorised prescriber are the only nationally consistent roles RNs are authorised to undertake with regards to medicines. Twenty-eight variations were identified with regards to additional authorisations for RNs. Conclusion: RNs make up more than half of the registered Australian health professional workforce and are the most consistently distributed across the nation, yet their legislated responsibilities in relation to working with medicines are inconsistent. Given the inconsistencies, RNs providing health care in remote Australia may be unable to undertake aspects of the medication management cycle that their work environment demands in the best interest of their patients and absence of other healthcare providers. The lack of legislative consistency nationally for medicines in Australia is likely to impede timely access to medications for patients. Regulatory inconsistencies may also result in RNs working well below or beyond their legal scope of practice, thereby creating clinical and workforce risks. Such risks are a significant matter for remote health service provision. Resolving these issues will require a collaborative national approach with consideration given to how the health workforce is distributed, current nursing responsibilities and relevant service delivery models for remote Australia

PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex

The levels of cAMP are regulated by phosphodiesterase enzymes (PDEs), which are targets for the treatment of inflammatory disorders. We have previously shown that PDE8 regulates T cell motility. Here, for the first time, we report that PDE8A exerts part of its control of T cell function through the V-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) kinase signaling pathway. To examine T cell motility under physiologic conditions, we analyzed T cell interactions with endothelial cells and ligands in flow assays. The highly PDE8-selective enzymatic inhibitor PF-04957325 suppresses adhesion of in vivo myelin oligodendrocyte glycoprotein (MOG) activated inflammatory CD4(+) T effector (Teff) cells to brain endothelial cells under shear stress. Recently, PDE8A was shown to associate with Raf-1 creating a compartment of low cAMP levels around Raf-1 thereby protecting it from protein kinase A (PKA) mediated inhibitory phosphorylation. To test the function of this complex in Teff cells, we used a cell permeable peptide that selectively disrupts the PDE8A-Raf-1 interaction. The disruptor peptide inhibits the Teff-endothelial cell interaction more potently than the enzymatic inhibitor. Furthermore, the LFA-1/ICAM-1 interaction was identified as a target of disruptor peptide mediated reduction of adhesion, spreading and locomotion of Teff cells under flow. Mechanistically, we observed that disruption of the PDE8A-Raf-1 complex profoundly alters Raf-1 signaling in Teff cells. Collectively, our studies demonstrate that PDE8A inhibition by enzymatic inhibitors or PDE8A-Raf-1 kinase complex disruptors decreases Teff cell adhesion and migration under flow, and represents a novel approach to target T cells in inflammation