5 research outputs found
Treatment of human acute schistosomiasis with oxamniquine induces an increase in interferon-γ response to Schistosoma mansoni antigens
Patients with acute schistosomiasis were studied before and after
oxamniquine treatment. They had been exposed to cercariae 5 to 9 weeks
before, and presented compatible clinical manifestations, eosinophilia,
and high levels of total IgE. Interferon-g (IFN-γ) and
interleukin-4 were measured by ELISA in whole blood samples under
soluble egg antigen or soluble adult worm preparation stimulation.
After treatment, the reduction of leukocytosis and eosinophilia were
not significant, but total IgE levels decreased significantly, in
contrast to IFN-γ levels that were significantly increased. The
oxamniquine treatment of acute schistosomiasis patients is followed by
an improvement of a Th1 response in vitro. If this response has a
protective aspect is unknown, and some investigations need to be
realized
Preliminary results on the effects of CD40/CD40L interactions and SAC-induction on IFN-gamma expression in human schistosomiasis
In this communication the authors analyzed the pattern of expression of IFN-gamma as a surrogate type 1 response in different clinical forms of schistosomiasis in response to stimulation involving T-cell dependent and T-cell independent pathways, to investigate which pathways were functional in human schistosomiasis, and to further characterize the nature of Th1 response impairment in this parasitic disease