Deciphering the role of Epstein-Barr virus in the pathogenesis of T and NK cell lymphoproliferations

Epstein-Barr virus (EBV) is a highly successful herpesvirus, colonizing more than 90% of the adult human population worldwide, although it is also associated with various malignant diseases. Primary infection is usually clinically silent, and subsequent establishment of latency in the memory B lymphocyte compartment allows persistence of the virus in the infected host for life. EBV is so markedly B-lymphotropic when exposed to human lymphocytes in vitro that the association of EBV with rare but distinct types of T and NK cell lymphoproliferations was quite unexpected. Whilst relatively rare, these EBV-associated T and NK lymphoproliferations can be therapeutically challenging and prognosis for the majority of patients is dismal. In this review, we summarize the current knowledge on the role of EBV in the pathogenesis of these tumours, and the implications for treatment. \ud \u

Fan Letters to the Cultural Industries: Border Literature about Mass Media

The concentration of the Mexican and U.S. cultural industries in cities outside of the border region and the intermittent outsourcing of Hollywood movies to production facilities in Baja, California, have had a marked impact on the literary practice of fronterizo \u27border\u27 intellectuals. This essay discusses the theme of the cinema in three narratives by authors from the U.S.-Mexico border region: Hotel Frontera ( Border Hotel ), by Gabriel Trujillo Muñoz, Canícula, by Norma Elia Cantú, and The Magic of Blood, by Dagoberto Gilb. These narratives provide ethnographic information about the reception of nationally distributed mass media in the border region; at the same time they produce a contestatory discourse that challenges the manner in which the border and its populations have been portrayed and employed in the U.S. and Mexican film industries. The study of film culture must take into consideration patterns of consumption as well as production, and literature about mass media is one arena through which it is possible to focus on both of these processes simultaneously. Fronteriza/o writing about cinema reveals a desire to inhabit popular cinematic genres such as film noir and the western while at the same time retaining a critical stance towards them. This ambivalence is understood as a localist response to the marginalization of fronteriza/o cultural production in a bi-national context, rather than as general suspicion toward visual mass media on the part of traditional literary intellectuals

The development of a humor styles questionnaire for younger children

Despite the adaptation of the humor styles questionnaire for older children a measure suitable for children below the age of eleven was needed. The current research involved three separate studies leading to the creation of the humor styles questionnaire for younger children (HSQ-Y), suitable for those aged 8–11 years. Study one involved the development of a measure to assess aggressive and affiliative humor. Subsequently, study two involved the adaptation of the measure to include all four humor styles, which was administered to children alongside a measure of friendship quality. To provide further validation for the HSQ-Y as a measure, study three involved the administration of the HSQ-Y twice over a three-week period and peer reports of the four humor styles. Several measures of psychosocial adjustment were also included. The HSQ-Y was found to be a reliable and valid measure of the four humor styles in children aged 8–11 years. Associations between the humor styles and psychosocial adjustment variables were also found, supporting the discriminant validity of the measure

Letter to Jack Bissett regarding donation by SEAALL, June 16, 2006

A letter from Claire Germain and Susan Fox thanking Jack Bissett and SEAALL for a donation to the AALL Scholarship Fund and the Centennial Fund

Letter to Jack Bissett regarding donation by SEAALL, June 2, 2006

A letter from Claire Germain and Susan Fox thanking Jack Bissett and SEAALL for a donation to the AALL & West/George A. Strait Minority Scholarship Endowment

The non-receptor tyrosine kinase ACK: regulatory mechanisms, signalling pathways and opportunities for attACKing cancer

Activated Cdc42-associated kinase or ACK, is a non-receptor tyrosine kinase and an effector protein for the small G protein Cdc42. A substantial body of evidence has accumulated in the past few years heavily implicating ACK as a driver of oncogenic processes. Concomitantly, more is also being revealed regarding the signalling pathways involving ACK and molecular details of its modes of action. Some details are also available regarding the regulatory mechanisms of this kinase, including activation and regulation of its catalytic activity, however a full understanding of these aspects remains elusive. This review considers the current knowledge base concerning ACK and summarises efforts and future prospects to target ACK therapeutically in cancer.MR

Preliminary steps towards a more preventative approach to eliminating violence against women in Europe

This article discusses findings from a project funded by the European Commission’s DAPHNE III programme that sought to enhance the provision of relationship education and domestic abuse prevention in European schools and other educational facilities: the REaDAPt (Relationship Education and Domestic Abuse Prevention tuition) project. It summarizes what is known about effective prevention from the research literature before explaining what the REaDAPt project revealed about changing attitudes, about implementing and evaluating domestic abuse prevention programmes in educational settings, and about being responsive to young people’s perspectives in the delivery of interventions. The article concludes by highlighting the iterative nature of the research needed to help develop relationship education and domestic abuse prevention tuition on a Europe-wide scale. </jats:p

Labelled as ‘risky’ in an era of control: how young people experience and respond to the stigma of criminalised identities.

The construction and labelling of groups of young people as ‘risky’ triggers a multifaceted and dynamic social process of stigma that frequently results in reduced life chances and limited opportunities for self-development. Drawing on case-study data from four European countries, this article focuses on the ways in which stigma is reproduced through interactions and interventions that label young people. Our analysis explores how young people experience and understand stigma, and how they respond to it. Framed within a theoretical understanding of stigma as a form of power, we examine its components and cyclical process, its role in shaping policies of social control, and its consequences for groups of ‘risky’ young people. Our analysis builds upon and develops Link and Phelan’s (2001) reconceptualization of stigma to include reference to young people’s reactions and responses: alienation and marginalization; anger and resistance; empathy and generativity. We argue that stigma acts primarily as an inhibitor of young people’s engagement in wider society, serving to further reduce access to beneficial opportunities. However, some young people are able to resist the label, and, for them, resistance can become generative and enabling.info:eu-repo/semantics/publishedVersio

Humour styles as moderators and mediators of the relationship between peer-victimisation and internalising

Peer-victimisation is associated with numerous, negative psycho-social outcomes and meta-analyses indicate that internalising difficulties are particularly salient. Given the inherently social nature of humour, and previous work supporting the association of humour with wellbeing, we investigated whether specific humour styles mediated or moderated the relationship between peer-victimisation and depressive symptomatology. Peer-reports of physical, verbal, and indirect peer-victimisation were collected for 1,241 English adolescents aged 11-13 years old. Self-reports of humour style and depression were also collected. Analyses using Structural Equation Modeling revealed no moderation by humour was evident. Verbal victimisation had the largest association with depressive symptomatology and a positive association between verbal victimisation combined with large, positive association between self-defeating humour and depressive symptomatology provides evidence for an indirect pathways via self-defeating humour use. The implications of these results for our understanding of peer-victimisation, adjustment, and humour are considered