Epidemiological aspects of postoperativelumbar incisional hernias

Department of Urology and Surgical Nephrology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 8th International Medical Congress for Students and Young Doctors, September 24-26, 2020Introduction. Incisional lumbar hernia is a complication of 17.1% of the surgery on the kidneys and ureter and constitutes 8% of the total hernias of the antero-lateral abdominal wall. Aim of the study. Evaluation of incidence of lumbar incisional hernias following urological surgery and establishment of epidemiological data for a period of 1 year. Materials and methods.. The study developed 32 care patients who underwent surgery on the kidneys with dynamic surveillance up to 12 months. In the case of studies or evaluation of indices such as serum glycemia, the diagnosis of obesity has been established, through the use (BMI) and anthropometric indices of patients. Results. Results. The study shows that in 94% of patients the risk of developing postoperative hernias is increased in the first year after the surgery, considering a significant exceedance of BMI standards, positive uroculture, the presence of diabetes or high blood sugar levels. Thus, the study shows that the lombotomy failure rate represents 11% of the cases. Conclusions. The incidence of incisional hernias at 6 months was 10%, at 12 months the incidence of 18%. The postoperative evolution of patients at increased risk of herniation is uncertain and depends on the presence of risk factors such as diabetes, obesity, anthropometric indices. Diabetes has a significant value in the diagnosis and prophylaxis of incisional hernias

Factorii determinanţi ai fluxurilor străine directe de investiţii în Uniunea Europeană

Attracting of foreign direct investments (FDI) has becoming increasingly researched worldwide as they contribute to the economic growth of countries. The most important factors determining the choice of firms to expand internationally through FDI are: access to local resources, access to the domestic market, a high level of efficiency and strategic asset acquisition. The FDI flows of the European Union are still influenced by the global economic and financial crisis. In 2012 the FDI outflows decreased with 53 % as compared to 2011, registering their lowest level since 2004. The recovery will take longer than expected, mostly because of global economic fragility and policy uncertainty

THE PARTICULARITIES OF THE CLARIFICATION PROCESS WITH BENTONITE OF WHITE WINE VINEGAR

In this study, the physicochemical properties of Italian and German bentonites were evaluated, including the physicochemical characteristics of white wine vinegar. Once established, the optimal clarification regime and its physical parameters were determined. After establishing the optimized sedimentation parameters, the influence of different doses of bentonite on the physicochemical and organoleptic characteristics of the analyzed vinegar was investigated. With this was determined the influence of the different contact periods of vinegar with bentonite, on the physicochemical parameters of clarified wine vinegar. Thus, for the Italian bentonite, the optimal conditions for the clarification process were: dose of bentonite — 2.03 g · 25L-1, time — 45 min, temperature — 20 ± 1 °C, stirring time — 60 s, centrifugation time — 3 min and spin speed of 300 min-1. Moreover, when using the German bentonite, the optimal parameters were: bentonite dose — 1.96 g · L-1, contact time — 45 min, temperature — 20 ± 1 °C, stirring time — 300 s, centrifugation time — 3 min and spin speed of 300 min-1. Finally, the sensory analysis of wine vinegar was performed and it was established, from the data, which of the analyzed bentonites has properties that are more efficient on the clarification process.In this study, the physicochemical properties of Italian and German bentonites were evaluated, including the physicochemical characteristics of white wine vinegar. Once established, the optimal clarification regime and its physical parameters were determined. After establishing the optimized sedimentation parameters, the influence of different doses of bentonite on the physicochemical and organoleptic characteristics of the analyzed vinegar was investigated. With this was determined the influence of the different contact periods of vinegar with bentonite, on the physicochemical parameters of clarified wine vinegar. Thus, for the Italian bentonite, the optimal conditions for the clarification process were: dose of bentonite — 2.03 g · 25L-1, time — 45 min, temperature — 20 ± 1 °C, stirring time — 60 s, centrifugation time — 3 min and spin speed of 300 min-1. Moreover, when using the German bentonite, the optimal parameters were: bentonite dose — 1.96 g · L-1, contact time — 45 min, temperature — 20 ± 1 °C, stirring time — 300 s, centrifugation time — 3 min and spin speed of 300 min-1. Finally, the sensory analysis of wine vinegar was performed and it was established, from the data, which of the analyzed bentonites has properties that are more efficient on the clarification process

Manifestări gastrointestinale și hepatice în infecția COVID 19

Background. SARS-CoV-2 represents an infection which affects the respiratory system, but which also shares gastrointestinal symptoms too. Objective of the study. The evaluation of the incidence and prevalence of gastrointestinal manifestations caused by SARS-CoV-2 virus infection. Material and Methods. The study analyzed articles taken from PubMed platform, published in the period of 2020-2022. The search was performed using the following keywords: SARS-CoV-2, gastrointestinal, hepatic, manifestations, prevalence. In total, 99 articles were found, of which 17 met the inclusion criteria (articles in English, full text, meta-analyzes, literature reviews, original articles). Results. Cytokine-induced inflammation, intestinal dysbiosis, and vascular disorders are some of the mechanisms by which the intestinal mucosa is affected by SARS-CoV-2 virus. Covid 19 infection causes a cytokine-induced inflammatory response in the intestinal mucosa, characterized by increased levels of calprotectin. Covid infection causes intestinal dysbiosis, causing damage ot enterocytes which is resulting in diarrhea. When the SARS-CoV-2 virus replicates, it affects the hepatocyte through the mechanism of cytotoxicity, hypoxia or ischemic disorders, immune-mediated inflammatory response, and induced liver damage. The most common gastrointestinal symptoms are diarrhea (up to 34%), followed by nausea and vomiting (10%) and cytolytic syndrome (AST increase) is 58%. Conclusion. The SARS-CoV-2 virus has a direct action on the enterocyte, causing diarrhea in one third of patients. More than half of the patients infected with SARS-CoV-2 show an increase AST level explained by both the direct and indirect mechanism.Introducere. SARS-CoV-2 reprezintă o infecție cu afectare sistemului respirator, dar care manifestă și simptome gastrointestinale. Scopul lucrării. Evaluarea incidenței și prevalenței manifestărilor gastrointestinale provocate de infecția cu virusul SARS-CoV-2. Materiale și metode. În studiu au fost analizate articole preluate de pe platforma PubMed, realizate în perioada 2020-2022. Căutarea a fost efectuată utilizând cuvinte cheie: SARS-CoV-2, Gastrointestinal, hepatic, manifestations, prevalence. În total au fost găsite 99 articole dintre care 17 au corespuns criteriilor de includere (articole în limba engleză, text complet, metaanalize, sinteze ale literaturii, articole originale). Rezultate. Inflamația citokin-indusă, disbioza intestinală și dereglări vasculare sunt unele din mecanisme de afectare a mucoasei intestinale de către virusul SARS-CoV-2. Infecția Covid 19 provoacă în mucoasa intestinală un răspuns inflamator citokin-indus, caracterizat prin creșterea nivelului de calprotectina. Infecția Covid cauzează disbioza intestinală, provocând afectarea enterocitelor cu dezvoltarea diareii. Virusul SARS-CoV-2 replicându-se, afectează hepatocitul prin mecanism de citotoxicitate, hipoxie sau alterări ischemice, răspuns inflamator mediat imun, afectarea hepatică drug indusă. Cele mai comune simptome gastrointestinale sunt diareea (până la 34%), urmată de grețuri și vomă (10%) , iar sindrom citolitic (creștere ASAT) se atestă la 58%. Concluzie. Virusul SAR-CoV-2 are o acțiune directă asupra enterocitului provocând la o treime din pacienți sindrom diareic. Mai mult de jumătate din pacienții infectați cu SAR-CoV-2 prezintă creșterea nivelului ASAT explicată prin mecanisme atât directe cât și indirect

High serum unconjugated bilirubin levels in a patient with mutations in the UGT1A1 gene – clinical case presentation

Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of MoldovaBackground. The UGT1A1 gene plays a significant role in the glucuronidation of bilirubin, and the mutations of this gene lead to limitations in the synthesis of the glucuronyltransferase enzyme, which contributes to the increase in free serum bilirubin. This clinical condition is called Gilbert's syndrome. The patient with Gilbert syndrome has no clinical manifestations until the second decade of life. Scientific studies demonstrate that free serum bilirubin in patients with Gilbert syndrome is almost entirely unconjugated. We present the case study of a 17-year-old patient with Gilbert's syndrome, confirmed by molecular genetics tests

Comparative evaluation of basic characteristics in angina pectoris in elderly patients

Catedra Economie, management şi psihopedagogie în medicină, USMF Nicolae TestemiţanuCardiovascular diseases are the number one of death globally: more people die annually from cardiovascular diseases than from any other cause. According to statistics of World Health Organization cardiovascular diseases cause more than 17,3 million deaths annually worldwide, of which 7,2 million deaths from ischemic heart diseases,than manifested by angina pectoris. Bolile cardiovasculare sunt principala cauză de deces la nivel mondial. Conform datelor statistice ale Organizaţiei Mondiale a Sănătăţii patologiile cardiovasculare povoacă anual peste 17,3 milioane de decese în lume, dintre care 7,2 milione decese în urma cardiopatiei ischemice, ce se manifesta prin angor pectoral

GASTROINTESTINAL AND HEPATIC MANIFESTATIONS OF COVID 19

Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. SARS-CoV-2 reprezintă o infecție cu afectare sistemului respirator, dar care manifestă și simptome gastrointestinale. Scopul lucrării. Evaluarea incidenței și prevalenței manifestărilor gastrointestinale provocate de infecția cu virusul SARS-CoV-2. Materiale și metode. În studiu au fost analizate articole preluate de pe platforma PubMed, realizate în perioada 2020-2022. Căutarea a fost efectuată utilizând cuvinte cheie: SARS-CoV-2, Gastrointestinal, hepatic, manifestations, prevalence. În total au fost găsite 99 articole dintre care 17 au corespuns criteriilor de includere (articole în limba engleză, text complet, metaanalize, sinteze ale literaturii, articole originale). Rezultate. Inflamația citokin-indusă, disbioza intestinală și dereglări vasculare sunt unele din mecanisme de afectare a mucoasei intestinale de către virusul SARS-CoV-2. Infecția Covid 19 provoacă în mucoasa intestinală un răspuns inflamator citokin-indus, caracterizat prin creșterea nivelului de calprotectina. Infecția Covid cauzează disbioza intestinală, provocând afectarea enterocitelor cu dezvoltarea diareii. Virusul SARS-CoV-2 replicându-se, afectează hepatocitul prin mecanism de citotoxicitate, hipoxie sau alterări ischemice, răspuns inflamator mediat imun, afectarea hepatică drug indusă. Cele mai comune simptome gastrointestinale sunt diareea (până la 34%), urmată de grețuri și vomă (10%) , iar sindrom citolitic (creștere ASAT) se atestă la 58%. Concluzie. Virusul SAR-CoV-2 are o acțiune directă asupra enterocitului provocând la o treime din pacienți sindrom diareic. Mai mult de jumătate din pacienții infectați cu SAR-CoV-2 prezintă creșterea nivelului ASAT explicată prin mecanisme atât directe cât și indirecte.Background. SARS-CoV-2 represents an infection which affects the respiratory system, but which also shares gastrointestinal symptoms too. Objective of the study. The evaluation of the incidence and prevalence of gastrointestinal manifestations caused by SARS-CoV-2 virus infection. Material and Methods. The study analyzed articles taken from PubMed platform, published in the period of 2020-2022. The search was performed using the following keywords: SARS-CoV-2, gastrointestinal, hepatic, manifestations, prevalence. In total, 99 articles were found, of which 17 met the inclusion criteria (articles in English, full text, meta-analyzes, literature reviews, original articles). Results. Cytokine-induced inflammation, intestinal dysbiosis, and vascular disorders are some of the mechanisms by which the intestinal mucosa is affected by SARS-CoV-2 virus. Covid 19 infection causes a cytokine-induced inflammatory response in the intestinal mucosa, characterized by increased levels of calprotectin. Covid infection causes intestinal dysbiosis, causing damage ot enterocytes which is resulting in diarrhea. When the SARS-CoV-2 virus replicates, it affects the hepatocyte through the mechanism of cytotoxicity, hypoxia or ischemic disorders, immune-mediated inflammatory response, and induced liver damage. The most common gastrointestinal symptoms are diarrhea (up to 34%), followed by nausea and vomiting (10%) and cytolytic syndrome (AST increase) is 58%. Conclusion. The SARS-CoV-2 virus has a direct action on the enterocyte, causing diarrhea in one third of patients. More than half of the patients infected with SARS-CoV-2 show an increase AST level explained by both the direct and indirect mechanism

Factorii determinanţi ai fluxurilor străine directe de investiţii în Uniunea Europeană

Attracting of foreign direct investments (FDI) has becoming increasingly researched worldwide as they contribute to the economic growth of countries. The most important factors determining the choice of firms to expand internationally through FDI are: access to local resources, access to the domestic market, a high level of efficiency and strategic asset acquisition. The FDI flows of the European Union are still influenced by the global economic and financial crisis. In 2012 the FDI outflows decreased with 53 % as compared to 2011, registering their lowest level since 2004. The recovery will take longer than expected, mostly because of global economic fragility and policy uncertainty