Sleep patterns and creativity in children and adolescents with and without high functioning autism (HFA): a descriptive study and an intervention trial

Sleeplessness is common in childhood especially in some clinical groups and it has negative effects on child and family functioning. There is limited data suggesting a link between lack of sleep and impaired creativity and more studies are needed especially with children with autism for whom creativity is compromised and risk of sleeplessness is high. The adverse affects on children's neurobehavioral functioning caused by insufficient sleep might be reversed by removal of the sleep disturbance as a means of improving overall function of the child. The treatment of choice for childhood sleeplessness problems are behavioural approaches however they have not been sufficiently evaluated with school age typically developing children (TC) or with children with high functioning autism (HFA) and further, parents often have limited access to such treatments. Therefore this study aimed to explore the relationship between sleep and neurobehavioral functioning and creativity of children (with and without HFA) and maternal mental health by means of a descriptive study (n=65) and to evaluate the efficacy of booklet behavioural intervention for sleeplessness problems, via a multiple baseline design (n=9), and its indirect effects on children's creativity. Sleep was assessed by parent and child sleep reports as well as by actigraphy. Children's creativity was measured using the Torrance Test of Creative Thinking and newly developed tests of creativity. Measures of child neurobehavioral functioning and parental mental health were also employed. The results suggested that sleeplessness was associated with impaired child neurobehavioral functioning and maternal mental health and with reduced creativity in TC only. The booklet-based behavioural intervention appeared to be effective for the treatment of sleeplessness in TC although no associated changes in creativity were consistently found. The booklet was less useful for children with HFA. The thesis argues that sleeplessness impairs high level cognitive ability in children and affects maternal mental health. The results are clinically useful as they support the use of booklet-based behavioural interventions for sleeplessness in school age TC. The efficacy of such approach with children with HFA needs to be further explored. Nocturnal mental over-activity appeared responsible for the maintenance of sleeplessness in TC and HFA. This has important clinical implications when considering appropriate intervention approaches for this age group

Primary small cell neuroendocrine carcinoma of the breast: The histogenetic diatribe

LETTER TO EDITO

A variation of Broyden Class methods using Householder adaptive transforms

In this work we introduce and study novel Quasi Newton minimization methods based on a Hessian approximation Broyden Class-\textit{type} updating scheme, where a suitable matrix $\tilde{B}_k$ is updated instead of the current Hessian approximation $B_k$. We identify conditions which imply the convergence of the algorithm and, if exact line search is chosen, its quadratic termination. By a remarkable connection between the projection operation and Krylov spaces, such conditions can be ensured using low complexity matrices $\tilde{B}_k$ obtained projecting $B_k$ onto algebras of matrices diagonalized by products of two or three Householder matrices adaptively chosen step by step. Extended experimental tests show that the introduction of the adaptive criterion, which theoretically guarantees the convergence, considerably improves the robustness of the minimization schemes when compared with a non-adaptive choice; moreover, they show that the proposed methods could be particularly suitable to solve large scale problems where $L$-$BFGS$ performs poorly

Effect of PPARγ Inhibition during Pregnancy on Posterior Cerebral Artery Function and Structure

Peroxisome proliferator-activated receptor-γ (PPARγ), a ligand-activated transcription factor, has protective roles in the cerebral circulation and is highly activated during pregnancy. Thus, we hypothesized that PPARγ is involved in the adaptation of cerebral vasculature to pregnancy. Non-pregnant (NP) and late-pregnant (LP) rats were treated with a specific PPARγ inhibitor GW9662 (10 ]mg/kg/day, in food) or vehicle for 10 days and vascular function and structural remodeling were determined in isolated and pressurized posterior cerebral arteries (PCA). Expression of PPARγ and angiotensin type 1 receptor (AT1R) in cerebral (pial) vessels was determined by real-time RT-PCR. PPARγ inhibition decreased blood pressure and increased blood glucose in NP rats, but not in LP rats. PPARγ inhibition reduced dilation to acetylcholine and sodium nitroprusside in PCA from NP (p < 0.05 vs. LP-GW), but not LP rats. PPARγ inhibition tended to increase basal tone and myogenic activity in PCA from NP rats, but not LP rats. Structurally, PPARγ inhibition increased wall thickness in PCA from both NP and LP rats (p < 0.05), but increased distensibility only in PCA from NP rats. Pregnancy decreased expression of PPARγ and AT1R (p < 0.05) in cerebral arteries that was not affected by GW9662 treatment. These results suggest that PPARγ inhibition had significant effects on the function and structure of PCA in the NP state, but appeared to have less influence during pregnancy. Down-regulation of PPARγ and AT1R in cerebral arteries may be responsible for the lack of effect of PPARγ in cerebral vasculature and may be part of the vascular adaptation to pregnancy

Projective Bundle Adjustment from Arbitrary Initialization Using the Variable Projection Method

Bundle adjustment is used in structure-from-motion pipelines as final refinement stage requiring a sufficiently good initialization to reach a useful local mininum. Starting from an arbitrary initialization almost always gets trapped in a poor minimum. In this work we aim to obtain an initialization-free approach which returns global minima from a large proportion of purely random starting points. Our key inspiration lies in the success of the Variable Projection (VarPro) method for affine factorization problems, which have close to 100% chance of reaching a global minimum from random initialization. We find empirically that this desirable behaviour does not directly carry over to the projective case, and we consequently design and evaluate strategies to overcome this limitation. Also, by unifying the affine and the projective camera settings, we obtain numerically better conditioned reformulations of original bundle adjustment algorithms

Projective Bundle Adjustment from Arbitrary Initialization Using the Variable Projection Method

Bundle adjustment is used in structure-from-motion pipelines as final refinement stage requiring a sufficiently good initialization to reach a useful local mininum. Starting from an arbitrary initialization almost always gets trapped in a poor minimum. In this work we aim to obtain an initialization-free approach which returns global minima from a large proportion of purely random starting points. Our key inspiration lies in the success of the Variable Projection (VarPro) method for affine factorization problems, which have close to 100% chance of reaching a global minimum from random initialization. We find empirically that this desirable behaviour does not directly carry over to the projective case, and we consequently design and evaluate strategies to overcome this limitation. Also, by unifying the affine and the projective camera settings, we obtain numerically better conditioned reformulations of original bundle adjustment algorithms

Hashimoto ThYroiditis Coexistent with Papillary Thyroid Carcinoma

Several studies report a higher rate of papillary thyroid carcinomas (PTC) in patients with Hashimoto thyroiditis (HT), indicating a possible correlation between the two diseases. We studied a group of 89 subjects undergoing surgery for thyroid carcinomas compared with a control group of 89 subjects operated on for normofunctioning goiter, and a second group of 47 patients undergoing total thyroidectomy for HT. Association with HT was found in 19 of the 71 PTC subjects (26.7%) and in 8 goiter patients (8.9%), which was a significant difference (P < 0.02). Thirteen of the HT patients, mostly with the nodular form, showed coexistent PTC (27.6%). HT and PTC coexisted in several morphological, immunohistochemical, and biomolecular aspects; increased incidence of PTC in HT patients might therefore indicate that HT is a precursor of thyroid cancer. Further studies are required, however, in order to confirm this hypothesis; until then, HT patients should undergo careful clinical and technical follow-up

Metastatic seeding of colon adenocarcinoma manifesting as synchronous breast and chest wall localization: report of a case.

Colon carcinoma rarely metastasizes to the breast and it is usually associated with a poor prognosis. Even rarer is metastatic seeding of colon cancer cells in an intramammary location after surgery. Including a primary breast malignancy in the differential diagnosis of such cases is mandatory. We report a rare case of double seeding implantation of colon adenocarcinoma inside the breast parenchyma and intercostal muscles 6 years after resection of a pulmonary metastasis from colon adenocarcinoma. The metastasis was revealed by the presence of bone metaplasia in the intercostal muscles. We discuss how negative immunostaining for estrogen receptors, progesterone receptors, and HER-2, along with the immunohistochemical pattern of cytokeratin (CK) 20+/7-/5- and CDX2-positive immunostaining, excludes a primary breast malignancy, namely, a "matrix-producing" carcinoma, from the differential diagnosis. We also present the hypothesis of a paracrine pathogenetic mechanism to explain the bone metaplasia

TTF-1/p63-positive poorly differentiated NSCLC: A histogenetic hypothesis from the basal reserve cell of the terminal respiratory unit

TTF-1 is expressed in the alveolar epithelium and in the basal cells of distal terminal bronchioles. It is considered the most sensitive and specific marker to define the adenocarcinoma arising from the terminal respiratory unit (TRU). TTF-1, CK7, CK5/6, p63 and p40 are useful for typifying the majority of non-small-cell lung cancers, with TTF and CK7 being typically expressed in adenocarcinomas and the latter three being expressed in squamous cell carcinoma. As tumors with coexpression of both TTF-1 and p63 in the same cells are rare, we describe different cases that coexpress them, suggesting a histogenetic hypothesis of their origin. We report 10 cases of poorly differentiated non-small-cell lung carcinoma (PD-NSCLC). Immunohistochemistry was performed by using TTF-1, p63, p40 (∆Np63), CK5/6 and CK7. EGFR and BRAF gene mutational analysis was performed by using real-time PCR. All the cases showed coexpression of p63 and TTF-1. Six of them showing CK7+ and CK5/6− immunostaining were diagnosed as “TTF-1+ p63+ adenocarcinoma”. The other cases of PD-NSCLC, despite the positivity for CK5/6, were diagnosed as “adenocarcinoma, solid variant”, in keeping with the presence of TTF-1 expression and p40 negativity. A “wild type” genotype of EGFR was evidenced in all cases. TTF1 stained positively the alveolar epithelium and the basal reserve cells of TRU, with the latter also being positive for p63. The coexpression of p63 and TTF-1 could suggest the origin from the basal reserve cells of TRU and represent the capability to differentiate towards different histogenetic lines. More aggressive clinical and morphological features could characterize these “basal-type tumors” like those in the better known “basal-like” cancer of the breast

Adaptive matrix algebras in unconstrained minimization

In this paper we study adaptive L(k)QNmethods, involving special matrix algebras of low complexity, to solve general (non-structured) unconstrained minimization problems. These methods, which generalize the classical BFGS method, are based on an iterative formula which exploits, at each step, an ad hocchosen matrix algebra L(k). A global convergence result is obtained under suitable assumptions on f