57 research outputs found

    The Economics of Open Source Hijacking and Declining Quality of Digital Information Resources: A Case for Copyleft

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    The economics of information goods suggest the need for institutional intervention to address the problem of revenue extraction from investments in resources characterized by high fixed costs of production and low marginal costs of reproduction and distribution. Solutions to the appropriation issue, such as copyright, are supposed to guarantee an incentive for innovative activities at the price of few vices marring their rationale. In the case of digital information resources, apart from conventional inefficiencies, copyright shows an extra vice since it might be used perversely as a tool to hijack and privatise collectively provided open source and open content knowledge assemblages. Whilst the impact of hijacking on open source software development may be uncertain or uneven, some risks are clear in the case of open content works. The paper presents some evidence of malicious effects of hijacking in the Internet search market by discussing the case of The Open Directory Project. Furthermore, it calls for a wider use of novel institutional remedies such as copyleft and Creative Commons licensing, built upon the paradigm of copyright customisation.Economics of information and knowledge, intellectual property rights, copyright, copyleft, public domain, open source, open content, hijacking, customisation, Creative Commons, DMOZ, search engine, directory.

    Melatonin regulates mesenchymal stem cells differentiation : a review

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    none10Among the numerous functions of melatonin, the control of survival and differentiation of mesenchymal stem cells (MSCs) has been recently proposed. MSCs are a heterogeneous population of multipotent elements resident in tissues such as bone marrow, muscle, and adipose tissue, which are primarily involved in developmental and regeneration processes, gaining thus increasing interest for tissue repair and restoration therapeutic protocols. Receptor-dependent and receptor-independent responses to melatonin are suggested to occur in these cells. These involve antioxidant or redox-dependent functions of this indolamine as well as secondary effects resulting from autocrine and paracrine responses. Inflammatory cytokines and adipokines, proangiogenic/mitogenic stimuli, and other mediators that influence the differentiation processes may affect the survival and functional integrity of these mesenchymal precursor cells. In this scenario, melatonin seems to regulate signaling pathways that drive commitment and differentiation of MSC into osteogenic, chondrogenic, adipogenic, or myogenic lineages. Common pathways suggested to be involved as master regulators of these processes are the Wnt/b-catenin pathway, the MAPKs and the, TGF-b signaling. In this respect melatonin emerges a novel and potential modulator of MSC lineage commitment and adipogenic differentiation. These and other aspects of the physiological and pharmacological effects of melatonin as regulator of MSC are discussed in this review.openLuchetti, Francesca; Canonico, Barbara; Bartolini, Desiree; Arcangeletti, Marcella; Ciffolilli, Silvia; Murdolo, Giuseppe; Piroddi, Marta; Papa, Stefano; Reiter, Russel J.; Galli, FrancescoLuchetti, Francesca; Canonico, Barbara; Bartolini, Desiree; Arcangeletti, Marcella; Ciffolilli, Silvia; Murdolo, Giuseppe; Piroddi, Marta; Papa, Stefano; Reiter, Russel J.; Galli, Francesc

    The economics of open source hijacking and the declining quality of digital information resources: A case for copyleft

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    The economics of information goods suggest the need for institutional intervention to address the problem of revenue extraction from investments in those resources characterized by high fixed costs of production and low marginal costs of reproduction and distribution. Solutions to the appropriation issue, such as copyright, are supposed to guarantee an incentive for innovative activities at the price of few vices marring their rationale. In the case of digital information resources, apart from conventional inefficiencies, copyright shows an extra vice since it might be used perversely as a tool to "hijack" and privatise collectively provided open source and open content knowledge assemblages, even in the case in which the original information was not otherwise copyrightable. Whilst the impact of hijacking on open source software development may be uncertain or uneven, some risks are clear in the case of open content works. The paper presents some evidence of malicious effects of hijacking in the Internet search market by discussing the case of The Open Directory Project. Furthermore, it calls for a wider use of novel institutional remedies such as copyleft and Creative Commons licensing, built upon the paradigm of copyright customisation

    Phantom authority, self-selective recruitment and retention of members in virtual communities: The case of Wikipedia

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    Virtual communities constitute a building block of the information society. These organizations appear capable to guarantee unique outcomes in voluntary association since they cancel physical distance and ease the process of searching for like-minded individuals. In particular, open source communities, devoted to the collective production of public goods, show efficiency properties far superior to the traditional institutional solutions to the public goods issue (e.g. property rights enforcement and secrecy). This paper employs team and club good theory as well as transaction cost economics to analyse the Wikipedia online community, which is devoted to the creation of a free encyclopaedia. An interpretative framework explains the outstanding success of Wikipedia thanks to a novel solution to the problem of graffiti attacks - the submission of undesirable pieces of information. Indeed, Wiki technology reduces the transaction cost of erasing graffiti and therefore prevents attackers from posting unwanted contributions. The issue of the sporadic intervention of the highest authority in the system is examined, and the relatively more frequent local interaction between users is emphasized. The constellation of different motivations that participants may have is discussed, and the barriers-free recruitment process analysed. A few suggestions, meant to encourage long term sustainability of knowledge assemblages, such as Wikipedia, are provided. Open issues and possible directions for future research are also discussed

    The economics of open source hijacking and the declining quality of digital information resources: A case for copyleft

    No full text
    The economics of information goods suggest the need for institutional intervention to address the problem of revenue extraction from investments in those resources characterized by high fixed costs of production and low marginal costs of reproduction and distribution. Solutions to the appropriation issue, such as copyright, are supposed to guarantee an incentive for innovative activities at the price of few vices marring their rationale. In the case of digital information resources, apart from conventional inefficiencies, copyright shows an extra vice since it might be used perversely as a tool to "hijack" and privatise collectively provided open source and open content knowledge assemblages, even in the case in which the original information was not otherwise copyrightable. Whilst the impact of hijacking on open source software development may be uncertain or uneven, some risks are clear in the case of open content works. The paper presents some evidence of malicious effects of hijacking in the Internet search market by discussing the case of The Open Directory Project. Furthermore, it calls for a wider use of novel institutional remedies such as copyleft and Creative Commons licensing, built upon the paradigm of copyright customisation

    Phantom authority, self-selective recruitment and retention of members in virtual communities: The case of Wikipedia

    No full text
    Virtual communities constitute a building block of the information society. These organizations appear capable to guarantee unique outcomes in voluntary association since they cancel physical distance and ease the process of searching for like-minded individuals. In particular, open source communities, devoted to the collective production of public goods, show efficiency properties far superior to the traditional institutional solutions to the public goods issue (e.g. property rights enforcement and secrecy). This paper employs team and club good theory as well as transaction cost economics to analyse the Wikipedia online community, which is devoted to the creation of a free encyclopaedia. An interpretative framework explains the outstanding success of Wikipedia thanks to a novel solution to the problem of graffiti attacks - the submission of undesirable pieces of information. Indeed, Wiki technology reduces the transaction cost of erasing graffiti and therefore prevents attackers from posting unwanted contributions. The issue of the sporadic intervention of the highest authority in the system is examined, and the relatively more frequent local interaction between users is emphasized. The constellation of different motivations that participants may have is discussed, and the barriers-free recruitment process analysed. A few suggestions, meant to encourage long term sustainability of knowledge assemblages, such as Wikipedia, are provided. Open issues and possible directions for future research are also discussed

    Industry 4.0: national and regional comparative advantages in key enabling technologies

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    Industry 4.0 is a name used to indicate a ‘fourth industrial revolution’, characterised by the emergence of smart factories in which cyber-physical systems monitor physical processes and communicate with each other and human beings in real time. European Member States and regions are committed to adapt their innovation systems to the trends of Industry 4.0 and Europe as a whole is facing the challenge of finding a balance between promoting research and innovation excellence and putting less advanced regions in the position to benefit from the ongoing industrial revolution. However, relatively little is known about the magnitude of this economic phenomenon, the comparative advantages of countries and regions and their technological specialisation. We use data from European regions’ participation in collaborative research projects promoted by the 7th Framework Programme for research and innovation to investigate relative and absolute advantages in the enabling technologies of Industry 4.0. Data are regionalised and categorised on the basis of an original taxonomy of technologies developed with the support of a team of European experts in each technological domain. The article also explores regional networks promoted by the Framework Programme and draws policy indications to support the competitiveness of European manufacturing

    What drives the capacity to integrate Industry 4.0 technologies? Evidence from European R&D projects

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    Industry 4.0 is a word that identifies innovative technologies, processes and products, typical of a Fourth Industrial Revolution characterised by a massive and pervasive use of interdependent digital technologies and the rise of cyber-physical spaces or smart factories. European Member States are committed to adapting their innovation systems in order to be able to benefit from Industry 4.0 and the European Commission is also facing the challenge of putting less advanced regions in a position to do so. However, little is known about the drivers of the capacity to compete in the domain of Industry 4.0 by integrating different enabling technologies at the regional level. On the basis of data on regional participation in the 7th European Framework Programme for research and technological development, we investigate the factors underlying the capacity to compete by integrating Industry 4.0 enabling technologies. The evidence shows that EU funding, centrality in research networks and interregional cooperation all play a significant role in technology integration, and these results have important policy implications

    Technological diversity in Europe: empirical evidence from agri-food research projects

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    Technological diversity in Europe: empirical evidence from agri-food research projects. Regional Studies. Regional technological diversity is the capacity of regions to carry out research in multiple technology fields. Based on the analysis of 730 competitive research projects funded by the 7th European Framework Programme in agri-food, we show that the capacity to obtain funding and the regional degree of centrality in collaborative networks promote technological diversity. European programmes for research tend to encourage specialization in peripheral territories and technological diversity in central regions. This has challenging implications for a policy that wants to promote research excellence and, simultaneously, to reduce the wide regional variation in research and innovation performance across the European Union
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