Protein C system in patients with idiopathic pulmonary fibrosis - preliminary report

Wstęp: Układ białka C to naturalny układ antytrombogenny, który może odgrywać istotną rolę w procesie samoistnego włóknienia płuc. Celem pracy było oznaczenie stężenia białka C (PC), białka S (PS), trombomoduliny (TM), selektyny E (sSelE) i kompleksu trombina-antytrombina (TAT) w osoczu krwi chorych na samoistne włóknienie płuc. Materiał i metody: Grupa badanych obejmowała 11 chorych na samoistne włóknienie płuc (średnia wieku 51,5 ± 8,62 rż.). Rozpoznanie ustalono na podstawie objawów klinicznych, badań czynnościowych, radiologicznych, u wszystkich chorych przeprowadzono biopsję otwartą płuca. Grupa kontrolna obejmowała 20 zdrowych ochotników, pierwszorazowych dawców krwi. W osoczu oznaczono stężenie PC, PS, TM, sSelE i TAT metodą immunoenzymatyczną (ELISA). Wyniki: U chorych na samoistne włóknienie płuc zaobserwowano istotnie obniżone stężenia PC (98,24 ± 16,17% vs. 130,59 ± ± 19,03%), PS (71,31 ± 12,95% vs. 93,47 ± 18,63%), TM (2,67 ± 0,40 ng/ml vs. 3,99 ± 1,16 ng/ml) oraz istotnie wyższe stężenie kompleksu TAT (Me = 4,00 mg/ml vs. 2,20 mg/ml) oraz sSelE (Me = 36,40 ng/ml vs. 22,84 ng/ml) w porównaniu z grupą kontrolną. Wniosek: Wstępne obserwacje wskazują, że we krwi chorych na samoistne włóknienie płuc występuje obniżenie potencjału antykoagulacyjnego układu białka C, które może być konsekwencją nasilonej wewnątrznaczyniowej aktywacji procesu krzepnięcia krwi.Introduction: The natural anticoagulant - activated protein C system plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The purpose of this study was to evaluate the concentration of protein C (PC), protein S (PS), thrombomodulin (TM), selectin E (sSelE), and thrombin–antithrombin complex (TAT) in patients with idiopathic pulmonary fibrosis (IPF). Material and methods: Study grup consisted of 11 patients aged 51.5 ± 8.62 years with idiopathic pulmonary fibrosis and 20 healthy adults as control. Concentration of PC, PS TM, sSelE and TAT in plasma with ELISA method was assessed. Results: We observed significantly lower plasma concentration of PC (98.24 ± 16.17% vs. 130.59 ± 19.03%), PS (71.31 ± ± 12.95% vs. 93.47 ± 18.63%), TM (2.67 ± 0.40 ng/ml vs. 3.99 ± 1.16 ng/ml) and significantly higher level of TAT complex (Me = 4.00 mg/ml vs. 2.20 mg/ml) and sSelE (Me = 36.40 ng/ml vs. 22.84 ng/ml) in patients with idiopathic pulmonary fibrosis as compared to controls. Conclusion: In presented pilot study we observed decreased activity of protein C system and increased thrombin generation in peripheral blood of patients with idiopathic pulmonary fibrosis

Opening Access To Practice-based Evidence in Clinical Decision Support Systems with Natural Query Language

Evidence-based medicine can be effective only if constantly tested against errors in medical practice. Clinical record database summarization supported by a machine allows allow to detect anomalies and therefore help detect the errors in early phases of care. Summarization system is a part of Clinical Decision Support Systems however it cannot be used directly by the stakeholder as long as s/he is not able to query the clinical record database. Natural Query Languages allow opening access to data for clinical practitioners, that usually do not have knowledge about articial query languages. Results: We have developed general purpose reporting system called Ask Data Anything (ADA) that we applied to a particular CDSS implementation. As a result, we obtained summarization system that opens the access for these of clinical researchers that were excluded from the meaningful summary of clinical records stored in a given clinical database. The most significant part of the component - NQL parser - is a hybrid of Controlled Natural Language (CNL) and pattern matching with a prior error repair phase. Equipped with reasoning capabilities due to the intensive use of semantic technologies, our hybrid approach allows one to use very simple, keyword-based (even erroneous) queries as well as complex CNL ones with the support of a predictive editor. By using ADA sophisticated summarizations of clinical data are produced as a result of NQL query execution. In this paper, we will present the main ideas underlying ADA component in the context of CDSS

Impact of thermal renovation on selected characteristics of partition walls and the consumption of heat energy

Renovation of multi-family residentials, including mainly thermal renovation, which includes adding thermal insulation, contributes to the improvement of living conditions. Above all, it reduces the operating costs of renovated buildings by reducing the consumption of heat energy for central heating. This article discusses the impact of light wet thermal renovation on the temperature distribution in the vertical cross-section of the partition wall and the calculation value of the temperature on the inner surface of the partition wall, as well as on the reduction of thermal energy consumption in buildings. The subject of the research was residentials erected in the large-panel, large- -block, and traditional technology between 1984 and 1994, managed by Łomża Housing Cooperative (ŁSM)

Protein C System in Patients with Idiopathic Pulmonary Fibrosis—Preliminary Report

Introduction: The natural anticoagulant—activated protein C system plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The purpose of this study was to evaluate the concentration of protein C (PC), protein S (PS), thrombomodulin (TM), selectin E (sSelE), and thrombin–antithrombin complex (TAT) in patients with idiopathic pulmonary fibrosis (IPF). Material and methods: Study grup consisted of 11 patients aged 51.5 ± 8.62 years with idiopathic pulmonary fibrosis and 20 healthy adults as control. Concentration of PC, PS TM, sSelE and TAT in plasma with ELISA method was assessed. Results: We observed significantly lower plasma concentration of PC (98.24 ± 16.17% vs. 130.59 ± 19.03%), PS (71.31 ± ± 12.95% vs. 93.47 ± 18.63%), TM (2.67 ± 0.40 ng/ml vs. 3.99 ± 1.16 ng/ml) and significantly higher level of TAT complex (Me = 4.00 mg/ml vs. 2.20 mg/ml) and sSelE (Me = 36.40 ng/ml vs. 22.84 ng/ml) in patients with idiopathic pulmonary fibrosis as compared to controls. Conclusions: In presented pilot study we observed decreased activity of protein C system and increased thrombin generation in peripheral blood of patients with idiopathic pulmonary fibrosis