1,318 research outputs found
Presentation of Hamlet and Gertrude in Franco Zeffirelli’s Hamlet
Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej nauk
Site Occupancy and Lattice Parameters in Sigma-Phase Co-Cr alloys
Neutron diffraction technique was used to study distribution of Co and Cr
atoms over different lattice sites as well as lattice paramaters in sigma-phase
Co100-xCrx compounds with x = 57.0, 62.7 and 65.8. From the diffractograms
recorded in the temperature range of 4.2 - 300 K it was found that all five
sites A, B, C, D and E are populated by both kinds of atoms. Sites A and D are
predominantly occupied by Co atoms while sites B, C and E by Cr atoms. The unit
cell parameters a and c, hence the unit cell volume, increase with x, the
increase being characteristic of the lattice paramater and temperature. Both a
and c show a non-linear increase with temperature.Comment: 5 figure
Finite time blow-up for radially symmetric solutions to a critical quasilinear Smoluchowski-Poisson system
Finite time blow-up is shown to occur for radially symmetric solutions to a
critical quasilinear Smoluchowski-Poisson system provided that the mass of the
initial condition exceeds an explicit threshold. In the supercritical case,
blow-up is shown to take place for any positive mass. The proof relies on a
novel identity of virial type
Role of purinergic signalling and proinflammatory cytokines in diabetes
Extracellular purines activate P1 adenosine receptors and P2 nucleotide receptors. These receptors are present on the pancreatic islet cells as well as on hepatocytes, adipocytes, pancreatic blood vessels and nerves. ATP is released together with insulin from b-cell granules in response to a rapid decrease in blood glucose levels. The ATP-dependent P2X receptor activation on pancreatic b-cells results in a positive autocrine signal and subsequent insulin secretion. Adenosine, through activation of P1 receptors present on adipocytes and pancreatic islet cells, inhibits the release of insulin. Adenosine activates A2B receptors thereby stimulating production of IL-6 and other cytokines, which increases insulin resistance. Interleukin-6 also plays an important role in diabetes. In type 2 diabetes and obesity, the long-term increase of IL-6 concentration in blood above 5 pg/mL leads to the chronic and permanent increase in expression of SOCS3, contributing to the increase in insulin resistance in cells of the skeletal muscles, liver and adipose tissue. In diabetes there is an increased synthesis and release of pro-inflammatory cytokines, which cause the damage of the pancreatic islet cells, and in type 2 diabetes cause the development of insulin resistance. Ecto-enzymes metabolizing nucleotides are involved in the termination of the nucleotide signalling pathway and play the key role in regulation of extracellular ATP concentration. Ecto-NTPDases in cooperation with 5’-nucleotidase may significantly increase ecto-adenosine concentration. NTPDase3 activity has only been demonstrated on Langerhans cells. NTPDase3 may influence the secretion of insulin by hydrolysing adenine nucleotides. In diabetes the pro-inflammatory cytokines such as interleukin 1b (IL-1b), tumour necrosis factor-a (TNF-a) and interferon-g (IFN-g), as well as pancreatic derived factor PANDER are involved in the apoptosis of pancreatic b-cells. This causes disturbance of the balance between pro-inflammatory and protective cytokines. We believe that neutralization of pro-inflammatory cytokines, especially interleukin 1b, with the IL-1 receptor antagonist (IL-1Ra) and/or IL-1b antibodies might cause the reduction of the inflammatory process in pancreas islets, normalize concentration of glucose in blood and decrease the insulin resistance. (Clin Diabetol 2017; 6, 3: 90–100)Extracellular purines activate P1 adenosine receptors and P2 nucleotide receptors. These receptors are present on the pancreatic islet cells as well as on hepatocytes, adipocytes, pancreatic blood vessels and nerves. ATP is released together with insulin from b-cell granules in response to a rapid decrease in blood glucose levels. The ATP-dependent P2X receptor activation on pancreatic b-cells results in a positive autocrine signal and subsequent insulin secretion. Adenosine, through activation of P1 receptors present on adipocytes and pancreatic islet cells, inhibits the release of insulin. Adenosine activates A2B receptors thereby stimulating production of IL-6 and other cytokines, which increases insulin resistance. Interleukin-6 also plays an important role in diabetes. In type 2 diabetes and obesity, the long-term increase of IL-6 concentration in blood above 5 pg/mL leads to the chronic and permanent increase in expression of SOCS3, contributing to the increase in insulin resistance in cells of the skeletal muscles, liver and adipose tissue. In diabetes there is an increased synthesis and release of pro-inflammatory cytokines, which cause the damage of the pancreatic islet cells, and in type 2 diabetes cause the development of insulin resistance. Ecto-enzymes metabolizing nucleotides are involved in the termination of the nucleotide signalling pathway and play the key role in regulation of extracellular ATP concentration. Ecto-NTPDases in cooperation with 5’-nucleotidase may significantly increase ecto-adenosine concentration. NTPDase3 activity has only been demonstrated on Langerhans cells. NTPDase3 may influence the secretion of insulin by hydrolysing adenine nucleotides. In diabetes the pro-inflammatory cytokines such as interleukin 1b (IL-1b), tumour necrosis factor-a (TNF-a) and interferon-g (IFN-g), as well as pancreatic derived factor PANDER are involved in the apoptosis of pancreatic b-cells. This causes disturbance of the balance between pro-inflammatory and protective cytokines. We believe that neutralization of pro-inflammatory cytokines, especially interleukin 1b, with the IL-1 receptor antagonist (IL-1Ra) and/or IL-1b antibodies might cause the reduction of the inflammatory process in pancreas islets, normalize concentration of glucose in blood and decrease the insulin resistance. (Clin Diabetol 2017; 6, 3: 90–100
Język angielski na stronach internetowych polskich muzeów. Reguła czy wyjątek
Artykuł recenzowany / peer-reviewed articleInformacje dostępne na stronach internetowych mają w turystyce ogromne znaczenie.
Dzięki nim turysta może szczegółowo zaplanować podróż – przyjazna strona internetowa
może wręcz zadecydować o jego wizycie w danym miejscu. Wśród stron, z których
korzystają turyści, znajdują się strony internetowe muzeów. Turysta szuka na nich przede
wszystkim danych o lokalizacji placówki, mapy dojazdu, cen biletów czy godzin otwarcia,
jak również informacji o wystawach. Coraz częściej strony muzeów są jednak czymś
więcej niż tylko wirtualnym informatorem. Wiele instytucji umieszcza w internecie multimedialne
materiały edukacyjne czy digitalizuje swoje zbiory, co umożliwia zapoznanie
się z nimi bez wychodzenia z domu i czyni je dostępnymi dla całego świata.
Celem artykułu jest sprawdzenie, czy strony internetowe polskich muzeów są przygotowane
na wirtualne wizyty anglojęzycznych internautów. Dla potrzeb artykułu przebadano
strony internetowe wybranych muzeów w Polsce pod kątem udostępniania informacji
w języku angielskim. Sprawdzono, czy strona ma wersję anglojęzyczną, czy łatwo moż-
na przełączyć jej wersję językową oraz czy wersja anglojęzyczna odpowiada treściowo
wersji polskojęzycznej, czy przetłumaczono tylko niektóre informacje
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