833 research outputs found
The determination of the global average OH concentration using a deuteroethane tracer
It is proposed to measure the decreasing global concentration of an OH reactive isotopic tracer, G sub 2 D sub 6, after its introduction into the troposphere in a manner to facilitate uniform global mixing. Analyses at the level of 2 x 10 to the -19th power fraction, corresponding to one kg uniformly distributed globally, should be possible by a combination of cryogenic absorption techniques to separate ethane from air and high sensitivity isotopic analysis of ethane by mass spectrometry. Aliquots of C sub 2 D sub 6 totaling one kg would be introduced to numerous southern and northern latitudes over a 10 day period in order to achieve a uniform global concentration within 3 to 6 months by the normal atmospheric circulation. Then samples of air of 1000 l (STP) would be collected periodically at a tropical and temperate zone location in each hemisphere and spiked with a known amount of another isotopic species of ethane, C-13 sub 2 H sub 6, at the level of 10 to the -11th power mole fraction. After separation of the ethanes from air, the absolute concentration of C sub 2 D sub 6 would be analyzed using the Argonne 100-inch radius mass spectrometer
Protein Stabilized and Sustained Deliverable Nanofiber Smart Scaffold for Multiphase Tissue Regeneration
Tissue engineering
(TE) represent a paradigm shift in healthcare
therapies and treatments by repairing,
replacing, or regenerating damaged cells and
tissues in human body.
Chemical cues such
as growth factors (GFs) and cytokines, and
there successful delivery is the key
components in TE with the ability to target
specific tissue regeneration
Protein Stabilized and Sustained Deliverable Nanofiber Smart Scaffold for Multiphase Tissue Regeneration
Tissue engineering
(TE) represent a paradigm shift in healthcare
therapies and treatments by repairing,
replacing, or regenerating damaged cells and
tissues in human body.
Chemical cues such
as growth factors (GFs) and cytokines, and
there successful delivery is the key
components in TE with the ability to target
specific tissue regeneration
Recommended from our members
Expansion of the half retinal projection to the tectum in goldfish: An electrophysiological and Anatomical study
The topographical retino-tectal projection of goldfish was electrophysiologically mapped at various intervals after surgical removal of the nasal half of the retina and pigment epithelium. The remaining projection was initially restricted to the appropriate rostral half of the tectum, even if the nerve was crushed and allowed to regenerate. But later, after 137 days or more, it showed a progressive expansion onto the foreign caudal half of the tectum. The magnification factor, the number of micrometers of tectum per degree in the visual field, doubled in the rostro-caudal but not in the medio-lateral direction. Analysis of the sequence of the expansion showed that a few fibers originally projecting nearest the denervated area were the first to spread over it. Then, progressively more fibers moved caudally until a nearly uniform representation of the half retina was established on the tectum. Radioautography also demonstrated that retinal fiber terminals had invaded the caudal tectum. The retinae of these fish were also examined histologically. The density of ganglion cells had not increased, but they consistently showed the axonal reaction. This was not found to be associated with any initial surgical trauma, but rather with the movement of their fiber terminals within the tectum. Frozen sections, through half retinal and normal eyes, were cut and photographed for comparison of ocular geometry. Operated eyes were normal except for a slight but consistent loss of ocular volume. Analysis of the optical geometry showed that recording with fish in air produced two effects: Myopia (10° blur circle, or less) and enlargement of the visual field by 15% to 20%.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50003/1/901770206_ftp.pd
Positional Encoding by Robots with Non-Rigid Movements
Consider a set of autonomous computational entities, called \emph{robots},
operating inside a polygonal enclosure (possibly with holes), that have to
perform some collaborative tasks. The boundary of the polygon obstructs both
visibility and mobility of a robot. Since the polygon is initially unknown to
the robots, the natural approach is to first explore and construct a map of the
polygon. For this, the robots need an unlimited amount of persistent memory to
store the snapshots taken from different points inside the polygon. However, it
has been shown by Di Luna et al. [DISC 2017] that map construction can be done
even by oblivious robots by employing a positional encoding strategy where a
robot carefully positions itself inside the polygon to encode information in
the binary representation of its distance from the closest polygon vertex. Of
course, to execute this strategy, it is crucial for the robots to make accurate
movements. In this paper, we address the question whether this technique can be
implemented even when the movements of the robots are unpredictable in the
sense that the robot can be stopped by the adversary during its movement before
reaching its destination. However, there exists a constant ,
unknown to the robot, such that the robot can always reach its destination if
it has to move by no more than amount. This model is known in
literature as \emph{non-rigid} movement. We give a partial answer to the
question in the affirmative by presenting a map construction algorithm for
robots with non-rigid movement, but having bits of persistent memory and
ability to make circular moves
Biliverdin Reductase: More than a Namesake – The Reductase, Its Peptide Fragments, and Biliverdin Regulate Activity of the Three Classes of Protein Kinase C
The expanse of human biliverdin reductase (hBVR) functions in the cells is arguably unmatched by any single protein. hBVR is a Ser/Thr/Tyr-kinase, a scaffold protein, a transcription factor, and an intracellular transporter of gene regulators. hBVR is an upstream activator of the insulin/IGF-1 signaling pathway and of protein kinase C (PKC) kinases in the two major arms of the pathway. In addition, it is the sole means for generating the antioxidant bilirubin-IXα. hBVR is essential for activation of ERK1/2 kinases by upstream MAPKK-MEK and by PKCδ, as well as the nuclear import and export of ERK1/2. Small fragments of hBVR are potent activators and inhibitors of the ERK kinases and PKCs: as such, they suggest the potential application of BVR-based technology in therapeutic settings. Presently, we have reviewed the function of hBVR in cell signaling with an emphasis on regulation of PKCδ activity
Dynamical heterogeneities in a supercooled Lennard-Jones liquid
We present the results of a large scale molecular dynamics computer
simulation study in which we investigate whether a supercooled Lennard-Jones
liquid exhibits dynamical heterogeneities. We evaluate the non-Gaussian
parameter for the self part of the van Hove correlation function and use it to
identify ``mobile'' particles. We find that these particles form clusters whose
size grows with decreasing temperature. We also find that the relaxation time
of the mobile particles is significantly shorter than that of the bulk, and
that this difference increases with decreasing temperature.Comment: 8 pages of RevTex, 4 ps figure
Heterogeneous Diffusion in Highly Supercooled Liquids
The diffusivity of tagged particles is demonstrated to be very heterogeneous
on time scales comparable to or shorter than the relaxation time
( the stress relaxation time) in a highly supercooled
liquid via 3D molecular dynamics simulation. The particle motions in the
relatively active regions dominantly contribute to the mean square
displacement, giving rise to a diffusion constant systematically larger than
the Einstein-Stokes value. The van Hove self-correlation function is
shown to have a long distance tail which can be scaled in terms of
for t \ls 3\tau_{\alpha}. Its presence indicates heterogeneous diffusion in
the active regions. However, the diffusion process eventually becomes
homogeneous on time scales longer than the life time of the heterogeneity
structure ().Comment: 4 pages, 5 figure
Trends in source gases
Source gases are defined as those gases that, by their breakdown, introduce into the stratosphere halogen, hydrogen, and nitrogen compounds that are important in stratospheric ozone destruction. Given here is an update of the existing concentration time series for chlorocarbons, nitrous oxide, and methane. Also reviewed is information on halogen containing species and the use of these data for establishing trends. Also reviewed is evidence on trends in trace gases that influence tropospheric chemistry and thus the tropospheric lifetimes of source gases, such as carbon dioxide, carbon monoxide, or nitrogen oxides. Much of the information is given in tabular form
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