1,325 research outputs found
Combined action of SAMe, Folate, and Vitamin B12 in the treatment of mood disorders: a review.
Mood disorders affect more than 500 million people around the world. In the last decade, their prevalence has increased, and many people suffer from nervousness, anxiety, and stress at least once in their lives. The incidence of mood disorders and anxiety increases during perimenopause or under stressful conditions. The social restrictions introduced during the COVID-19 pandemic have significantly increased the normal burden of psychological and psychic disorders. In moderate to severe cases, pharmacological treatment is currently recommended, while in mild disorders, especially in the initial phase, psychological therapy is preferable. It is known that several nutrients are crucial for brain function. Among them, folate (vitamin B9), cyanocobalamin (vitamin B12), and S-adenosyl-L-methionine (SAMe) have been shown to influence various neurobiological processes. Overall, the available evidence suggests that dietary supplementation with folic acid, vitamin B12, and SAMe can be beneficial for people with mild mood disorders
Tuning the potential drop at graphene/protic ionic liquid interface by molecular structure engineering
Ionic liquids (ILs) have been extensively employed in many applications involving interfaces with carbon-based electrodes, such as energy storage devices (batteries or supercapacitors) or electrocatalytic devices, where the way each ion of the IL interacts with the electrode has a strong impact on the overall performance of the device. For instance, the amount of potential difference between the electrode and the bulk of the IL is highly sensitive to the IL composition and it is directly related to the device capacitance. The selection of the most suited pair of ions often proceeds by time-consuming and costly trial-and-error approaches. It is necessary to understand the atomistic features of the interface to determine the effect of each ion on the potential drop. By classical molecular dynamics simulations, we show that it is possible to quickly infer the interface potential arising at the carbon electrode by carefully inspecting the molecular structure of the IL. The ion orientation at the interface is, in fact, determined by the distribution of charges within the molecules. Depending on where charges are located, ions can either lie flat or perpendicular to the interface to minimize the surface energy. The interface potential is found to be mainly determined by ion-ion interactions dictating the interface energy minimization process, whereas ion-electrode interactions are found to enforce higher ordering and charge layers stacking but not to induce selective adsorption of an ion over the other
Triptans: the experience of a clinical pharmacologist in clinical practice.
Despite the pharmacokinetic differences among triptans and the variety of ways of administration, the clinical differences in every day use of these drugs lack in an accepted decisional tree. In fact,
there are a number of comparative trials showing conflicting results with regard to efficacy, onset of action, safety and ecurrence incidence. That means that the patientâs preference probably is the main criterion for choosing one triptan vs. others. This point of view is probably correct considering also that the
main cause of therapy failure is noncompliance.
A good migraine care strategy requires a balance in what the patient views as satisfactory, a reasonable compromise between
efficacy and tolerability, and a careful follow-up. Improvement in compliance should be the main and more immediate goal for the treatment of migraine attacks
Dietary interventions in blood pressure lowering: Current evidence in 2020
Dietary modification is one of the cornerstones in the treatment of arterial hypertension (AH). Current American and European guidelines recommend people to ingest fruit, vegetables, whole grains, and low-fat dairy products as well as to decrease the consumption of red meat, sugar, and trans fats. This review aimed to summarize available evidence on dietary patterns associated with lower blood pressure (BP). Research has shown that the Dietary Approach to Stop Hypertension (DASH) diet can lower BP equally effectively or even more significantly than some antihypertensive drugs. The Mediterranean diet also leads to a considerable reduction in BP. Vegans and vegetarians have been shown to have a lower prevalence of AH than omnivores. Caloric restriction may decrease BP in normotensive, prehypertensive, and hypertensive populations. Blood pressure can also be lowered by certain nutraceuticals (such as beetroot juice, magnesium, vitamin C, catechin-rich beverages, or soy isoflavones). Diet effects on BP are mediated by body weight loss, amelioration of inflammation, increased insulin sensitivity, and antihypertensive properties of some individual nutrients. There is robust evidence that vegetarian and vegan diets have the ability to reduce BP. The presence of the so-called floor effect makes these diets usable in normo- and prehypertensive people at high risk of developing AH. However, the dietary and nutraceutical approach to BP lowering cannot substitute drug treatment when the latter is needed
Clinical Effects of Xanthine Oxidase Inhibitors in Hyperuricemic Patients.
open5noThis review aims to critically present the available clinical evidence supporting the treatment of chronic hyperuricemia with xanthine oxidase inhibitors. For this reason, the studies published on uric acid (UA)-lowering drugs in the English language from 2000 to August 2019 have been carefully reviewed. The terms "serum uric acid," "xanthine oxidase," "allopurinol," "febuxostat," and "topiroxostat" were incorporated into an electronic search strategy, alone and in combinations, in both MEDLINE (National Library of Medicine, Bethesda, MD) and the Cochrane Register of Controlled Trials (The Cochrane Collaboration, Oxford, UK). Even if new urate-lowering drugs seem of particular efficacy for acute treatment of refractory hyperuricemia, their use is supported by relatively small clinical evidence. On the contrary, large long-term clinical trials have demonstrated that xanthine oxidase inhibitors (XOIs, namely, allopurinol and febuxostat) are effective, safe, and relatively well-tolerated in most of the patients. They have mainly been tested in the elderly, in patients affected by chronic diseases such as heart failure and cancer, and in patients taking a large number of drugs, confirming their safety profile. Recent data also show that they could exert some positive effects on vascular health, renal function, and glucose metabolism. Their cost is also low. In conclusion, XOIs remain the first choice of UA-lowering drug for chronic treatment.openCicero AFG, Fogacci F, Cincione RI, Tocci G, Borghi C.Cicero AFG, Fogacci F, Cincione RI, Tocci G, Borghi C
Development of a rapid and eco-friendly UHPLC analytical method for the detection of histamine in fish products
We developed, validated, and confirmed with proficiency tests a fast ultra-high-performance liquid chromatography with diode array detector (UHPLC-DAD) method to determine histamine in fish and fishery products. The proposed method consists of two successive solidâliquid extractions: one with a dilute solution of perchloric acid (6%) and the second only with water. The instrumental analysis with UHPLC provides a very fast run time (only 6 min) with a retention time of approximately 4 min, a limit of quantification (LOQ) of 7.2 mg kgâ1, a limit of detection (LOD) of 2.2 mg kgâ1, a recovery around 100%, a relative standard deviation (RSD%) between 0.5 and 1.4, and an r2 of calibration curve equal to 0.9995. The method detected optimal values of the validation parameters and required a limited number of reagents in comparison to other methods reported in the literature. Furthermore, the method could detect histamine in a very short time compared with other methods. This method, in addition to being validated, precise, specific, and accurate, avoids wasting time, money, and resources, and limits the use of organic solvents
High-speed data transfer with FPGAs and QSFP+ modules
We present test results and characterization of a data transmission system
based on a last generation FPGA and a commercial QSFP+ (Quad Small Form
Pluggable +) module. QSFP+ standard defines a hot-pluggable transceiver
available in copper or optical cable assemblies for an aggregated bandwidth of
up to 40 Gbps. We implemented a complete testbench based on a commercial
development card mounting an Altera Stratix IV FPGA with 24 serial transceivers
at 8.5 Gbps, together with a custom mezzanine hosting three QSFP+ modules. We
present test results and signal integrity measurements up to an aggregated
bandwidth of 12 Gbps.Comment: 5 pages, 3 figures, Published on JINST Journal of Instrumentation
proceedings of Topical Workshop on Electronics for Particle Physics 2010,
20-24 September 2010, Aachen, Germany(R Ammendola et al 2010 JINST 5 C12019
A rare case of extra-intramedullary dorsal tanycitic ependymoma, radically removed with intraoperative neurophysiological monitoring
Introduction: Tanycitic dorsal extra and intramedullary ependymoma is a rare form of tumor. From the histological point of view, these tumors show several aspects that make difficult the differential diagnosis from schwannomas and pilocytic astrocytomas. Tanycytic variant, often occurs in the thoracic tract of the spinal cord, and it is constituted by tanycites, that are typical elongated and bipolar cells that give to the tumor fibrillary aspects. Tanycitic variant has been recently characterized as a variant of ependymoma, since the 2000 World Health Organization (WHO) system. Case presentation: A 57 years old woman presented with intractable back pain often radiating to the left leg. Neurological exam revealed mild weakness in left tight flexion. No sensory or sphincterial disturbances were present. A dorso-lumbar Magnetic Resonance Imaging (MRI)with contrast medium showed a well-demarked T12 intradural extramedullary lesion, suggestive for schwannoma. The tumor was radically removed, with an excellent neurological outcome, and was then characterized as a grade II tanycitic ependymoma. Conclusion: To differentiate the diagnosis between extramedullary ependymomas and schwannomas, meningiomas or astrocytomas is necessary a histopathological examination and a close follow up period is recommended since the tumor could evolve into higher grade. Neurophysiological monitoring is necessary for a satisfactory neurological outcome
A rare case of extra-intramedullary dorsal tanycitic ependymoma, radically removed with intraoperative neurophysiological monitoring
Introduction: Tanycitic dorsal extra and intramedullary ependymoma is a rare form of tumor. From the histological point of view, these tumors show several aspects that make difficult the differential diagnosis from schwannomas and pilocytic astrocytomas. Tanycytic variant, often occurs in the thoracic tract of the spinal cord, and it is constituted by tanycites, that are typical elongated and bipolar cells that give to the tumor fibrillary aspects. Tanycitic variant has been recently characterized as a variant of ependymoma, since the 2000 World Health Organization (WHO) system. Case presentation: A 57 years old woman presented with intractable back pain often radiating to the left leg. Neurological exam revealed mild weakness in left tight flexion. No sensory or sphincterial disturbances were present. A dorso-lumbar Magnetic Resonance Imaging (MRI)with contrast medium showed a well-demarked T12 intradural extramedullary lesion, suggestive for schwannoma. The tumor was radically removed, with an excellent neurological outcome, and was then characterized as a grade II tanycitic ependymoma. Conclusion: To differentiate the diagnosis between extramedullary ependymomas and schwannomas, meningiomas or astrocytomas is necessary a histopathological examination and a close follow up period is recommended since the tumor could evolve into higher grade. Neurophysiological monitoring is necessary for a satisfactory neurological outcome
Administration of protein hydrolysates from anchovy (Engraulis encrasicolus) waste for twelve weeks decreases metabolic dysfunctionâassociated fatty liver disease severity in ApoEâ/âmice
Metabolic dysfunctionâassociated fatty liver disease (MAFLD) includes several diseases, ranging from simple steatosis to steatohepatitis, fibrosis and cirrhosis. Fishârich diets are considered helpful in the prevention of MAFLD, and the enzymatic hydrolysis of fish waste has been explored as a means of obtaining highâvalue protein hydrolysates, which have been proven to exert beneficial bioactivities including antiâobesity and hypocholesterol effects. This study aimed to assess the effect of the administration of protein hydrolysates from anchovy waste (APH) for 12 weeks on attenuated highâfat dietâinduced MAFLD in apolipoprotein Eâknockout mice (ApoEâ/â). Thirty ApoEâ/â mice were divided into two groups (n = 15/group) and fed a highâfat diet (HFD), with and without the addition of 10% (w/w) APH. After 12 weeks, serum and hepatic lipid profiles, hepatic enzyme activities, liver histology and immunohistochemistry were analyzed to assess hepatic steatosis, inflammation and fibrosis. Twelveâweeks on a 10% (w/w) APH diet reduces total cholesterol and triglyceride serum levels, hepatic enzyme activity and hepatic triacylglycerol content (p < 0.0001), and results in a reduction in hepatic fat accumulation and macrophage recruitment (p < 0.0001). The results suggest that a 10% APH diet has an antiâobesity effect, with an improvement in lipid metabolism, hepatic steatosis and liver injury as a result of a highâfat diet. Protein hydrolysates from fish waste may represent an efficient nutritional strategy in several diseases, and their use as nutraceuticals is worthy of future investigation
- âŠ