520 research outputs found
Impact of nutritional vitamin D supplementation on parathyroid hormone and 25-hydroxyvitamin D levels in non-dialysis chronic kidney disease : a meta-analysis
Background. Secondary hyperparathyroidism (SHPT) is a common and major complication in chronic kidney disease (CKD), reflecting the increase of parathyroid hormone (PTH) in response to reduced vitamin D signalling and hypocalcaemia. This meta-analysis evaluated the impact of nutritional vitamin D (NVD) (cholecalciferol or ergocalciferol) on SHPT-related biomarkers. Methods. A systematic literature search was performed in PubMed to identify relevant randomized control trials to be included in the meta-analysis. Fixed- and random-effects models were used to pool study-level results. Effects were studied within NVD study arms and relative to control groups (placebo/no treatment); the former in order to identify the effect of actively altering biomarkers levels. Results. Reductions in PTH from supplementation with NVD were small when observed within the NVD study arms (pooled reduction: 10.5 pg/mL) and larger when compared with placebo/no treatment (pooled reduction: 49.7 pg/mL). NVD supplementation increased levels of 25-hydroxyvitamin D [25(OH)D] in both analyses (increase within NVD study arm: 20.6 ng/mL, increase versus placebo/no treatment: 26.9 ng/mL). While small and statistically non-significant changes in phosphate and fibroblast growth factor 23 were observed, NVD supplementation caused calcium levels to increase when compared with placebo/no treatment (increase: 0.23 mg/dL). Conclusions. Our results suggest that supplementation with NVD can be used to increase 25(OH)D to a certain extent, while the potential of NVD to actively reduce PTH in non-dialysis-CKD patients with SHPT is limited
Correlated defects, metal-insulator transition, and magnetic order in ferromagnetic semiconductors
The effect of disorder on transport and magnetization in ferromagnetic III-V
semiconductors, in particular (Ga,Mn)As, is studied theoretically. We show that
Coulomb-induced correlations of the defect positions are crucial for the
transport and magnetic properties of these highly compensated materials. We
employ Monte Carlo simulations to obtain the correlated defect distributions.
Exact diagonalization gives reasonable results for the spectrum of valence-band
holes and the metal-insulator transition only for correlated disorder. Finally,
we show that the mean-field magnetization also depends crucially on defect
correlations.Comment: 4 pages RevTeX4, 5 figures include
World small animal veterinary association renal pathology initiative: classification of glomerular diseases in dogs
Occurrence, management and outcome of immune-complex glomerulonephritis in dogs with suspected glomerulopathy in the UK
First Observation of -odd Asymmetry in Polarized Neutron Capture on Hydrogen
We report the first observation of the parity-violating 2.2 MeV gamma-ray
asymmetry in neutron-proton capture using polarized cold
neutrons incident on a liquid parahydrogen target at the Spallation Neutron
Source at Oak Ridge National Laboratory. isolates the , \mbox{} component of the weak
nucleon-nucleon interaction, which is dominated by pion exchange and can be
directly related to a single coupling constant in either the DDH meson exchange
model or pionless EFT. We measured , which implies a DDH weak coupling of
and a pionless
EFT constant of MeV. We describe the experiment, data
analysis, systematic uncertainties, and the implications of the result.Comment: 6 pages, 5 figure
Nab: Measurement Principles, Apparatus and Uncertainties
The Nab collaboration will perform a precise measurement of 'a', the
electron-neutrino correlation parameter, and 'b', the Fierz interference term
in neutron beta decay, in the Fundamental Neutron Physics Beamline at the SNS,
using a novel electric/magnetic field spectrometer and detector design. The
experiment is aiming at the 10^{-3} accuracy level in (Delta a)/a, and will
provide an independent measurement of lambda = G_A/G_V, the ratio of
axial-vector to vector coupling constants of the nucleon. Nab also plans to
perform the first ever measurement of 'b' in neutron decay, which will provide
an independent limit on the tensor weak coupling.Comment: 12 pages, 6 figures, 1 table, talk presented at the International
Workshop on Particle Physics with Slow Neutrons, Grenoble, 29-31 May 2008; to
appear in Nucl. Instrum. Meth. in Physics Research
The Nab Experiment: A Precision Measurement of Unpolarized Neutron Beta Decay
Neutron beta decay is one of the most fundamental processes in nuclear
physics and provides sensitive means to uncover the details of the weak
interaction. Neutron beta decay can evaluate the ratio of axial-vector to
vector coupling constants in the standard model, , through
multiple decay correlations. The Nab experiment will carry out measurements of
the electron-neutrino correlation parameter with a precision of and the Fierz interference term to
in unpolarized free neutron beta decay. These results, along with a more
precise measurement of the neutron lifetime, aim to deliver an independent
determination of the ratio with a precision of that will allow an evaluation of and sensitively
test CKM unitarity, independent of nuclear models. Nab utilizes a novel, long
asymmetric spectrometer that guides the decay electron and proton to two large
area silicon detectors in order to precisely determine the electron energy and
an estimation of the proton momentum from the proton time of flight. The Nab
spectrometer is being commissioned at the Fundamental Neutron Physics Beamline
at the Spallation Neutron Source at Oak Ridge National Lab. We present an
overview of the Nab experiment and recent updates on the spectrometer,
analysis, and systematic effects.Comment: Presented at PPNS201
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