Assessment of intracellular zinc levels in infants with food protein-induced allergic proctocolitis

Background: Food protein-induced allergic proctocolitis (FPIAP) is characterized by bloody stools in well-appearing infants. Zinc is a micronutrient that plays a crucial role in immune modulation and is essential for cellular function during immune response. Although there are studies on the assessment of intracellular zinc levels in allergic diseases, no data is available on erythrocyte zinc levels of patients with FPIAP. Objective: This study aimed to assess the erythrocyte zinc levels of children with allergic proctocolitis and compare zinc levels with clinical and demographic characteristics. Methods: This was a case-control study that prospectively compared 50 patients with FPIAP and 50 healthy children without malnutrition. The erythrocyte zinc levels of children were determined using atomic absorption spectrophotometry. Results: Fifty patients with FPIAP, including 28 (51%) girls, with median age of 7.1 +/- 2.9 (3-14) months and 50 healthy children, including 26 (53.1%) girls, with median age of 7.7 +/- 2.8 (3-13) months were included in the study. Seventy percent (n = 35) of the patients with FPIAP started to have symptoms while they were exclusively breastfeeding. Offending allergen foods were cow's milk (78%), egg (40%), sesame (10%), hazelnut (8%), almond (6%), beef (6%), and peanuts (6%, n = 3). Intracellular (erythrocyte) zinc levels in patients with FPIAP were lower than in the healthy control group (495.5 +/- 134 mu g/dL, 567.3 +/- 154.4 mu g/dL, respectively, P = 0.01). Patients with FPIAP aged younger than 6 months had lower intracellular zinc levels compared with those aged above 6 months (457 +/- 137 mu g/dL; 548 +/- 112 mu g/dL, respectively, P = 0.01). There was no relationship between zinc levels and time of symptom onset, presence of concomitant disease, being allergic to multiple foods, and family history of atopy (P > 0.05). Conclusions: FPIAP is a food allergy with limited information on its pathogenesis. Considering the beneficial effects on gastrointestinal system epithelia, zinc may be involved in the patho-genesis of FPIAP. Future comprehensive prospective research on this subject is of importance. (c) 2023 Codon Publications. Published by Codon Publications

Eisenia hortensis sölomositlerinde bentazone ve chloridazon herbisitlerinin genotoksisitesinin değerlendirilmesi

In current study, genotoxic effects of Bentazone and Chloridazon herbicides on Eisenia hortensis species were investigated. The species of E. hortensis were collected from the natural habitats in Afyonkarahisar. Comet assay and Micronucleus test was conducted to evaluate the genotoxicity in earthworm coelomocytes. The LD50 value of Bentazone herbicides was noted as 236 ppm and 76.6 ppm for Chloridazon, respectively. Then LD50/2, LD50 and 2XLD50 concentrations of Bentazone and Chloridazon herbicides were applied to E. hortensis for 48 h. Concentration dependent increase in DNA and chromosomal damage was observed (P < 0.05) by both herbicides. Highest DNA damage and micronucleus formation were noticed at highest doses compared to other concentrations and control group. It was concluded that Bentazone and Chloridazon induced DNA damage and chromosomal aberrations failure in E. hortensis earthworms.Bu çalışmada, Bentazone ve Chloridazon herbisitlerinin Eisenia hortensis türleri üzerindeki genotoksik etkileri araştırılmıştır. E. hortensis türleri Afyonkarahisar'daki doğal yaşam alanlarından toplanmıştır. Solucan sölomositlerinde genotoksisiteyi değerlendirmek için Comet ve Mikronükleus testi yapıldı. Bentazone herbisitlerin LD50 değeri Chloridazon için sırasıyla 236 ppm ve 76.6 ppm olarak kaydedildi. Daha sonra LD50/2, LD50 and 2XLD50 konsantrasyonlarında Bentazon ve Chloridazon herbisitleri E. hortensis'e 48 saat süreyle uygulandı. Her iki herbisitte de DNA'da konsantrasyona bağlı artış ve kromozomal hasar gözlendi (P <0.05). En yüksek DNA hasarı ve kromozomal sapmaları, diğer konsantrasyonlara ve kontrol grubuna kıyasla en yüksek dozlarda tespit edildi. Bentazone ve Chloridazon'un E. hortensis’ te DNA hasarı ve kromozomal sapmalara neden olduğu sonucuna varılmıştır

INVESTIGATION OF THE RELATIONSHIP BETWEEN PROSPECTIVE TEACHERS' ATTITUDES TOWARDS MOBILE LEARNING AND THEIR READINESS FOR MOBILE LEARNING

The aim of this research is to investigate the relationship between prospective classroom teachers' attitudes towards mobile learning and their mobile learning readiness levels. For this purpose, data were collected from prospective teachers using the Mobile Learning Readiness and Attitudes towards Mobile Learning scales, and the relationships between the dimensions that determine the scale levels of pre-service teachers were examined through correlation and regression analyses. T-test, one-way analysis of variance (ANOVA) and post hoc (Tukey, LSD) analyses were used to examine the differences in scale levels according to the descriptive characteristics of pre-service teachers. As a result of the study, it was found that the attitude towards mobile learning increased the general level of mobile learning readiness. The attitudes, satisfaction, impact on learning, motivation, and usefulness scores of prospective teachers towards mobile learning do not differ according to gender, the status of education studied via mobile learning. However, it has been found that there is a significant difference according to the internet access status. As a result of the research, it can be suggested that the internet infrastructure of universities should be improved, and prospective teachers should be encouraged to use mobile learning tools

ASSESSMENT OF CYTOTOXICITY OF A CAFFEINATED SOFT DRINK USING ALLIUM ASSAY

One of the most consumed caffeinated soft drinks by millions of people globally is Coca-Cola. For healthy adults, caffeine consumption is relatively safe, but for some vulnerable populations, caffeine consumption could be harmful. Therefore, we considered this cytogenetic study to be appropriate for assessment of cytotoxicity effects of Coca-Cola in meristematic cells of plants, through Allium test. A. cepa has assayed to be one of the best model plants for standard use in cytological analysis of different toxins for their cytotoxicity and genotoxicity to plants and animals. The meristematic roots were treated with various concentrations of Coca-Cola (3, 5 and 10ml/cl) for 8 hours, at room temperature, along to an untreated control. It was found that Coca-Cola induced a strong cytogenotoxic effect in meristematic cells of A. cepa as the concentration of Coca-Cola was increased. The clastogenic and aneugenic effect of the tested product was manifested by the decrease of mitotic index (12.5-3.5%) and the occurrence of several types of chromosomal and nuclear abnormalities (12.6-23.2%): bridges, laggards, stickiness and disrupted nucleus. These results suggest that the caffeinated soft drinks can be harmful to health and their regular intake must be avoided. The problem can arises when the consumption is regularized in everyday life, as, unfortunately, many people do

ALAD (&#948;-aminolevulinic Acid Dehydratase) as Biosensor for Pb Contamination

Non

Current Approach To Cow's Milk Allergy

Cow milk allergy (CMA) is the most common food allergy in infants and young children, its frequency is reported as 1.8-7.5% in different studies and 80% of these patients will develop tolerance by the age of 6 years. Cows milk allergy is defined as an adverse reaction caused by an abnormal immunological response to CM proteins (β-lactoglobulin, casein,etc.). In clinical, 32-60% of children with CMA presents with gastrointestinal symptoms, 5-90% with skin symptoms and anaphylaxis in 0.8 to 9% of cases. It’s important that current diagnosis of CMA, depends on evaulating clinical findings, skin tests (skin prick test and atopy patch test), milk specifik-IgE assays which only indicate sensitisation and oral food challenge test as a gold standart. The current treatment option for CMA is still elimination diet of food including CM proteins until developing tolerance. For the reason, due to risk of accidental ingestion and clinical reactions like anaphylaxis, patients and families had to be informed about the foods including cow’s milk proteins and alternative food sources; risk analysis and emergincy plan must be made individualy. However, oral immunoterapy is one of the treatment options for children from around 4 - 5 years of age with persistent IgE-mediated CMA it must be administered only by experienced centers currently. Patient with CMA should be evaluated for tolerance development regularly, during the elimination diet

Üstün yetenekli olan veya olmayan ergenlerde benlik saygısı, başkalarının algılaması ve psikolojik belirtiler arasındaki ilişkiler

06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Araştırmanın temel amacı, üstün yetenekli olan ve olmayan ergenlerde benlik saygısı vebaşkaları tarafından algılanmaya ilişkin düşüncelerin psikolojik belirtiler üzerindeki etkisiniaraştırmak ve üstün yetenekli ergenlerin kişilik gelişimlerine katkıda bulunabilecek önerilerdebulunabilmektir.Araştırmada aşağıdaki sorulara cevap aranmıştır:- Üstün yetenekli olan ve olmayan ergenlerin benlik saygısı ve başkaları tarafından algılanmayailişkin düşünceleri demografik özelliklerine göre değişmekte midir?- Üstün yetenekli olan ve olmayan ergenlerin psikolojik belirti düzeyleri ile demografiközelliklerine göre değişmekte midir?- Üstün yetenekli olan ve olmayan ergenlerin benlik saygısı ile başkaları tarafından algılanmayailişkin düşünceleri arasında fark var mıdır?Araştırmada öncelikle konu ile ilgili literatür taraması yapılmıştır.Araştırma konusuyla ilgiliverileri ulaşabilmek amacıyla Rosenberg Benlik Saygısı Envanterinin benlik saygısı alt ölçeği(Çuhadaroğlu), Kısa Semptom Envanteri (Şahin ve Durak) ve araştırmacı tarafından hazırlananbilgi formu kullanılmıştır.Araştırmadan elde edilen veriler ?SPSS 11,5? paket programındanyararlanılarak, varyans anlizi, t testi ve Pearson Momentler Çarpımı Korelasyon tekniklerikullanılarak analiz edilmiş ve tüm veriler .05 düzeyinde test edilmiştir.Araştırmanın bulgularından elde edilen sonuçlara göre;Üstün yetenekli ergenlerde normal akranlarına oranla başkalarının kendilerine ilişkin olumlufikirlere sahip oldukları düşüncesi daha yaygındır. Üstün yetenekli ergenlerin normallere göredepresyon, somatizasyon, obsesif-kombusif bozukluk, paranoya ve psikotizm gibi psikolojikbelirtileri taşıma olasılığının daha fazla olduğu görülmüştür. Ayrıca araştırma grubunungenelinde kızların erkeklere oranla depresyon, obsesif-kombusif bozukluk, kişiler arasıduyarlılık ve anksiyete düzeylerinin daha fazla olduğu bulunmuştur. Annenin eğitim durumu ilepsikolojik belirtiler arasında anlamlı bir fark bulunmuştur.Gelir durumunun anksiyete düzeyiüzerinde etkili olduğu görülmüştür. Sonuçlar üstün yetenekli öğrenciler açısından tartışılmıştır.Anahtar Kelimeler:Üstün yeteneklilik, Benlik Saygısı, Başkaları tarafından Algılanma,Psikolojik Belirtiler.The main aim of the research is about the adlescents who are gifted or not self-esteem and tosearc effects on pyscholojic indications related with thoughts that is perceived by the others andto propose about gifted adolescents? personality developments.In this research the questions below had been necessary to answers:- Do the adolescents?, who are gifted or not, personality respect and the thoughts related withbeing perceived change according to their demographic features?- Do the adolescents?, who are gifted or not, levels of pyscholojic indications change accordingto their demographic features?- Are they any differences between the adolescents?, that are gifted or not, personality respectand the thoughts related with being perceived by the others?In this research firstly, literature research about the subject had been done. In order to reach thedatas related with the research subjectRosenberg Belf-Esteem Inventory?s personality respectlower scale ( Çuhadaroğlu), Short Symptom Inventory ( Şahin ve Durak) and the InformationForm that had been prepared by the researcher had been used. The datas, that had been obtainedfrom the research, had been analysed by using ?SPSS 11,5? package program and variansanalysis, t test, Pearson Moments Multiplication Correlation technigues so all datas had beentested at .05 level.Acording to the results that had been obtained from the research findings; It is more commonthat gifted adolescents have idea about the other? thoughts pozitive against themselves if wecompare them with their normal of the same age. It had been seen that the possibility of carryingpyscholojic indications at gifted adolescents like depression, somatization, obsessive -kombusive disorder, paranoia and psikotizm are more than the normal adolescents. Besides ingeneral of the research group, it had been found that the girls have more depression, obsessive -kombusive disorder among individuals sensitivity and their anksiyete levels are much morethan the boys. A meaningful difference had been found between the mother?s educationsituation and the pyscholojical indications. It had been seen that income situtations has an effecton anksiyete level. The results had been discussed on gifted children.Anahtar Kelimeler:Giftedness, Self Esteem, Being Perceived by Others, Pyscholojicndication

Novel functional copolymers based on glycidyl methacrylate: Synthesis, Characterization, and Polymerization kinetics

A new methacrylate monomer 2-(4-nitrophenyl)-2-oxoethyl-2-methacrylate (NFM) was synthesized and its radical copolymerization with glycidyl methacrylate (GMA) was studied in 1,4-dioxane solution at 65 C using 2,2 0 -azobisisobutyronitrile as an initiator. The synthesized monomer and copolymers were characterized by FTIR, 1 H and 13 C-NMR spectroscopy. The analysis of reactivity ratios revealed that NFM is less reactive than GMA, and copolymers formed are statistically in nature. Thermogravimetric analysis of the polymers reveals that the thermal stability of the copolymers increases with an increasing in the mole fraction of NFM in the copolymers. Glass transition temperatures of the copolymers decreased with an increasing of NFM molar fraction in copolymers. In addition, according to the results obtained from the contact angle and zeta potential measurements the hydrophobic character of the polymer decreases (it means surface free energy increases) and its zeta potential becomes more negative with increase of NFM ratio in the copolymer. Polymers with carbonyl functional groups have been particularly interesting because of their use as photoresists.AKÜ-BAPK / 14-FENED-0

Dijital ve Basılı Okumaya Yönelik Tutum Ölçeği: Türkçeye Uyarlama, Geçerlik ve Güvenirlik Çalışması

Bu araştırmada Dijital ve Basılı Okumaya Yönelik Tutum Ölçeğinin Türkçeye uyarlanması amaçlanmıştır. Bu doğrultuda öncelikle ölçeği uyarlamak için gerekli izinler alınmıştır. Gerekli izinler alındıktan sonra ölçek uyarlama aşamalarına göre dil ve alan uzmanları tarafından çeviri işlemleri yapılıp dil geçerliliği sağlanmaya çalışılmıştır. Dil geçerliliği sağlanınca ölçek uygulamaya hazır hale getirilip 9-11 yaş arası 279 öğrenciden oluşan çalışma grubuna uygulanmıştır. Uygulama sonrası geçerlik ve güvenirlik çalışmaları yapılmıştır. Ölçeğin orijinal formunda açımlayıcı faktör analizi sonucu belirlenen üç faktörlü yapı, Türkçeye çevrilen form aracılığıyla 279 kişiden elde edilen veriler üzerinden analiz edilmiştir. Doğrulayıcı faktör analizi kapsamında üç faktörlü yapıya ilişkin hesaplanan RMSEA, RMR, X2/sd, GFI, CFI, NNFI uyum indekslerinin iyi düzeyde olduğu belirlenmiştir. Ölçeğin güvenirliğinin belirlenmesi için Cronbach alfa katsayısı hesaplanmış ve bu katsayı ölçeğin bütünün de .80; üç faktör bazında ise sırasıyla .60, .70 ve .74 olarak ölçülmüştür. Bu bulgular sonucunda güvenirlik katsayılarının, birinci faktör için kabul edilebilir, ikinci ve üçüncü faktörler içinse iyi düzeyde olduğu tespit edilmiştir. Araştırmada elde edilen sonuçlar Türkçeye uyarlanan Dijital ve Basılı Okumaya Yönelik Tutum Ölçeğinin geçerlik ve güvenirliğine ilişkin kanıtlar sunmaktadır

Investigation of Different Training Methods Integrated into Soccer Training on Body Composition and Athletic Performance

Background and Study Aim. The aim of the study is to investigate the effects of 8-week core and plyometric training on body composition and athletic performance in young male soccer players. Material and Methods. 24 young male soccer players participated in the study voluntarily. The subjects were randomly divided into three separate groups: Core training group (CTG), plyometric training group (PTG) and control group (CG). In addition to soccer training two days a week for 8 weeks, the training was applied to the subjects according to the training programs determined. Physical and performance measurements were made 8 weeks before and after the study. Subject's measurements were analyzed in the SPSS 22 program. Results. The largest percentage and significant difference in agility, speed, vertical jump and plyometric jump parameters was obtained in PTG, while the largest percentage and significant difference in horizontal jump parameters was obtained in CTG. While no difference was found in speed and agility performance in CTG; there are significant differences in jump performance but these differences are lower than the other experimental groups in terms of percentage difference. On the other hand in body composition, a significant change was observed only in the height parameter in PTG. Conclusions. If a faster improvement is desired in the determined athletic performance parameters in a period of eight weeks in soccer, it may be recommended to prefer core and plyometric trainings in addition to branch training.   Keywords: Soccer, core, plyometrics, body composition, athletic performanc