2,757 research outputs found
On the dependence of the zeros of an entire function and its factorization
AbstractSome criteria for testing whether certain types of entire functions are prime or not are given in this paper. Most of the studies are based upon the distribution of the zeros of the function or its derivative
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Liquid biopsy genotyping in lung cancer: ready for clinical utility?
Liquid biopsy is a blood test that detects evidence of cancer cells or tumor DNA in the circulation. Despite complicated collection methods and the requirement for technique-dependent platforms, it has generated substantial interest due, in part, to its potential to detect driver oncogenes such as epidermal growth factor receptor (EGFR) mutants in lung cancer. This technology is advancing rapidly and is being incorporated into numerous EGFR tyrosine kinase inhibitor (EGFR-TKI) development programs. It appears ready for integration into clinical care. Recent studies have demonstrated that biological fluids such as saliva and urine can also be used for detecting EGFR mutant DNA through application other user-friendly techniques. This review focuses on the clinical application of liquid biopsies to lung cancer genotyping, including EGFR and other targets of genotype-directed therapy and compares multiple platforms used for liquid biopsy
A Simple Model for Cavity Enhanced Slow Lights in Vertical Cavity Surface Emission Lasers
We develop a simple model for the slow lights in Vertical Cavity Surface
Emission Lasers (VCSELs), with the combination of cavity and population
pulsation effects. The dependences of probe signal power, injection bias
current and wavelength detuning for the group delays are demonstrated
numerically and experimentally. Up to 65 ps group delays and up to 10 GHz
modulation frequency can be achieved in the room temperature at the wavelength
of 1.3 m. The most significant feature of our VCSEL device is that the
length of active region is only several m long. Based on the experimental
parameters of quantum dot VCSEL structures, we show that the resonance effect
of laser cavity plays a significant role to enhance the group delays
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