Microparticle Vaccines Against Toxoplasma gondii

Significant information indicates that future investigations on Toxoplasma vaccine development have to include adjuvants for enhancing protective immunity against Toxoplasma gondii. Especially, safe and effective adjuvants capable of fulfilling Th1‐dependent cell‐mediated immunity appear to be more likely to be allowed to use for anti Toxoplasma vaccine development. Recently, biodegradable and biocompatible polymers, such as poly (lactide‐co‐glycolide) (PLG) polymers, have been utilized as safe and efficacious adjuvants to encapsulate antigens for producing long‐term release microparticle‐based vaccines. PLG microencapsulation allows the sustained release of antigens and facilitates antigen uptake via antigen‐presenting cells (APCs) to favorably generate Th1 cell‐mediated immunity, which is required for the prevention of T. gondii infection. In our recent work, recombinant surface antigens (rSAGs), including rSAG1, rSAG2, and rSAG1/2, have been, respectively, encapsulated with the PLG polymer for production of PLG‐encapsulated rSAG1 (PLG‐rSAG1), PLG‐encapsulated rSAG2 (PLG‐rSAG2), or PLG‐encapsulated rSAG1/2 (PLG‐rSAG1/2) microparticles. This chapter describes adjuvant effect of PLG microparticles, controlled release of PLG microparticles, PLG microparticles‐immune system interaction, Toxoplasma SAG‐loaded PLG microparticles, protective immunity by Toxoplasma SAG‐loaded PLG microparticles, and future prospects. PLG microparticle vaccines would be advantageous for their application in the development of long‐lasting vaccines against T. gondii for future use in humans and animals

Affleck-Dine Baryogenesis, Split Supersymmetry, and Inflation

It is shown that, in the context of split supersymmetry, a simple model with a single complex scalar field can produce chaotic inflation and generate the observed amount of baryon asymmetry via the Affleck-Dine mechanism. While the inflaton quantum fluctuations give rise to curvature perturbation, we show that quantum fluctuations of the phase of the scalar field can produce baryonic isocurvature perturbation. Combining with constraints from WMAP data, all parameters in the model can be determined to within a narrow range.Comment: version accepted for publication in PR

Occlusion of acute distal brachial, proximal radial and ulnar arteries in a young thrower

SummaryAcute arterial occlusion, a rare condition in throwers, requires early detection and treatment for avoiding further complications. Thus far, no study has mentioned the occurrence of distal brachial, proximal radial, and ulnar artery occlusion in baseball players. An adolescent baseball pitcher presented with acute occlusion of the distal brachial, proximal radial, or ulnar artery. The patient complained of a cold sensation in the hand, wrist, and distal forearm. On physical examination, decreased surface skin temperature, and no radial pulse in the wrist suggested arterial occlusion. Emergency angiography validated the clinical suspicion, and identified the arteries and sites of vascular occlusion. Surgery was performed to alleviate the occlusions, thereby resolving the preoperative complaints and abnormal findings. Furthermore, postoperative magnetic resonance imaging of the shoulder and elbow joint was conducted to determine the causes of arterial occlusion. The patient resumed pitching 4 months postoperatively, and has remained active and symptom free. Magnetic resonance imaging examination revealed no vascular abnormalities or bony or soft tissue in the shoulder or elbow region. With early detection and treatment, a favorable prognosis can be achieved in baseball pitchers with acute upper extremity arterial occlusion so that their pitching career is not jeopardized

Achieving minimum-error discrimination of an arbitrary set of laser-light pulses

Laser light is widely used for communication and sensing applications, so the optimal discrimination of coherent states--the quantum states of light emitted by a laser--has immense practical importance. However, quantum mechanics imposes a fundamental limit on how well different coher- ent states can be distinguished, even with perfect detectors, and limits such discrimination to have a finite minimum probability of error. While conventional optical receivers lead to error rates well above this fundamental limit, Dolinar found an explicit receiver design involving optical feedback and photon counting that can achieve the minimum probability of error for discriminating any two given coherent states. The generalization of this construction to larger sets of coherent states has proven to be challenging, evidencing that there may be a limitation inherent to a linear-optics-based adaptive measurement strategy. In this Letter, we show how to achieve optimal discrimination of any set of coherent states using a resource-efficient quantum computer. Our construction leverages a recent result on discriminating multi-copy quantum hypotheses (arXiv:1201.6625) and properties of coherent states. Furthermore, our construction is reusable, composable, and applicable to designing quantum-limited processing of coherent-state signals to optimize any metric of choice. As illustrative examples, we analyze the performance of discriminating a ternary alphabet, and show how the quantum circuit of a receiver designed to discriminate a binary alphabet can be reused in discriminating multimode hypotheses. Finally, we show our result can be used to achieve the quantum limit on the rate of classical information transmission on a lossy optical channel, which is known to exceed the Shannon rate of all conventional optical receivers.Comment: 9 pages, 2 figures; v2 Minor correction

SIMP (Strongly Interacting Massive Particle) Search

We consider laboratory experiments that can detect stable, neutral strongly interacting massive particles (SIMPs). We explore the SIMP annihilation cross section from its minimum value (restricted by cosmological bounds) to the barn range, and vary the mass values from a GeV to a TeV. We also consider the prospects and problems of detecting such particles at the Tevatron.Comment: Latex. 7 pages, 1 eps figure. Proceedings to the 4th UCLA Symposium on Dark Matter DM2000, Marina del Rey, CA, USA, Feb. 23-25, 200

Lorentz violation and the proper-time method

In this paper, we apply the proper-time method to generate the Lorentz-violating Chern-Simons terms in the four-dimensional Yang-Mills and non-linearized gravity theories. It is shown that the coefficient of the induced Chern-Simons term is finite but regularization dependent.Comment: 11 pages, Revtex

Reconstruction of plasma density profiles by measuring spectra of radiation emitted from oscillating plasma dipoles

We suggest a new method for characterising non-uniform density distributions of plasma by measuring the spectra of radiation emitted from a localised plasma dipole oscillator excited by colliding electromagnetic pulses. The density distribution can be determined by scanning the collision point in space. Two-dimensional particle-in-cell simulations demonstrate the reconstruction of linear and nonlinear density profiles corresponding to laser-produced plasma. The method can be applied to a wide range of plasma, including fusion and low temperature plasmas. It overcomes many of the disadvantages of existing methods that only yield average densities along the path of probe pulses, such as interferometry and spectroscopy

A Comparative Study of Pentaquark Interpolating Currents

In a diquark-diquark-antiquark picture of pentaquarks, we use two interpolating currents to calculate the mass of the recently measured $\Xi^{--}$ state in the framework of QCD sum rules. We show that, even though yielding similar values for $m_{\Xi^{--}}$ (and close to the experimental value), these currents differ from each other in what concerns the strength of the pole, convergence of the OPE and sensitivity to the continuum threshold parameter.Comment: 19 pages, 8 figures, replaced version accepted for publication in Phys. Lett.

IMAGE-BASED MEASUREMENT AND BIOMECHANICAL ANALYSIS OF THE KNEE JOINT DURING FUNCTIONAL ACTIVITIES

A new approach based on the integration of medical image-based measurement techniques, infrared stereophotogrammetry and finite element modelling (FEM) was developed for comprehensive subject-specific biomechanical analyses of the knee joint during weight-bearing functional activities including cycling. The medical image-based methods include digitally reconstructed radiograph (DRR) based 3D fluoroscopy methods, and a new slice-to-volume registration method using FLASH MRI for the real-time measurement of the 3D kinematics of the knee in vivo. With the new approach, the soft tissue artefacts associated with skin marker-based stereophotogrammetry and their effects on the calculated biomechanical variables were also investigated