BlenDA: Domain Adaptive Object Detection through diffusion-based blending

Unsupervised domain adaptation (UDA) aims to transfer a model learned using labeled data from the source domain to unlabeled data in the target domain. To address the large domain gap issue between the source and target domains, we propose a novel regularization method for domain adaptive object detection, BlenDA, by generating the pseudo samples of the intermediate domains and their corresponding soft domain labels for adaptation training. The intermediate samples are generated by dynamically blending the source images with their corresponding translated images using an off-the-shelf pre-trained text-to-image diffusion model which takes the text label of the target domain as input and has demonstrated superior image-to-image translation quality. Based on experimental results from two adaptation benchmarks, our proposed approach can significantly enhance the performance of the state-of-the-art domain adaptive object detector, Adversarial Query Transformer (AQT). Particularly, in the Cityscapes to Foggy Cityscapes adaptation, we achieve an impressive 53.4% mAP on the Foggy Cityscapes dataset, surpassing the previous state-of-the-art by 1.5%. It is worth noting that our proposed method is also applicable to various paradigms of domain adaptive object detection. The code is available at:https://github.com/aiiu-lab/BlenDAComment: ICASSP(2024):2024 IEEE International Conference on Acoustics, Speech and Signal Processin

Effect of Topical Propolis on Wound Healing Process After Tonsillectomy: Randomized Controlled Study

Objectives The post-tonsillectomy pain and post-tonsillectomy hemorrhage are the two main problems after tonsillectomy. The aim of this study was to investigate the beneficial effects of water soluble ethanol extract propolis on post-tonsillectomy patient. Methods One hundred and thirty patients who underwent tonsillectomy or adenotonsillectomy were randomly divided into the control and propolis groups, each including 65 patients. The propolis group was applied with propolis orally immediately after surgery and by gargle. The pain scores were assessed on post-tonsillectomy 0, 1st, 2nd, 3rd, and 7th–10th day using a visual analogue scale score. Postoperative wound healing was evaluated by scoring pinkish membrane of tonsillar fossae on postoperative days 3 and 7–10. The incidence of post-tonsillectomy bleeding was examined in each group. Results Post-tonsillectomy pain was significantly less in propolis group compared to control group on postoperative days 3 and 7–10. Post-tonsillectomy hemorrhage was significantly less in the propolis group compared to the control group (P<0.05). The wound healing was significantly better in the propolis group compared to the control group on postoperative day 7–10 (P=0.002). Conclusion Applying the propolis to post-tonsillectomy wound showed beneficial effect of reducing postoperative pain, preventing hemorrhage, and accelerating of wound healing of tonsillar fossae

Antioxidant and Anti-Apoptotic Effect of Melatonin on the Vestibular Hair Cells of Rat Utricles

ObjectivesAminoglycosides are commonly used antibiotic agents, and they are known to generate free oxygen radicals within the inner ear and to cause vestibulo-cochlear toxicity and permanent damage to the sensory hair cells and neurons. Melatonin, a pineal secretory product, has the properties of being a powerful direct and indirect antioxidant. The aim of the present study was to prove the antioxidant effect of melatonin against gentamicin-induced ototoxicty.MethodsThe utricular maculae of Sprague-Dawley rats were prepared from postnatal day 2-4, and these maculae were were divided into 6 groups as follows: 1) control, 2) melatonin only, 3) gentamicin only, and 4), 5), and 6) gentamicin plus melatonin (10, 50, and 100 µM, respectively). To count the number of hair cells, 5 utricles from each group were stained with phalloidin-FITC on the 1st, 4th, and 7th days after drug administration. Reactive oxygen species (ROS) was assessed by using the fluorescent probe hydrofluorescent diacetate acetyl ester. The caspase-3 activity was also examined with using the fluorescent caspase-3 substrate and performing Western blotting.ResultsThe result of this study showed that gentamicin induced the loss of utricular hair cells, and this loss of hair cells was significantly attenuated by co-administration of melatonin. Melatonin reduced ROS production and caspase-3 activation in the gentamicin treated utricular hair cells.ConclusionOur findings conclusively reveal that melatonin has protective effects against gentamicin-induced hair cell loss in the utricles of rat by inhibiting both ROS production and caspase-3 activity

2021 Korean Society of Gastrointestinal Endoscopy Clinical Practice Guidelines for Endoscopic Sedation

Sedation can resolve anxiety and fear in patients undergoing endoscopy. The use of sedatives has increased in Korea. Appropriate sedation is a state in which the patient feels subjectively comfortable while maintaining the airway reflex for stable spontaneous breathing. The patient should maintain a state of consciousness to the extent that he or she can cooperate with the needs of the medical staff. Despite its benefits, endoscopic sedation has been associated with cardiopulmonary complications. Cardiopulmonary complications are usually temporary. Most patients recover without sequelae. However, they may progress to serious complications, such as cardiovascular collapse. Therefore, it is essential to screen high-risk patients before sedation and reduce complications by meticulous monitoring. Additionally, physicians should be familiar with the management of emergencies. The first Korean clinical practice guideline for endoscopic sedation was developed based on previous worldwide guidelines for endoscopic sedation using an adaptation process. The guideline consists of nine recommendations based on a critical review of currently available data and expert consensus when the guideline was drafted. These guidelines should provide clinicians, nurses, medical school students, and policy makers with information on how to perform endoscopic sedation with minimal risk

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals &lt;1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) 1-3 of esophageal squamous cell carcinoma (ESCC) in ethnic Chinese (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study, and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% CI 0.82-0.88; P=7.72x10−20) and rs1642764 at 17p13.1 (per-allele OR= 0.88, 95% CI 0.85-0.91; P=3.10x10−13). rs7447927 is a synonymous single nucleotide polymorphism (SNP) in TMEM173 and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR=1.33, 95% CI 1.22-1.46; P=1.99x10−10). Our joint analysis identified new ESCC susceptibility loci overall as well as a new locus unique to the ESCC high risk Taihang Mountain region

USING MULTIMODAL IMAGING TO EXAMINE CLINICAL AND COGNITIVE CORRELATES OF MILD COGNITIVE IMPAIRMENT AND ALZHEIMER’S DISEASE

Mild cognitive impairment (MCI) may interact with depression to mediate the risk of developing Alzheimer’s disease (AD). Investigating the relationship between depression-related and AD-associated pathological changes such as beta-amyloid (Aβ), tau, and hippocampal volume loss may help to explain the mechanistic links between depression and the cognitive and functional impairment underlying AD. We employed different neuroimaging techniques, including positron emission tomography (PET) and magnetic resonance imaging, to investigate several in-vivo markers of AD pathology, allowing us to examine their associations with clinical (e.g. symptoms of depression) and cognitive correlates of MCI and AD. The thesis covers five themes. The first theme seeks to explore the relationship between a lifetime history of depression and cortical Aβ burden using PET. The second theme investigates the association between late-life depressive symptoms and cortical Aβ, also using PET. The third theme examines hippocampal volume atrophy to observe how depressive symptoms and progressive hippocampal volume loss mediate the conversion process from MCI to dementia. The fourth theme focuses on the longitudinal and structural trajectories of MCI patients with suspected non-Alzheimer’ disease in order to examine how their pathological and cognitive profiles differ from other MCI groups. The final theme seeks to investigate the link between usage of the psychoactive agent benzodiazepine and cerebral Aβ levels using participants’ longitudinal cognitive profile and PET. Overall, a history of depression appears to be more strongly associated with increased Aβ burden than late-life depressive symptoms. However, late-life depression, in conjunction with hippocampal atrophy, may accelerate the conversion process to AD. Furthermore, this thesis emphasizes that Aβ level is not required to promote cognitive and functional deterioration; thus Aβ levels only partially explain mechanisms underlying AD pathogenesis. Lastly, this thesis elucidates the importance of early and preventative interventions to reduce the future incidence of AD.Ph.D