Orbital stability of periodic traveling waves to some coupled BBM equations

In this work, we show some results concerning the orbital stability of dnoidal wave solutions to some Benjamin-Bona-Mahony equations (BBM equations henceforth). First, by the standard argument, we prove the existence of a smooth curve of positive traveling wave solutions of dnoidal type. Then, we show that this type of solutions are orbitally stable by perturbations with the same period L. The major tools to obtain these results are the Grillaks, Shatah and Strauss' general theory in the periodic case. The results in the present paper extend some previous stability results for the BBM equations

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone

Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models

NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity

Abstract Background N-acetyltransferase 10 (NAT10) is a histone acetyltransferase which is involved in a wide range of cellular processes. Recent evidences indicate that NAT10 is involved in the development of human cancers. Previous study showed that NAT10 acetylates the tumor suppressor p53 and regulates p53 activation. As Tp53 gene is frequently mutated in hepatocellular carcinoma (HCC) and associates with the occurrence and development of HCC, the relationship between NAT10 and HCC was investigated in this study. Methods Immunohistochemistry (IHC) and western blot analysis were performed to evaluate the NAT10 expression in HCC. Immunoprecipitation experiments were performed to verify the interaction of NAT10 with mutant p53 and Mdm2. RNA interference and Western blot were applied to determine the effect of NAT10 on mutant p53. Cell growth curve was used to examine the effect of NAT10 on HCC cell proliferation. Results NAT10 was upregulated in HCC and increased NAT10 expression was correlated with poor overall survival of the patients. NAT10 protein levels were significantly correlated with p53 levels in human HCC tissues. Furthermore, NAT10 increased mutant p53 levels by counteracting Mdm2 action in HCC cells and promoted proliferation in cells carrying p53 mutation. Conclusion Increased NAT10 expression levels are associated with shortened patient survival and correlated with mutant p53 levels. NAT10 upregulates mutant p53 level and might enhance its tumorigenic activity. Hence, we propose that NAT10 is a potential prognostic and therapeutic candidate for p53-mutated HCC