366 research outputs found
Searching for Heavier Higgs Boson via Di-Higgs Production at LHC Run-2
The LHC discovery of a light Higgs particle (125GeV) opens up new
prospect for searching heavier Higgs boson(s) at the LHC Run-2, which will
unambiguously point to new physics beyond the standard model (SM). We study the
detection of a heavier neutral Higgs boson via di-Higgs production
channel at the LHC (14TeV), . This
directly probes the cubic Higgs interaction, which exists in most
extensions of the SM Higgs sector. For the decay products of final states
, we include both pure leptonic mode and semi-leptonic mode .
We analyze signals and backgrounds by performing fast detector simulation for
the full processes and , over the mass range
GeV. For generic two-Higgs-doublet models (2HDM), we present the
discovery reach of the heavier Higgs boson at the LHC Run-2, and compare it
with the current Higgs global fit of the 2HDM parameter space.Comment: Phys.Lett.B Final Version. 16pp (9 Figs + 4 Tables). Only minor
refinements, references adde
GeV Scale Asymmetric Dark Matter from Mirror Universe: Direct Detection and LHC Signatures
Mirror universe is a fundamental way to restore parity symmetry in weak
interactions. It naturally provides the lightest mirror nucleon as a unique
GeV-scale asymmetric dark matter particle candidate. We conjecture that the
mirror parity is respected by the fundamental interaction Lagrangian, and its
possible soft breaking arises only from non-interaction terms in the
gauge-singlet sector. We realize the spontaneous mirror parity violation by
minimizing the vacuum Higgs potential, and derive the corresponding Higgs
spectrum. We demonstrate that the common origin of CP violation in the visible
and mirror neutrino seesaws can generate the right amount of matter and mirror
dark matter via leptogenesis. We analyze the direct detections of GeV-scale
mirror dark matter by TEXONO and CDEX experiments. We further study the
predicted distinctive Higgs signatures at the LHC.Comment: 16pp. Plenary talk presented by HJH at the International Symposium on
Cosmology and Particle Astrophysics (CosPA2011). To appear in the conference
proceedings of IJMP. Minor refinement
High Dose ESAs Are Associated with High iPTH Levels in Hemodialysis Patients with End-Stage Kidney Disease: A Retrospective Analysis
Objective: Anemia and secondary hyperparathyroidism are the two most common complications associated with chronic kidney disease (CKD). Erythropoiesis-stimulating agents (ESAs) are widely used in the management of anemia in hemodialysis patients. A reverse correlation has been established between hyperparathyroidism and hemoglobin levels. The aim of this retrospective study is to evaluate the relationship of high dose ESAs and hyperparathyroidism in hemodialysis patients with anemia. Methods: A total of 240 uremic patients maintained on regular hemodialysis were enrolled into this study. Among them, 142 patients were treated with Epiao® (epoetin-alfa) and 98 patients were treated with Recormon® (epoetin-beta). The target hemoglobin concentration was 110-130 g/L. Laboratory measurements including hemoglobin, calcium, phosphorus, albumin, intact-parathyroid hormone (iPTH), serum ferritin and transferrin saturation were collected. Results: Hemoglobin concentration increased as iPTH level decreased by stratification. However, no significant association between anemia and calcium or phosphorus level was found. Patients with iPTH levels within 150-300 pg/mL had the highest levels of hemoglobin, serum ferritin and transferrin saturation. Patients treated with Recormon and Epiao had similar hemoglobin concentrations. However, the dose of Recormon for anemia treatment was significantly less than that the dose of Epiao (P<0.05). The level of iPTH in the Recormon group was significantly lower than in the Epiao group. In patients with hemoglobin levels between 110-130 g/L (P<0.05), iPTH level was found to be significantly lower in patients treated with lower doses of ESAs than in patients treated with higher doses of ESAs, no matter which ESA was used (Recormon or Epiao, P<0.05). Conclusions: The dose of ESAs might be positively associated with iPTH level, suggesting that a reasonable hemoglobin target can be achieved by using the lowest possible ESA dose
Simultaneous Structural Identification of Natural Products in Fractions of Crude Extract of the Rare Endangered Plant Anoectochilus roxburghii Using 1H NMR/RRLC-MS Parallel Dynamic Spectroscopy
Nuclear magnetic resonance/liquid chromatography-mass spectroscopy parallel dynamic spectroscopy (NMR/LC-MS PDS) is a method aimed at the simultaneous structural identification of natural products in complex mixtures. In this study, the method is illustrated with respect to 1H NMR and rapid resolution liquid chromatography-mass spectroscopy (RRLC-MS) data, acquired from the crude extract of Anoectochilus roxburghii, which was separated into a series of fractions with the concentration of constituent dynamic variation using reversed-phase preparative chromatography. Through fraction ranges and intensity changing profiles in 1H NMR/RRLC–MS PDS spectrum, 1H NMR and the extracted ion chromatogram (XIC) signals deriving from the same individual constituent, were correlated due to the signal amplitude co-variation resulting from the concentration variation of constituents in a series of incompletely separated fractions. 1H NMR/RRLC-MS PDS was then successfully used to identify three types of natural products, including eight flavonoids, four organic acids and p-hydroxybenzaldehyde, five of which have not previously been reported in Anoectochilus roxburghii. In addition, two groups of co-eluted compounds were successfully identified. The results prove that this approach should be of benefit in the unequivocal structural determination of a variety of classes of compounds from extremely complex mixtures, such as herbs and biological samples, which will lead to improved efficiency in the identification of new potential lead compounds
Seven common errors in finding exact solutions of nonlinear differential equations
We analyze the common errors of the recent papers in which the solitary wave
solutions of nonlinear differential equations are presented. Seven common
errors are formulated and classified. These errors are illustrated by using
multiple examples of the common errors from the recent publications. We show
that many popular methods in finding of the exact solutions are equivalent each
other. We demonstrate that some authors look for the solitary wave solutions of
nonlinear ordinary differential equations and do not take into account the well
- known general solutions of these equations. We illustrate several cases when
authors present some functions for describing solutions but do not use
arbitrary constants. As this fact takes place the redundant solutions of
differential equations are found. A few examples of incorrect solutions by some
authors are presented. Several other errors in finding the exact solutions of
nonlinear differential equations are also discussed.Comment: 42 page
Craniometrics reveal "two layers" of prehistoric human dispersal in eastern Eurasia
This cranio-morphometric study emphasizes a "two-layer model" for eastern Eurasian anatomically modern human (AMH) populations, based on large datasets of 89 population samples including findings directly from ancient archaeological contexts. Results suggest that an initial "first layer" of AMH had related closely to ancestral Andaman, Australian, Papuan, and Jomon groups who likely entered this region via the Southeast Asian landmass, prior to 65–50 kya. A later "second layer" shared strong cranial affinities with Siberians, implying a Northeast Asian source, evidenced by 9 kya in central China and then followed by expansions of descendant groups into Southeast Asia after 4 kya. These two populations shared limited initial exchange, and the second layer grew at a faster rate and in greater numbers, linked with contexts of farming that may have supported increased population densities. Clear dichotomization between the two layers implies a temporally deep divergence of distinct migration routes for AMH through both southern and northern Eurasia
Hydroxy-α-sanshool isolated from Zanthoxylum bungeanum Maxim. has antidiabetic effects on high-fat-fed and streptozotocin-treated mice via increasing glycogen synthesis by regulation of PI3K/Akt/GSK-3β/GS signaling
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia. The fruits of Zanthoxylum bungeanum Maxim. is a common spice and herbal medicine in China, and hydroxy-α-sanshool (HAS) is the most abundant amide in Z. bungeanum and reported to have significant hypoglycemic effects. The purpose of this study was to evaluate the ameliorative effects of HAS on T2DM and the potential mechanisms responsible for those effects. An acute toxicity test revealed the median lethal dose (LD50) of HAS is 73 mg/kg. C57BL/6 J mice were fed a high-fat diet and given an intraperitoneal injection of streptozotocin (STZ) to induce T2DM in mice to evaluate the hypoglycemic effects of HAS. The results showed that HAS significantly reduced fasting blood glucose, reduced pathological changes in the liver and pancreas, and increased liver glycogen content. In addition, glucosamine (GlcN)-induced HepG2 cells were used to establish an insulin resistance cell model and explore the molecular mechanisms of HAS activity. The results demonstrated that HAS significantly increases glucose uptake and glycogen synthesis in HepG2 cells and activates the PI3K/Akt pathway in GlcN-induced cells, as well as increases GSK-3β phosphorylation, suppresses phosphorylation of glycogen synthase (GS) and increases glycogen synthesis in liver cells. Furthermore, these effects of HAS were blocked by the PI3K inhibitor LY294002. The results of our study suggest that HAS reduces hepatic insulin resistance and increases hepatic glycogen synthesis by activating the PI3K/Akt/GSK-3β/GS signaling pathway
The CDEX-1 1 kg Point-Contact Germanium Detector for Low Mass Dark Matter Searches
The CDEX Collaboration has been established for direct detection of light
dark matter particles, using ultra-low energy threshold p-type point-contact
germanium detectors, in China JinPing underground Laboratory (CJPL). The first
1 kg point-contact germanium detector with a sub-keV energy threshold has been
tested in a passive shielding system located in CJPL. The outputs from both the
point-contact p+ electrode and the outside n+ electrode make it possible to
scan the lower energy range of less than 1 keV and at the same time to detect
the higher energy range up to 3 MeV. The outputs from both p+ and n+ electrode
may also provide a more powerful method for signal discrimination for dark
matter experiment. Some key parameters, including energy resolution, dead time,
decay times of internal X-rays, and system stability, have been tested and
measured. The results show that the 1 kg point-contact germanium detector,
together with its shielding system and electronics, can run smoothly with good
performances. This detector system will be deployed for dark matter search
experiments.Comment: 6 pages, 8 figure
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