1,720 research outputs found
An hourglass model for the flare of HST-1 in M87
To explain the multi-wavelength light curves (from radio to X-ray) of HST-1
in the M87 jet, we propose an hourglass model that is a modified two-zone
system of Tavecchio & Ghisellini (hereafter TG08): a slow hourglass-shaped or
Laval nozzle-shaped layer connected by two revolving exponential surfaces
surrounding a fast spine, through which plasma blobs flow. Based on the
conservation of magnetic flux, the magnetic field changes along the axis of the
hourglass. We adopt the result of TG08---the high-energy emission from GeV to
TeV can be produced through inverse Compton by the two-zone system, and the
photons from radio to X-ray are mainly radiated by the fast inner zone system.
Here, we only discuss the light curves of the fast inner blob from radio to
X-ray. When a compressible blob travels down the axis of the first bulb in the
hourglass, because of magnetic flux conservation, its cross section experiences
an adiabatic compression process, which results in particle acceleration and
the brightening of HST-1. When the blob moves into the second bulb of the
hourglass, because of magnetic flux conservation, the dimming of the knot
occurs along with an adiabatic expansion of its cross section. A similar broken
exponential function could fit the TeV peaks in M87, which may imply a
correlation between the TeV flares of M87 and the light curves from radio to
X-ray in HST-1. The Very Large Array (VLA) 22 GHz radio light curve of HST-1
verifies our prediction based on the model fit to the main peak of the VLA 15
GHz radio light curve.Comment: 14 pages, 2 figures, accepted for publication in A
catena-Poly[[bisÂ(pyridine-ÎşN)nickel(II)]-Îź-oxalato-Îş4 O 1,O 2:O 1â˛,O 2â˛]
The title compound, [Ni(C2O4)(C5H5N)2]n, was synthesized under hydroÂ(solvo)thermal conditions. The NiII atom, lying on a twofold rotation axis, has an octaÂhedral coordination geometry involving two N atoms from two pyridine ligands and four O atoms from two oxalate ligands. The Ni atoms are connected by the tetraÂdentate bridging oxalate ligands into a one-dimensional zigzag chain
Observation of Majorana fermions with spin selective Andreev reflection in the vortex of topological superconductor
Majorana fermion (MF) whose antiparticle is itself has been predicted in
condensed matter systems. Signatures of the MFs have been reported as zero
energy modes in various systems. More definitive evidences are highly desired
to verify the existence of the MF. Very recently, theory has predicted MFs to
induce spin selective Andreev reflection (SSAR), a novel magnetic property
which can be used to detect the MFs. Here we report the first observation of
the SSAR from MFs inside vortices in Bi2Te3/NbSe2 hetero-structure, in which
topological superconductivity was previously established. By using
spin-polarized scanning tunneling microscopy/spectroscopy (STM/STS), we show
that the zero-bias peak of the tunneling differential conductance at the vortex
center is substantially higher when the tip polarization and the external
magnetic field are parallel than anti-parallel to each other. Such strong spin
dependence of the tunneling is absent away from the vortex center, or in a
conventional superconductor. The observed spin dependent tunneling effect is a
direct evidence for the SSAR from MFs, fully consistent with theoretical
analyses. Our work provides definitive evidences of MFs and will stimulate the
MFs research on their novel physical properties, hence a step towards their
statistics and application in quantum computing.Comment: 4 figures 15 page
Two new lignan-iridoid glucoside diesters from the leaves of Vaccinium bracteatum and their relative and absolute configuration determination by DFT NMR and TDDFT-ECD calculation
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Differential expression of microRNAs in GH-secreting pituitary adenomas
<p>Abstract</p> <p>Background</p> <p>The purpose of this study was to (1) identify specific miRNAs in growth hormones (GH)-secreting pituitary adenomas; (2) determine the relationship between the expression of these miRNAs and tumor size, somatostatin analogs treatment, and responsiveness to somatostatin analogs (SSA).</p> <p>Methods</p> <p>Fifteen GH-secreting adenomas patients were treated with lanreotide for 4 months before surgery. Patients with 50% reduction of GH secretion by lanreotide were considered as SSA responders, while patients with less than 50% of GH reduction were considered as SSA nonresponders. We analyzed the miRNAs in 21 GH-secreting pituitary adenomas and 6 normal pituitaries by miRCURY⢠LNA array and some differentially expressed miRNAs were validated by quantitative real-time PCR.</p> <p>Results</p> <p>Fifty-two miRNAs were differentially expressed between GH-secreting pituitary adenomas and normal pituitaries. Differential expression of 9 miRNAs was observed between micro- and macro-adenomas. Thirteen miRNAs were differentially expressed between tumor samples from lanreotide-treated patients and those from lanreotide-untreated patients. Seven miRNAs were differentially expressed between SSA responders or GH nonresponders. Several identified miRNAs may be involved in cell proliferation, apoptosis, cancer development and progression.</p> <p>Conclusions</p> <p>Our results indicate that altered miRNAs expression is involved in GH-secreting pituitary adenomas transformation, which will shed light on the mechanisms for the treatment of acromegaly by SSA. Identification and characterization of the targets of altered miRNAs genes may elucidate molecular mechanisms involved in the pathogenesis of pituitary adenoma.</p
Systemic Review and Meta-Analysis of the Clinical Efficacy and Adverse Effects of Zhengqing Fengtongning Combined with Methotrexate in Rheumatoid Arthritis
Transcriptional regulation of macrophages in heart failure
Adverse cardiac remodeling after acute myocardial infarction is the most important pathological mechanism of heart failure and remains a major problem in clinical practice. Cardiac macrophages, derived from tissue resident macrophages and circulating monocyte, undergo significant phenotypic and functional changes following cardiac injury and play crucial roles in inflammatory response and tissue repair response. Currently, numerous studies indicate that epigenetic regulatory factors and transcription factors can regulate the transcription of inflammatory and reparative genes and timely conversion of inflammatory macrophages into reparative macrophages and then alleviate cardiac remodeling. Accordingly, targeting transcriptional regulation of macrophages may be a promising option for heart failure treatment. In this review, we not only summarize the origin and function of cardiac macrophages, but more importantly, describe the transcriptional regulation of macrophages in heart failure, aiming to provide a potential therapeutic target for heart failure
Enzymatic Sensor for Sterigmatocystin Detection and Feasibility Investigation of Predicting Aflatoxin B1 Contamination by Indicator
A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III
We established a method on measuring the \dzdzb mixing parameter for
BESIII experiment at the BEPCII collider. In this method, the doubly
tagged events, with one decays to
CP-eigenstates and the other decays semileptonically, are used to
reconstruct the signals. Since this analysis requires good separation,
a likelihood approach, which combines the , time of flight and the
electromagnetic shower detectors information, is used for particle
identification. We estimate the sensitivity of the measurement of to be
0.007 based on a fully simulated MC sample.Comment: 6 pages, 7 figure
Divergent evolutionary rates of primate brain regions as revealed by genomics and transcriptomics
Although the primate brain contains numerous functionally distinct structures that have experienced diverse genetic changes during the course of evolution and development, these changes remain to be explored in detail. Here we utilize two classic metrics from evolutionary biology, the evolutionary rate index (ERI) and the transcriptome age index (TAI), to investigate the evolutionary alterations that have occurred in each area and developmental stage of the primate brain. We observed a higher evolutionary rate for those genes expressed in the non-cortical areas during primate evolution, particularly in human, with the highest rate of evolution being exhibited at brain developmental stages between late infancy and early childhood. Further, the transcriptome age of the non-cortical areas was lower than that of the cerebral cortex, with the youngest age apparent at brain developmental stages between late infancy and early childhood. Our exploration of the evolutionary patterns manifest in each brain area and developmental stage provides important reference points for further research into primate brain evolution
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