Search for Axionlike and Scalar Particles with the NA64 Experiment

We carried out a model-independent search for light scalar (s) and pseudoscalar axionlike (a) particles that couple to two photons by using the high-energy CERN SPS H4 electron beam. The new particles, if they exist, could be produced through the Primakoff effect in interactions of hard bremsstrahlung photons generated by 100 GeV electrons in the NA64 active dump with virtual photons provided by the nuclei of the dump. The a(s) would penetrate the downstream HCAL module, serving as shielding, and would be observed either through their $a(s)\to\gamma \gamma$ decay in the rest of the HCAL detector or as events with large missing energy if the a(s) decays downstream of the HCAL. This method allows for the probing the a(s) parameter space, including those from generic axion models, inaccessible to previous experiments. No evidence of such processes has been found from the analysis of the data corresponding to $2.84\times10^{11}$ electrons on target allowing to set new limits on the $a(s)\gamma\gamma$-coupling strength for a(s) masses below 55 MeV.Comment: This publication is dedicated to the memory of our colleague Danila Tlisov. 7 pages, 5 figures, revised version accepted for publication in Phys. Rev. Let

Loss of heterozygosity at 7p in Wilms' tumour development

Chromosome 7p alterations have been implicated in the development of Wilms' tumour (WT) by previous studies of tumour cytogenetics, and by our analysis of a constitutional translocation (t(1;7)(q42;p15)) in a child with WT and radial aplasia. We therefore used polymorphic microsatellite markers on 7p for a loss of heterozygosity (LOH) study, and found LOH in seven out of 77 informative WTs (9%). The common region of LOH was 7p15–7p22, which contains the region disrupted by the t(1;7) breakpoint. Four WTs with 7p LOH had other genetic changes; a germline WT1 mutation with 11p LOH, LOH at 11p, LOH at 16q, and loss of imprinting of IGF2. Analysis of three tumour-associated lesions from 7p LOH cases revealed a cystic nephroma-like area also having 7p LOH. However, a nephrogenic rest and a contralateral WT from the two other cases showed no 7p LOH. No particular clinical phenotype was associated with the WTs which showed 7p LOH. The frequency and pattern of 7p LOH demonstrated in our studies indicate the presence of a tumour suppressor gene at 7p involved in the development of Wilms' tumour. © 2000 Cancer Research Campaig

Search for Axionlike and Scalar Particles with the NA64 Experiment

We carried out a model-independent search for light scalar (s) and pseudoscalar axionlike (a) particles that couple to two photons by using the high-energy CERN SPS H4 electron beam. The new particles, if they exist, could be produced through the Primakoff effect in interactions of hard bremsstrahlung photons generated by 100 GeV electrons in the NA64 active dump with virtual photons provided by the nuclei of the dump. The a(s) would penetrate the downstream HCAL module, serving as a shield, and would be observed either through their a(s)→γγ decay in the rest of the HCAL detector, or as events with a large missing energy if the a(s) decays downstream of the HCAL. This method allows for the probing of the a(s) parameter space, including those from generic axion models, inaccessible to previous experiments. No evidence of such processes has been found from the analysis of the data corresponding to 2.84×10^{11} electrons on target, allowing us to set new limits on the a(s)γγ-coupling strength for a(s) masses below 55 MeV

Improved exclusion limit for light dark matter from e+e- annihilation in NA64

The current most stringent constraints for the existence of sub-GeV dark matter coupling to Standard Model via a massive vector boson A′ were set by the NA64 experiment for the mass region mA′≲250 MeV, by analyzing data from the interaction of 2.84×1011 100-GeV electrons with an active thick target and searching for missing-energy events. In this work, by including A′ production via secondary positron annihilation with atomic electrons, we extend these limits in the 200-300 MeV region by almost an order of magnitude, touching for the first time the dark matter relic density constrained parameter combinations. Our new results demonstrate the power of the resonant annihilation process in missing energy dark-matter searches, paving the road to future dedicated e+ beam efforts

Search for pseudoscalar bosons decaying into e+e- pairs in the NA64 experiment at the CERN SPS

We report the results of a search for a light pseudoscalar particle a that couples to electrons and decays to e+e- performed using the high-energy CERN SPS H4 electron beam. If such light pseudoscalar exists, it could explain the ATOMKI anomaly (an excess of e+e- pairs in the nuclear transitions of Be8 and He4 nuclei at the invariant mass ≃17 MeV observed by the experiment at the 5 MV Van de Graaff accelerator at ATOMKI, Hungary). We used the NA64 data collected in the "visible mode"configuration with a total statistics corresponding to 8.4×1010 electrons on target (EOT) in 2017 and 2018. In order to increase sensitivity to small coupling parameter ϵ we also used the data collected in 2016-2018 in the "invisible mode"configuration of NA64 with a total statistics corresponding to 2.84×1011 EOT. The background and efficiency estimates for these two configurations were retained from our previous analyses searching for light vector bosons and axionlike particles (ALP) (the latter were assumed to couple predominantly to γ). In this work we recalculate the signal yields, which are different due to different cross section and lifetime of a pseudoscalar particle a, and perform a new statistical analysis. As a result, the region of the two dimensional parameter space ma-ϵ in the mass range from 1 to 17.1 MeV is excluded. At the mass of the central value of the ATOMKI anomaly (the first result obtained on the beryllium nucleus, 16.7 MeV) the values of ϵ in the range 2.1×10-4<ϵ<3.2×10-4 are excluded

Measurement of the intrinsic hadronic contamination in the NA64−e high-e+/e- purity beam at CERN

We present the measurement of the intrinsic hadronic contamination at the CERN SPS H4 beamline configured to transport electrons and positrons at 100 GeV/c. The analysis, performed using data collected by the NA64-e experiment in 2022, is based on calorimetric measurements, exploiting the different interaction mechanisms of electrons and hadrons in the NA64 detector. We determined the contamination by comparing the results obtained using the nominal electron/positron beamline configuration with those from a dedicated setup, in which only hadrons impinged on the detector. We also obtained an estimate of the relative protons, anti-protons and pions yield by exploiting the different absorption probabilities of these particles in matter. We cross-checked our results with a dedicated Monte Carlo simulation for the hadron production at the primary T2 target, finding a good agreement with the experimental measurements

Genome-Wide Association Study of Treatment Refractory Schizophrenia in Han Chinese

We report the first genome-wide association study of a joint analysis using 795 Han Chinese individuals with treatment-refractory schizophrenia (TRS) and 806 controls. Three loci showed suggestive significant association with TRS were identified. These loci include: rs10218843 (P = 3.04×10−7) and rs11265461 (P = 1.94×10−7) are adjacent to signaling lymphocytic activation molecule family member 1 (SLAMF1); rs4699030 (P = 1.94×10−6) and rs230529 (P = 1.74×10−7) are located in the gene nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1); and rs13049286 (P = 3.05×10−5) and rs3827219 (P = 1.66×10−5) fall in receptor-interacting serine/threonine-protein kinase 4 (RIPK4). One isolated single nucleotide polymorphism (SNP), rs739617 (P = 3.87×10−5) was also identified to be associated with TRS. The -94delATTG allele (rs28362691) located in the promoter region of NFKB1 was identified by resequencing and was found to associate with TRS (P = 4.85×10−6). The promoter assay demonstrated that the -94delATTG allele had a significant lower promoter activity than the -94insATTG allele in the SH-SY5Y cells. This study suggests that rs28362691 in NFKB1 might be involved in the development of TRS

Search for a Hypothetical 16.7 MeV Gauge Boson and Dark Photons in the NA64 Experiment at CERN

We report the first results on a direct search for a new 16.7 MeV boson ( X ) which could explain the anomalous excess of e + e − pairs observed in the excited 8 Be ∗ nucleus decays. Because of its coupling to electrons, the X could be produced in the bremsstrahlung reaction e − Z → e − Z X by a 100 GeV e − beam incident on an active target in the NA64 experiment at the CERN Super Proton Synchrotron and observed through the subsequent decay into a e + e − pair. With 5.4 × 10 10 electrons on target, no evidence for such decays was found, allowing us to set first limits on the X − e − coupling in the range 1.3 × 10 − 4 ≲ ε e ≲ 4.2 × 10 − 4 excluding part of the allowed parameter space. We also set new bounds on the mixing strength of photons with dark photons ( A ′ ) from nonobservation of the decay A ′ → e + e − of the bremsstrahlung A ′ with a mass ≲ 23     Me