Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus <i>Acremonium</i> sp. F9A015

Two new benzophenones, acredinones A (<b>1</b>) and B (<b>2</b>), were isolated from a marine-sponge-associated <i>Acremonium</i> sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of <b>1</b> was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (<b>1</b>) and B (<b>2</b>) inhibited the outward K⁺ currents of the insulin secreting cell line INS-1 with IC₅₀ values of 0.59 and 1.0 μM, respectively

Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus <i>Acremonium</i> sp. F9A015

Two new benzophenones, acredinones A (<b>1</b>) and B (<b>2</b>), were isolated from a marine-sponge-associated <i>Acremonium</i> sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of <b>1</b> was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (<b>1</b>) and B (<b>2</b>) inhibited the outward K⁺ currents of the insulin secreting cell line INS-1 with IC₅₀ values of 0.59 and 1.0 μM, respectively