Acredinones
A and B, Voltage-Dependent Potassium Channel
Inhibitors from the Sponge-Derived Fungus <i>Acremonium</i> sp. F9A015
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Abstract
Two new benzophenones, acredinones
A (<b>1</b>) and B (<b>2</b>), were isolated from a marine-sponge-associated <i>Acremonium</i> sp. fungus. Their chemical structures were elucidated
on the interpretation of spectroscopic data. The structure of <b>1</b> was confirmed by palladium-catalyzed hydrogenation, followed
by spectroscopic data analysis. Acredinones A (<b>1</b>) and
B (<b>2</b>) inhibited the outward K<sup>+</sup> currents of
the insulin secreting cell line INS-1 with IC<sub>50</sub> values
of 0.59 and 1.0 μM, respectively
