10 research outputs found
Sulfides, sulfones, and sulfoxides of the furan-2(5H)-one series. synthesis and structure
A number of 4- and 5-R-sulfanylfuran-2(5H)-one derivatives were synthesized, and their oxidation with various reagents was studied. The corresponding sulfones were obtained using hydrogen peroxide in acetic acid. 4-R-sulfanyl derivatives were selectively oxidized to sulfoxides with m-chloroperoxybenzoic acid. The molecular and crystal structures of some new sulfones and sulfoxides were determined by X-ray analysis. Β© 2014 Pleiades Publishing, Ltd
ΠΠ£ΠΠ¬Π’ΠΠΠΠΠ£Π‘ΠΠΠ Π‘ΠΠΠΠΠΠ‘Π’ΠΠΠΠ ΠΠΠΠΠΠ Π¨Π’ΠΠΠΠΠ STREPTOCOCCUS PNEUMONIAE, ΠΠ«ΠΠΠΠΠΠΠ«Π₯ Π£ ΠΠΠ¦ΠΠΠΠ’ΠΠ ΠΠΠΠΠΠΠΠ ΠΠΠΠ ΠΠ‘Π’Π Π‘ ΠΠΠΠΠΠΠ¬ΠΠΠ§ΠΠ«ΠΠ ΠΠΠΠΠΠΠΠΠ―ΠΠ
Comuunity-acquired pneumonias in aged patients is the significant epidemiology problem for the public health of almost all the countries. Even more important the problem of microbiological monitoring and epidemiology surveillance for the S. pneumoniae strains as one of the ubiquitous pathogens causing as the community-acquired pneumonias as well the other infections of respiratory tract, what defines their different epidemiological meaning.Multilocus sequence typing is the perspective method of molecular epidemiological surveillance allowing to define the epidemiologically dangerous clones of the ubiquitous microorganisms as Streptococcus pneumomiae. The aim of our research was to conduct the multilocus sequence typing of pneumococci strains isolated in patients with community acquired pneumonias, bronchitis in aged patients.Materials and methods. There were taken 14 strains of S. pneumoniae, isolated in patients with community-acquired pneumonias (seven of them were multiresistant), eight strains were isolated from patients with the chronical onstructive lung diseases and four strains from carriers. Multilocus sequence typing was conduected according to method to M.C. Enright and B.G. Spratt (1998).Results. The strains, isolated in all populations were the related isolates of the species S. pneumoniae, the most of them had the unique genotype defining the sequence type for every strain. There were 6 strains of Taiwan 19F-14 genotype from 14 strains isolated in aged patients with community-acquired pneumonia. Among strains isolated from carriers there were prevailing the strai of R6 genotype.Conclusion. Multilocus sequence typing allows to identify the new genotypes and to prognose the appearing of epidemiologically dangerous strains with new peculiarities.ΠΠ½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΡΠ΅ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠΈ Ρ Π»ΠΈΡ ΠΏΠΎΠΆΠΈΠ»ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΡΠ²Π»ΡΡΡΡΡ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠΎΠΉ Π΄Π»Ρ Π·Π΄ΡΠ°Π²ΠΎΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π²ΡΠ΅Ρ
ΡΡΡΠ°Π½. ΠΡΠΎΠ±Π΅Π½Π½ΠΎ Π°ΠΊΡΡΠ°Π»ΡΠ½Π° ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ° ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΠΈ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π½Π°Π΄Π·ΠΎΡΠ° Π·Π° ΡΡΠ°ΠΌΠΌΠ°ΠΌΠΈ Streptococcuspneumoniae, ΠΊΠ°ΠΊ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· ΡΠ±ΠΈΠΊΠ²ΠΈΡΠ°ΡΠ½ΡΡ
Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ, Π²ΡΠ·ΡΠ²Π°ΡΡΠΈΡ
Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΡΠ΅ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠΈ ΠΈ Π΄ΡΡΠ³ΠΈΠ΅ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ, ΡΡΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ ΠΈΡ
ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡΡ.ΠΡΠ»ΡΡΠΈΠ»ΠΎΠΊΡΡΠ½ΠΎΠ΅ ΡΠΈΠΊΠ²Π΅Π½ΡΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ β ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π°, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠ΅Π³ΠΎ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°ΡΡ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈ ΠΎΠΏΠ°ΡΠ½ΡΠ΅ ΠΊΠ»ΠΎΠ½Ρ S. pneumoniae. Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΌΡΠ»ΡΡΠΈΠ»ΠΎΠΊΡΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ²Π΅Π½ΡΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ°ΠΌΠΌΠΎΠ² ΠΏΠ½Π΅Π²ΠΌΠΎΠΊΠΎΠΊΠΊΠ°, Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΡΠΌΠΈ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΡΠΌΠΈ, Π±ΡΠΎΠ½Ρ
ΠΈΡΠ°ΠΌΠΈ ΠΈ Ρ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ ΠΏΠΎΠΆΠΈΠ»ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠ»ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ 14 ΡΡΠ°ΠΌΠΌΠΎΠ², Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΡΠΌΠΈ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΡΠΌΠΈ (ΠΈΠ· Π½ΠΈΡ
7 ΠΏΠΎΠ»ΠΈΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
), 8 ΡΡΠ°ΠΌΠΌΠΎΠ² ΠΎΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ Π»Π΅Π³ΠΊΠΈΡ
, 4 ΡΡΠ°ΠΌΠΌΠ° ΠΎΡ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ. ΠΡΠ»ΡΡΠΈΠ»ΠΎΠΊΡΡΠ½ΠΎΠ΅ ΡΠΈΠΊΠ²Π΅Π½ΡΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ»ΠΎ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΠΎΠ³Π»Π°ΡΠ½ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ΅ M.C. Enright ΠΈ B.G. Spratt (1998).Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠ΅ ΡΡΠ°ΠΌΠΌΡ, Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΠ΅ Π² ΡΡΠ΅Ρ
ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡΡ
, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠΎΠ±ΠΎΠΉ ΡΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΈΠ·ΠΎΠ»ΡΡΡ Π²ΠΈΠ΄Π° S. pneumoniae, Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ
(18 ΠΈΠ· 26) ΠΎΠ±Π»Π°Π΄Π°ΡΡ ΡΠ½ΠΈΠΊΠ°Π»ΡΠ½ΡΠΌ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠΌ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΠΌ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ²Π΅Π½ΡΡΠΈΠΏΠ° Π΄Π»Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΡΡΠ°ΠΌΠΌΠ°. ΠΠ· 14 ΡΡΠ°ΠΌΠΌΠΎΠ², Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
Ρ Π»ΠΈΡ ΠΏΠΎΠΆΠΈΠ»ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Ρ Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠΉ ΠΏΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΠ΅ΠΉ, 6 ΠΎΡΠ½ΠΎΡΠΈΠ»ΠΈΡΡ ΠΊ ΠΏΡΠΎΡΠΈΠ»Ρ Taiwan19F-14. Π‘ΡΠ΅Π΄ΠΈ ΡΡΠ°ΠΌΠΌΠΎΠ², Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
ΠΎΡ Π½ΠΎΡΠΈΡΠ΅Π»Π΅ΠΉ, ΠΏΡΠ΅Π²Π°Π»ΠΈΡΠΎΠ²Π°Π» ΡΡΠ°ΠΌΠΌ, ΠΈΠ΄Π΅Π½ΡΠΈΡΠ½ΡΠΉ ΡΡΠ°ΠΌΠΌΡ R6. Π‘ΡΠ΅Π΄ΠΈ ΡΡΠ°ΠΌΠΌΠΎΠ², Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
ΠΎΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ, ΠΏΡΠ΅Π²Π°Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ°ΠΊΠΎΠ³ΠΎ-Π»ΠΈΠ±ΠΎ Π³Π΅Π½ΠΎΡΠΈΠΏΠ° Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠ»ΡΡΠΈΠ»ΠΎΠΊΡΡΠ½ΠΎΠ΅ ΡΠΈΠΊΠ²Π΅Π½ΡΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°ΡΡ Π½ΠΎΠ²ΡΠ΅ Π³Π΅Π½ΠΎΡΠΈΠΏΡ ΠΈ Π΄Π°ΡΡ ΠΏΡΠΎΠ³Π½ΠΎΠ· ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈ ΠΎΠΏΠ°ΡΠ½ΡΡ
ΡΡΠ°ΠΌΠΌΠΎΠ² Ρ Π½ΠΎΠ²ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ
Sulfides, sulfones, and sulfoxides of the furan-2(5H)-one series. synthesis and structure
A number of 4- and 5-R-sulfanylfuran-2(5H)-one derivatives were synthesized, and their oxidation with various reagents was studied. The corresponding sulfones were obtained using hydrogen peroxide in acetic acid. 4-R-sulfanyl derivatives were selectively oxidized to sulfoxides with m-chloroperoxybenzoic acid. The molecular and crystal structures of some new sulfones and sulfoxides were determined by X-ray analysis. Β© 2014 Pleiades Publishing, Ltd
Sulfides, sulfones, and sulfoxides of the furan-2(5H)-one series. synthesis and structure
A number of 4- and 5-R-sulfanylfuran-2(5H)-one derivatives were synthesized, and their oxidation with various reagents was studied. The corresponding sulfones were obtained using hydrogen peroxide in acetic acid. 4-R-sulfanyl derivatives were selectively oxidized to sulfoxides with m-chloroperoxybenzoic acid. The molecular and crystal structures of some new sulfones and sulfoxides were determined by X-ray analysis. Β© 2014 Pleiades Publishing, Ltd
Sulfides, sulfones, and sulfoxides of the furan-2(5H)-one series. synthesis and structure
A number of 4- and 5-R-sulfanylfuran-2(5H)-one derivatives were synthesized, and their oxidation with various reagents was studied. The corresponding sulfones were obtained using hydrogen peroxide in acetic acid. 4-R-sulfanyl derivatives were selectively oxidized to sulfoxides with m-chloroperoxybenzoic acid. The molecular and crystal structures of some new sulfones and sulfoxides were determined by X-ray analysis. Β© 2014 Pleiades Publishing, Ltd
Facile Access to Optically Active 2,6-Dialkyl-1,5-Diazacyclooctanes
Β© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The chiral substituted 1,5-diazacyclooctane (1,5-DACO) is of considerable importance and has attracted attention from a wide range of fields due to their unique chemical and biological properties. Despite the application potential, further study has not been optimized due to difficulties in their synthetic accessibility. Here, we report that the 1,5-DACO bearing a chiral auxiliary obtained from the formal [4+4] cycloaddition of N-alkyl-Ξ±,Ξ²-unsaturated imines can be further derivatized by nucleophilic alkylation to give various chiral substituted 1,5-DACO derivatives. The removal of the chiral auxiliary was effectively carried out using hydrogenation over Pearlman's catalyst. This methodology allows the production of a broad range of unprecedented optically active 2,6-dialkyl-1,5-DACO, which could not be accessed by other methods
Facile Access to Optically Active 2,6-Dialkyl-1,5-Diazacyclooctanes
Β© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The chiral substituted 1,5-diazacyclooctane (1,5-DACO) is of considerable importance and has attracted attention from a wide range of fields due to their unique chemical and biological properties. Despite the application potential, further study has not been optimized due to difficulties in their synthetic accessibility. Here, we report that the 1,5-DACO bearing a chiral auxiliary obtained from the formal [4+4] cycloaddition of N-alkyl-Ξ±,Ξ²-unsaturated imines can be further derivatized by nucleophilic alkylation to give various chiral substituted 1,5-DACO derivatives. The removal of the chiral auxiliary was effectively carried out using hydrogenation over Pearlman's catalyst. This methodology allows the production of a broad range of unprecedented optically active 2,6-dialkyl-1,5-DACO, which could not be accessed by other methods