Computation of the p6 order chiral Lagrangian coefficients from the underlying theory of QCD

We present results of computing the p6 order low energy constants in the normal part of chiral Lagrangian both for two and three flavor pseudo-scalar mesons. This is a generalization of our previous work on calculating the p4 order coefficients of the chiral Lagrangian in terms of the quark self energy Sigma(p2) approximately from QCD. We show that most of our results are consistent with those we can find in the literature.Comment: 51 pages,2 figure

Unveiling the Fingerprint of Eccentric Binary Black Hole Mergers

The orbital eccentricity plays a crucial role in shaping the dynamics of binary black hole (BBH) mergers. Remarkably, our recent findings reveal a universal oscillation in essential dynamic quantities: peak luminosity $L_{\text{peak}}$, masses $M_f$, spins $\alpha_f$, and recoil velocity $V_f$ of the final remnant black hole, as the initial eccentricity $e_0$ undergoes variation. In this letter, by leveraging RIT's extensive numerical relativistic simulations of nonspinning eccentric orbital BBH mergers, we not only confirm the universal oscillation in peak amplitudes (including harmonic modes), similar to the oscillations observed in $L_{\text{peak}}$, $M_f$, $\alpha_f$, and $V_f$, but also make the first discovery of a ubiquitous spiral-like internal fine structure that correlates $L_{\text{peak}}$, $M_f$, $\alpha_f$, $V_f$, and peak amplitudes. This distinctive feature, which we term the "fingerprint" of eccentric orbital BBH mergers, carries important implications for unraveling the intricate dynamics and astrophysics associated with eccentric orbital BBH mergers.Comment: Submitted to PRL, comments are very welcom

Luminal-contact-inhibition of epithelial basal stem cell multipotency in prostate organogenesis and homeostasis.

Prostate epithelial basal cells are highly plastic in their luminal differentiation capability. Basal stem cells actively produce luminal cells during organogenesis, but become restricted in the adult prostate unless receiving oncogenic or inflammatory stimuli. Given that the number of luminal cells increases relative to basal cells through development and that equilibrium is reached in the adulthood, we hypothesize that a negative-feedback mechanism exists to inhibit basal-to-luminal differentiation. We provide evidence supporting this hypothesis by comparing murine prostatic growth in a tissue reconstitution assay with cell recombinants of different basal-to-luminal ratios. Additionally, in organoid culture, hybrid organoids derived from adjacent basal and luminal cells showed reduced basal stem cell activities, suggesting contact inhibition. Importantly, removal of adult luminal cells in vivo via either an inducible Cre/loxP-Dre/rox dual-lineage-tracing system or orthotopic trypsin injection led to robust reactivation of basal stem cell activities, which acts independent of androgen. These data illustrate the prostate organ as a distinctive paradigm where cell contact from differentiated daughter cells restricts adult stem cell multipotency to maintain the steady-state epithelial architecture