Pooled hazard ratios (HRs) for OS according to subgroup analyses.

<p>Pooled hazard ratios (HRs) for OS according to subgroup analyses.</p

Preoperative platelet lymphocyte ratio as independent predictors of prognosis in pancreatic cancer: A systematic review and meta-analysis

<div><p>Background</p><p>Recently, the preoperative platelet to lymphocyte ratio (PLR) has been found reported to predict oncologic outcomes in multiple malignancies. However, its prognostic value in patients with pancreatic cancer (PC) remains controversial. The aim of this study was to assess the prognostic value of preoperative PLR in PC.</p><p>Methods</p><p>MEDLINE, EMBASE, and Cochrane databases were searched to identify studies evaluating the prognostic significance of preoperative PLR in PC. Pooled hazard ratios (HRs) for overall survival (OS) were calculated using fixed-effects/random-effects models.</p><p>Results</p><p>A total of eight studies comprising 1,904 patients with PC were included in the meta-analysis. The pooled analysis demonstrated that elevated PLR had an association with decreased OS (HR: 1.22, 95% CI: 1.04–1.43, p = 0.02). Subgroup analysis showed that a high PLR significantly predicted poor OS in Asian studies (HR: 1.25, 95% CI: 1.03–1.52, p = 0.02), patients with metastatic disease (HR: 1.34, 95% CI: 1.01–1.77, p = 0.04) and patients with PLR >150 (HR: 1.73, 95% CI: 1.21–2.49, p = 0.003).</p><p>Conclusions</p><p>The preoperative PLR may be a significant independent prognostic factor in patients with PC.</p></div

Characteristics of the studies included in the meta-analysis.

<p>Characteristics of the studies included in the meta-analysis.</p

Flow diagram of the study selection process.

<p>Flow diagram of the study selection process.</p

Forest plots for the association between PLR and OS.

<p>Forest plots for the association between PLR and OS.</p

Metabolic Profiling for the Discovery of Structurally Diverse Gibberellins and Their Precursors from the Endophytic Fungus <i>Fusarium</i> sp. NJ-F5

Gibberellins (GAs) are well-known tetracyclic diterpenoid phytohormones since the 1950s. In this work, eight skeletally diverse GAs (1–8) including four new compounds (1–4), and three known ent-kaurene diterpenoids (9–11), were isolated from the endophytic fungus Fusarium sp. NJ-F5 by integrating mass spectrometry (MS)- and nuclear magnetic resonance (NMR)-based metabolic profiling. Their planar structures and stereochemistry were determined by extensive spectroscopic analyses including MS, NMR, as well as electronic circular dichroism and their calculations, together with single-crystal X-ray diffraction studies. As far as we know, this is a rare report of naturally occurring GAs and their detailed spectroscopic data including MS and NMR in recent decades. Compound 1, as a new member of GAs family, showed an obvious promoting effect on the seedling’s growth ofArabidopsis thaliana

Metabolic Profiling for the Discovery of Structurally Diverse Gibberellins and Their Precursors from the Endophytic Fungus <i>Fusarium</i> sp. NJ-F5

Gibberellins (GAs) are well-known tetracyclic diterpenoid phytohormones since the 1950s. In this work, eight skeletally diverse GAs (1–8) including four new compounds (1–4), and three known ent-kaurene diterpenoids (9–11), were isolated from the endophytic fungus Fusarium sp. NJ-F5 by integrating mass spectrometry (MS)- and nuclear magnetic resonance (NMR)-based metabolic profiling. Their planar structures and stereochemistry were determined by extensive spectroscopic analyses including MS, NMR, as well as electronic circular dichroism and their calculations, together with single-crystal X-ray diffraction studies. As far as we know, this is a rare report of naturally occurring GAs and their detailed spectroscopic data including MS and NMR in recent decades. Compound 1, as a new member of GAs family, showed an obvious promoting effect on the seedling’s growth ofArabidopsis thaliana

Metabolic Profiling for the Discovery of Structurally Diverse Gibberellins and Their Precursors from the Endophytic Fungus <i>Fusarium</i> sp. NJ-F5

Gibberellins (GAs) are well-known tetracyclic diterpenoid phytohormones since the 1950s. In this work, eight skeletally diverse GAs (1–8) including four new compounds (1–4), and three known ent-kaurene diterpenoids (9–11), were isolated from the endophytic fungus Fusarium sp. NJ-F5 by integrating mass spectrometry (MS)- and nuclear magnetic resonance (NMR)-based metabolic profiling. Their planar structures and stereochemistry were determined by extensive spectroscopic analyses including MS, NMR, as well as electronic circular dichroism and their calculations, together with single-crystal X-ray diffraction studies. As far as we know, this is a rare report of naturally occurring GAs and their detailed spectroscopic data including MS and NMR in recent decades. Compound 1, as a new member of GAs family, showed an obvious promoting effect on the seedling’s growth ofArabidopsis thaliana

Effect of mitochondrial nutriments on expression of Pparα, Pparδ and Mcpt-1.

<p>Total RNA was isolated from soleus muscle. <i>Ppara, Pparδ</i> and <i>Mcpt-1</i> mRNA were analyzed by means of quantitative RT-PCR with gene-specific oligonucleotide probes in muscle. The cycle number at which the various transcripts were detectable was compared to that of nuclear 18S rRNA as an internal control, and expressed as arbitrary units versus values in Wistar control taken 100. All values are mean±SEM of 12 animals in each group. *p<0.05, ** p<0.01 vs. Wistar control; #p<0.05, ##p<0.01 vs. GK control.</p

Morphometric and plasma variables in GK rats with different treatments.

<p>Values are mean±SEM of 12 animals in each group.</p>*<p>p<0.05 vs. GK control;</p>**<p>p<0.01 vs. GK control.</p