The Malaysian Medication Adherence Scale (MALMAS): Concurrent Validity Using a Clinical Measure among People with Type 2 Diabetes in Malaysia.

Medication non-adherence is a prevalent problem worldwide but up to today, no gold standard is available to assess such behavior. This study was to evaluate the psychometric properties, particularly the concurrent validity of the English version of the Malaysian Medication Adherence Scale (MALMAS) among people with type 2 diabetes in Malaysia. Individuals with type 2 diabetes, aged 21 years and above, using at least one anti-diabetes agent and could communicate in English were recruited. The MALMAS was compared with the 8-item Morisky Medication Adherence Scale (MMAS-8) to assess its convergent validity while concurrent validity was evaluated based on the levels of glycated hemoglobin (HbA1C). Participants answered the MALMAS twice: at baseline and 4 weeks later. The study involved 136 participants. The MALMAS achieved acceptable internal consistency (Cronbach's alpha=0.565) and stable reliability as the test-retest scores showed fair correlation (Spearman's rho=0.412). The MALMAS has good correlation with the MMAS-8 (Spearman's rho=0.715). Participants who were adherent to their anti-diabetes medications had significantly lower median HbA1C values than those who were non-adherence (7.90 versus 8.55%, p=0.032). The odds of participants who were adherent to their medications achieving good glycemic control was 3.36 times (95% confidence interval: 1.09-10.37) of those who were non-adherence. This confirms the concurrent validity of the MALMAS. The sensitivity of the MALMAS was 88.9% while its specificity was 29.6%. The findings of this study further substantiates the reliability and validity of the MALMAS, in particular its concurrent validity and sensitivity for assessing medication adherence of people with type 2 diabetes in Malaysia

Are Bipolar Disorder and Schizophrenia Neuroanatomically Distinct? An Anatomical Likelihood Meta-analysis

Objective: There is renewed debate on whether modern diagnostic classification should adopt a dichotomous or dimensional approach to schizophrenia and bipolar disorder. This study synthesizes data from voxel-based studies of schizophrenia and bipolar disorder to estimate the extent to which these conditions have a common neuroanatomical phenotype. Methods: A post-hoc meta-analytic estimation of the extent to which bipolar disorder, schizophrenia, or both conditions contribute to brain gray matter differences compared to controls was achieved using a novel application of the conventional anatomical likelihood estimation (ALE) method. 19 schizophrenia studies (651 patients and 693 controls) were matched as closely as possible to 19 bipolar studies (540 patients and 745 controls). Result: Substantial overlaps in the regions affected by schizophrenia and bipolar disorder included regions in prefrontal cortex, thalamus, left caudate, left medial temporal lobe, and right insula. Bipolar disorder and schizophrenia jointly contributed to clusters in the right hemisphere, but schizophrenia was almost exclusively associated with additional gray matter deficits (left insula and amygdala) in the left hemisphere. Limitation: The current meta-analytic method has a number of constraints. Importantly, only studies identifying differences between controls and patient groups could be included in this analysis. Conclusion: Bipolar disorder shares many of the same brain regions as schizophrenia. However, relative to neurotypical controls, lower gray matter volume in schizophrenia is more extensive and includes the amygdala. This fresh application of ALE accommodates multiple studies in a relatively unbiased comparison. Common biological mechanisms may explain the neuroanatomical overlap between these major disorders, but explaining why brain differences are more extensive in schizophrenia remains challenging

School Stakeholders' Experience with Navigating ICT Policy Reforms in Singapore

Using qualitative research inquiry methods, this inquiry attempts to explore how school stakeholders cope with incessant and seemingly endless transformations in schools. The central phenomenon to be studied focuses on how school stakeholders “make sense” of educational reform. In order to do this, an exploratory case study of two target schools taking part in policy reform initiatives directed at ubiquitous use of Information Communication and Technology (ICT) in a Singapore context would be the locus of this inquiry. Using Focus Group Discussions (FGDs), interviews, and observations this inquiry investigates and builds emerging explanations to sense-making experiences of stakeholders. Policy learning narratives of actors involved in the ICT-education reforms would be analysed using the lens of Actor-Network Theory (ANT). Findings from this exploratory inquiry provide insights to ongoing debates on policy learning experiences of school stakeholders in periods of uncertainty

HEALTH SEEKING BEHAVIOR TOWARDS MINOR AILMENTS AMONG UNIVERSITY STUDENTS IN MALAYSIA

Objective: This study was conducted to identify the types of minor ailments encountered by university students in Malaysia and the action taken in response to these ailments. Methods: A cross-sectional study was conducted on undergraduate students from the various faculties in a major private and a public university in Malaysia. A researcher stationed at different areas of the universities to recruit respondents. If the student agreed to participate, he/she would sign a consent form and then self-filled a structured questionnaire. Results: Of the 856 respondents included in this study, 68.6% were female and 60.6% rated their health status as ‘good’ or ‘very good’. During the one month period prior to the study, 87.4% of the respondents encountered at least one minor ailment. The five most common minor ailments encountered were headache (58.1%), common cold (42.8%), sore throat (42.6%), cough (40.3%) and back pain (27.6%). The main actions taken were rest at home and self-medication. The most common drug used for the treatment of minor ailments was paracetamol (49% of the respondents). Other drugs were used by less than 10% of the respondents. The main source of information was from parents (63.7%), followed by doctors (59.9%), internet (57.9%), pharmacists (33.9%) and friends (33.5%). Conclusion: Headache is more common among university students compared to the general population. Further studies are required to understand the cause of headache among this population

Kemahiran generik dan komitmen kerja bagi pekerja di industri kecil sederhana

Employability is a topic of discussion for new graduates. Graduates are experiencing difficulties in getting employed due to them being choosy of finding a suitable job, workplace, salary and promotion opportunities. However, the root cause of graduates failing to obtain placements in the industry should be assessed by taking into account the views of the industry itself. The study identified expectations of the industry with regards to generic skills and work commitments of employees in small and medium-sized enterprises (SMEs). Quantitative method was used as a method to obtain the data. 124 employers and 179 technicians from 150 small and medium enterprises in the state of Johor participated as the sample respondents. Data were analyzed using SPSS version 19, from which data frequencies, percentages, means, standard deviations and T-test were computed. Elements of generic skills required by the SMEs in this study were communication skills and professional skills. Besides the criteria of generic skills, work commitment comprising job responsibilities, job satisfaction and workplace environment were three important categories in SMEs. The results showed that there were no significant differences between the expectations of industries for generic skills (p=0.97) and work commitment (p=0.24). Furthermore, it was also reported that there was no significant difference between the expectations of industry for job performance (p=0.93). In conclusion, this study has shown that SMEs have similar expectations of generic skills and work commitments. Based on the findings, a pyramid for generic skills and work commitments was developed and can be used as a guide for new graduates to seek employment

Myofascial Release on Pain and Function in Adults with Low Back Pain: A systematic review

Poor posture in sitting and standing exerts stress on the spine muscle leading to non-specific low back pain (LBP). Myofascial release (MFR) on the back and leg muscles may reduce fascial tension in an individual with LBP is unclear. This review describes the effects of MFR on flexibility, pain, disability, and stress level among non-specific LBP individuals. The findings showed that the direct or indirect apply MFR on the back or lower limbs improve flexibility, pain, and disability. However, insufficient information on stress levels. The MFR therapy is recommended to enhance low back pain rehabilitation. Keywords: low back pain; myofascial release; superficial backline; back rehabilitation eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under the responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians), and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v7i21.375

Effectiveness of Manual Therapy on Pain, Disability, and Quality of Life for Elderly with Chronic Low Back Pain

Background Nowadays, manual therapy (MT) is used in treating LBP. However, the evidence of its effectiveness is inconclusive. Objectives To identify the effect of MT on pain, physical function, disability, QOL, and psychological aspects for the elderly with chronic LBP. Methods Electronic searching between the years 2012-2022 was used to retrieve articles. The assessment for quality used McMaster Critical Review Form for Quantitative Studies. Findings Only 3 articles met the inclusion criteria. Implications MT effectively improves pain, physical function, disability, QOL, and psychology among the elderly with LBP. Nevertheless, further investigation is needed to gain robust evidence for clinical practice. Keywords: Low back pain; manual therapy; elderly eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under the responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians), and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v7i21.373

Effects of Self-Myofascial Release on Pain and Flexibility among Adults with Low Back Pain

Aims: To explores the short-term effects of a self-management myofascial approach in managing LBP. Objective: Firstly; To compare self-MFR and static hamstring stretching intervention on pain and flexibility. Secondly: To determine the effect of self-MFR on pain and flexibility. Methods: Seventy participants were randomly assigned equally into intervention and control groups. The intervention participants performed self-MFR on the plantar using a tennis ball. The control group performed static hamstring stretching. Findings: There was a significant difference in flexibility between both groups (p<0.05). There was a significant effect of self-MFR on pain (t:6.21;p<0.05) and flexibility (t: -5.65 p<0.05) among LBP adults. Keywords: Low back pain; Muscle flexibility; Self - myofascial release; Pain intensity eISSN: 2398-4287 © 2023. The Authors. Published for AMER & cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), and cE-Bs (Centre for Environment-Behaviour Studies), College of Built Environment, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v8i24.4687

A New Nested Allele-Specific Multiplex Polymerase Chain Reaction Method for Haplotyping of VKORC1 Gene to Predict Warfarin Sensitivity

The vitamin K epoxide reductase complex 1 gene (VKORC1) is commonly assessed to predict warfarin sensitivity. In this study, a new nested allele-specific multiplex polymerase chain reaction (PCR) method that can simultaneously identify single nucleotide polymorphisms (SNPs) at VKORC1 381, 861, 5808, and 9041 for haplotype analysiswas developed and validated. ExtractedDNAwas amplified in the first PCR DNA, which was optimized by investigating the effects of varying the primer concentrations, annealing temperature, magnesium chloride concentration, enzyme concentration, and the amount of DNA template. The amplification products produced from the first round of PCR were used as templates for a second PCR amplification in which both mutant and wild-type primers were added in separate PCR tubes, followed by optimization in a similar manner. The final PCR products were resolved by agarose gel electrophoresis and further analysed by using a VKORC1 genealogic tree to infer patient haplotypes. Fifty patients were identified to have H1H1, one had H1H2, one had H1H7, 31 had either H1H7 or H1H9, one had H1H9, eight had H7H7, and one had H8H9 haplotypes. This is the first method that is able to infer VKORC1 haplotypes using only conventional PCR methods