Measurements of Radiation Pressure on Diffractive Films

One of the few ways to reach distant stars is by radiation pressure, in which photon momentum is harnessed from free sunlight or extraordinarily powerful laser systems. Large but low mass light-driven sails reflect photons and transfer momentum to the sailcraft, providing large velocity from continuous acceleration. Over the past decade, demonstrative reflective light sail missions were enabled by cost-efficient small satellites and the emerging private space economy. The maneuver of these metal-coated polyimide films is mechanically cumbersome because the sail must be rapidly tilted towards and away from the sun line during navigation. Modern diffractive films such as high-efficiency single-order gratings, liquid crystal cycloidal diffractive wave-plates, and meta-material gratings may provide enhanced control schemes with radiation pressure tangential to the sail surface. The potential to replace motorized control components with all-optical components also offers a reduction in mass and the risk of mission failure. Before spending considerable resources sending a rocket to deploy a solar sail, it must be verified that the sail will behave as expected in a lab on Earth. This is challenging since Earth’s gravity, electro-static forces, thermal effects, and environment vibrations exceed the relatively weak effects of radiation pressure. In this dissertation, we designed and constructed an opto-mechanical torsional pendulum in a vacuum environment that measures radiation pressure on diffraction films with sub-nano-Newton precision. With the system, we observed a large component of force parallel to the surface of a diffraction grating owing to “grating momentum”. Furthermore, we proposed, designed, and validated Diffractive Beam-Rider structures that enable spatially varying forces to pull and align the sailcraft to the beam. We parametrically “cooled” the turbulence on the Beam-Rider, which demonstrates its potential for implementation on a laser sail. This experimental stability verification was performed on a centimeter-sized bi-grating and a diffractive axicon with one and two-dimensional restoring force, respectively

Translational control analysis by translationally active RNA capture/microarray analysis (TrIP–Chip)

We have developed a new approach to systematically study post-transcriptional regulation in a small number of cells. Actively translating mRNAs are associated with polysomes and the newly synthesized peptide chains are closely associated with molecular chaperones such as hsp70s, which assist in the proper folding of nascent polypeptides into higher ordered structures. These chaperones provide an anchor with which to separate actively translating mRNAs associated with polysomes from free mRNAs. Affinity capture beads were developed to capture hsp70 chaperones associated with the polysome complexes. The isolated actively translating mRNAs were used for high-throughput expression profiling analysis. Feasibility was demonstrated using an in vitro translation system with known translationally regulated mRNA transcript thymidylate synthase (TS). We further developed the approach using HCT-116 colon cancer cells with both TS and p53 as positive controls. The steady-state levels of TS and p53 mRNAs were unaltered after 5-fluorouracil treatment as assessed by real-time qRT-PCR analysis. In contrast, the protein expression and polysome-associated mRNA levels of both genes were increased. These differences in translational rate were revealed with our new approach from 500 cells. This technology has the potential to make investigation of translational control feasible with limited quantities of clinical specimens

Evolution Of Constructivism

The contrast between social constructivism and cognitive constructivism are depicted in different ways in many studies.  The purpose of this paper is to summarize the evolution of constructivism and put a focus on social constructivism from the perception of Vygotsky.  This study provides a general idea of the evolution of constructivism for people want to understand this learning theory

Using Drawing As Intervention With Children For In-Service Preschool Teachers

This study provides a basic overview of in-service preschool teachers using drawing as intervention with children.  Art therapy is used more often for the smaller children who have more difficulty to describe their emotions and feelings in recognizing words, such as anger, resentment, and different kind of abuses.  As a matter of fact, the drawing has become a preferred mode of communication for them. The final result of this study is supporting the said theory. The best predictor of behavioral intention was the in-service teachers’ attitudes while enrolling in the four-month non-credit course in Art Therapy and they believed that this would facilitate their future teaching by much more understanding the children’s behaviors through non-verbal communication and actions. The perceived behavioral control was also the significant predictor of actual application behaviors. This study can provide a valuable reference for those in-service teachers who presently do not have any experience with art as an intervention with children

Audio Time-Scale Modification with Temporal Compressing Networks

We proposed a novel approach in the field of time-scale modification on audio signals. While traditional methods use the framing technique, spectral approach uses the short-time Fourier transform to preserve the frequency during temporal stretching. TSM-Net, our neural-network model encodes the raw audio into a high-level latent representation. We call it Neuralgram, in which one vector represents 1024 audio samples. It is inspired by the framing technique but addresses the clipping artifacts. The Neuralgram is a two-dimensional matrix with real values, we can apply some existing image resizing techniques on the Neuralgram and decode it using our neural decoder to obtain the time-scaled audio. Both the encoder and decoder are trained with GANs, which shows fair generalization ability on the scaled Neuralgrams. Our method yields little artifacts and opens a new possibility in the research of modern time-scale modification. The audio samples can be found on https://ernestchu.github.io/tsm-net-demo

Reduced expression in preterm birth of sFLT-1 and PlGF with a high sFLT-1/PlGF ratio in extracellular vesicles suggests a potential biomarker

Preterm birth may have a pathological impact on intrauterine development of the fetal brain, resulting in developmental disabilities. In this study, we examine the expression of soluble Fms-like tyrosine kinase 1 (sFLT-1) and placental growth factor (PlGF), which is one of the vascular endothelial growth factors (VEGFs), as these play a key role in angiogenesis; in particular, we examine their effect on the sFLT-1/PlGF ratio in cases of preterm birth as compared to typical pregnancies. Enzyme-linked immunosorbent assay was performed on samples of maternal-derived plasma and extracellular vesicles-exosomes (EVs-EXs) isolated at the third trimester, consisting of 17 samples from cases of preterm birth and 38 control cases. Our results showed that both sFLT-1 (P=0.0014) and PlGF (P=0.0032) were significantly downregulated in cases of preterm birth compared to controls, while the sFLT-1/PIGF ratio was significantly (P=0.0008) increased in EVs-EXs, but not in maternal plasma. Our results suggest that this reduced expression of sFLT-1 and PlGF with an elevated sFLT-1/PlGF ratio in EVs-EXs may represent a potential biomarker for prediction of PTB

Measurements of Radiation Pressure Owing to the Grating Momentum

The radiation pressure force on a nearly single-order diffraction grating was measured for a transmission grating near the Littrow angles at wavelengths of 808 and 447 nm. The component of force parallel to the grating agreed well with our prediction, being proportional to the product of the grating order and the ratio of the wavelength and grating period. The normal component of force varied with the incident angle, vanishing near the Littrow angle as expected. The measurements verify a correspondence between the Fourier grating momentum and the mechanical momentum. This Letter provides opportunities for in-space fly-by-light sailcraft as well as terrestrial applications