Variability of Subglacial Drainage Across the Greenland Ice Sheet: A Joint Model/Radar Study

Over the last several decades, the majority of the Greenland outlet glaciers have accelerated due to the increased warming in both the atmosphere and the oceans around the polar latitudes. While there is a clear overall acceleration trend over this period, there is significant variability in the glacier responses to climate on seasonal and year-to-year timescales. This variability observed around Greenland is very likely tied to the differences in internal dynamics of individual glaciers and the complex interaction with its local environment. Here I investigate the interaction between ice and water along the ice base as an important mechanism contributing to the observed variability among glaciers in Greenland. I use a range of modeling and radar sounding approaches to study the subglacial hydrology for three types of outlet glaciers, including slow moving, marine terminating glaciers in the west, a land-terminating system in the southwest, and a fast moving, marine-terminating glacier in northern Greenland. These case studies allow me to characterize the basal water distribution, its variability throughout the year and how this drainage behavior varies across different regions of Greenland. To start, I use a hydrological routing model to characterize the subglacial hydrology for three neighboring slow moving (< 100myr−1), marine terminating glaciers in western Greenland. The hydrologic model allows me to examine the sensitivity of basal water routing to subtle changes in basal water pressures. My results reveal that Greenland subglacial drainage can be rerouted across 100’s of km in response to changes in basal water pressures as small as 10%. I conclude that water piracy and subsequent dramatic changes in ice velocity, similar to that observed around the Siple Coast in West Antarctica, can occur in Greenland. Next, I move to a more data-orientated approach and use airborne radar sounding to examine the seasonal variability of basal water distribution. To robustly characterize basal water from radar bed power, I use a novel radar analysis approach that integrates a thermomechanical ice-sheet model to predict the spatial variations of radar attenuation. I improve this approach by including a least-squares minimization to correct for power offsets due to the different radar systems deployed in multiple field seasons. This improved method is first applied to two land-terminating glaciers in the southwest, Russell Glacier, and Isunnguata Sermia. Using two seasons of radar sounding data, I find that the basal water distribution can change between the wintertime and the summertime. My results reveal that during the winter, water resides primarily in small pockets on top of bedrock ridges. In the summer, these pockets of water on the ridges connect and drain into the nearby basal troughs. This seasonal shift in the basal water distribution is actively controlled by the material properties of the bed. Therefore, in addition to the bed topography, the permeability of the bed and the presence of basal sediments could also exert a critical influence on the seasonal development of subglacial drainage. Finally, I apply the radar analysis approach to a fast-flowing marine terminating glacier for Petermann Glacier in Northern Greenland. Here I incorporate an additional step to address the spatial variation in ice chemistry and its effect on radar attenuation. I use this approach to examine the relationship between basal water, ice deformation and the onset of glacier flow. In addition to finding basal water in the fastest flowing region near the ice margin, I identify substantial basal water in the ice sheet interior where meltwater must either be related to the advection of water from upstream or be generated by internal heating due to ice deformation. My results show there are three basal water networks beneath Petermann that connect the ice sheet interior to the margin. Together, the interaction between these basal water networks and the ice deformation enhances and sustains fast flow in the interior of the Petermann catchment. Overall, the research presented in this dissertation suggests that subglacial hydrology is high variable in both space and time. This variation in the hydrologic system can influence the fundamental structure of the ice sheet through changing the transport and storage of basal water and through interacting with ice deformation and the thermal properties of the bed

Desire for experiential travel, avoidance of rituality and social esteem: An empirical study of consumer response to tourism innovation

AbstractThis study investigates tourist consumption responses toward tourism innovation. To measure tourist responses, this study posits three key consumption drivers, namely social esteem, desire for experiential travel, and avoidance against rituality of tourism settings (a subscale of need for uniqueness) and models consumers’ affective response within the context of tourism innovation. It involves 295 respondents in an empirical survey. The findings affirm the three drivers toward tourist consumption behavior. Avoidance of rituality reflects tourist preference toward tourism product and service innovation. Desire for experiential travel and the pursuit of social esteem signify tourism management and marketing innovation. Social esteem, need for status and creative choice have significant influence on tourists’ affective responses. Acquiring unique tourist products, desire for experiential travel and seeking social esteem are important motivations for tourist consumption. The implications of the study enrich the existing literature of consumer behavior and tourist consumption in response to tourism innovation

Complex Basal Thermal Transition Near the Onset of Petermann Glacier, Greenland

The basal thermal regime of ice sheets exerts a strong control on ice‐sheet stability and the onset of rapidly streaming flow. However, the nature of this thermal transition where sliding initiates is largely unconstrained by geophysical observations. In the Greenland Ice Sheet, topographic troughs or elevated geothermal heat fluxes typically define the onset of outlet glaciers. In contrast, Petermann Glacier in Northern Greenland does not have any distinct bed troughs or localized geothermal heating associated with its onset, making it an ideal site to investigate the basal thermal state and examine its role in the onset of Petermann Glacier. Here we use radar bed reflectivity and an ice‐sheet thermomechanical model to examine the basal thermal regime beneath Petermann Glacier. Our results reveal a complex thermal transition near the onset of Petermann Glacier. As the bed shifts from largely frozen to largely thawed with increasing distances from the ice divide, our results show that this thermal transition happens through alternating bands of frozen and thawed bands. The complex thermal state across the onset region suggests that lateral meltwater injection and local meltwater production determine the location of Petermann Glacier. Given the lack of topographic pinning at the onset location, the upstream margin of Petermann is vulnerable to migrate depending on a combination of advective cooling and meltwater supply from the interior of the ice sheet

Rerouting of subglacial water flow between neighboring glaciers in West Greenland

Investigations of the Greenland ice sheet's subglacial hydrological system show that the connectivity of different regions of the system influences how the glacier velocity responds to variations in surface melting. Here we examine whether subglacial water flow paths can be rerouted beneath three outlet glaciers in the ablation zone of western Greenland. We use Lamont-Doherty and Center for Remote Sensing of Ice Sheets of University of Kansas (CReSIS) ice-penetrating radar data to create a new ice thickness map. We then use a simple subglacial water flow model to examine whether flow paths can be rerouted and identify the topographic conditions that are sensitive to subglacial rerouting. By varying water pressures within an observationally constrained range, we show that moderate changes in pressure can cause flow paths to reroute and exchange water from one subglacial catchment to another. Flow across subglacial overdeepenings is particularly sensitive to rerouting. These areas have low hydraulic gradients driving flow, so subtle water pressure variations have a strong influence on water flow direction. Based on correlations between water flow paths and ice velocity changes, we infer that water piracy between neighboring catchments can result in a different spatial pattern of hydrologically induced ice velocity speedup depending on the amount and timing of surface melt. The potential for subglacial water to reroute across different catchments suggests that multiple hydrographs from neighboring glaciers are likely necessary to accurately ascertain melt budgets from proglacial point measurements. The relationship between surface runoff, ice dynamics, and proglacial discharge can be altered by rerouting of subglacial water flow within and across outlet glaciers

Sarcoma of the Larynx: Treatment Results and Literature Review

BackgroundSarcomas of the larynx are rare neoplasms that constitute less than 1% of laryngeal malignancies. A Medline search found no large series focusing on laryngeal sarcomas. We reviewed the cases of laryngeal sarcomas treated in our cancer center and compared our experiences and treatment results with those from other centers.MethodsA retrospective review of 10 patients with laryngeal sarcoma treated in our institute between 1980 and 2000 was done to identify tumor characteristics, therapeutic modalities, and treatment outcomes.ResultsThe patients showed a male predominance (9/10) and presented 8 types of pathology. Nine patients underwent surgery, including 2 total laryngectomy, 4 partial laryngectomy, and 3 endoscopic laser cordectomy. During a median follow-up of 92 months, the 5-year overall survival and disease-specific survival were 76% and 90%, respectively. Two patients developed recurrence, including 1 local recurrence and 1 distant metastasis.ConclusionSurgical intervention was the first choice in the treatment of laryngeal sarcomas. The prognosis is relatively good when compared with sarcoma originating from other anatomic sites

Validation and application of health utilities index in Chinese subjects with down syndrome

Objectives: The objectives of the study were (1) to validate the Chinese version of Health Utilities Index (HUI-Ch); (2) to examine the Health-related Quality of Life (HRQoL) of Chinese subjects with Down syndrome (DS); and (3) to study the impact of chronic health conditions on HRQoL of Chinese with DS. Methods: The multiple choice questionnaire for scoring Health Utilities Index Mark 2 (HUI2) and Health Utilities Index Mark 3 (HUI3) was translated and validated. In addition to the HRQoL scores from HUI2 and HUI3, proxy-data on socio-demographics, and 10 common chronic health conditions for people with DS were collected and analyzed. Data analysis involves multiple imputation and multiple regression analysis to predict variations in HRQoL in relation to different factors. Lastly, a gradient interval was constructed on the number of chronic health conditions in relation to HRQoL. Results: HUI-Ch was validated according to standard guidelines. People with DS were found to have a lower HRQoL as compared to the general population, with the majority categorized as moderate or severe on the scale. Behavioral and hearing problems on HUI2, and hearing problems on HUI3 were found to be statistically significant predictors of a lower HRQoL score. A significant gradient relationship existed showing when the number of health problems increased, the HRQoL scores decreased. Conclusions: HUI-Ch is a valid instrument to assess HRQoL. It can have broad application in Chinese subjects with DS including the study of the impact of different chronic health conditions on their quality of life. The quantifiable nature of HUI-Ch will facilitate longitudinal study on the well-being of subjects with DS and evaluation of effectiveness of intervention programs in the near future

How students cope with part-time study

This study provides a qualitative test and illustration of a model of how students cope with the demands of part-time study. The model shows that students who are successful in finding the time to complete the requirements of part-time courses do so by adopting three mechanisms; sacrifice, support and the negotiation of arrangements. All three mechanisms operate in four domains, namely work, family, social lives and the self. The mechanisms and domains were related together in a three by four matrix. Data to verify and illuminate the model were gathered by the researchers through an on-line forum discussion on the topic of coping with part-time study. The researchers themselves were studying part-time in a course called Adult Education and Professional Development. Analysis of the data showed that the work domain was very important but little adaptation was possible. The family was seen as the most important domain and all three mechanisms were used. Time was commonly found for part-time study by sacrificing social lives. The self-domain was interpreted as important in establishing motivation and self-determination

Global sagittal alignment after surgery of right thoracic idiopathic scoliosis in adolescents and adults with and without thoracic hypokyphosis

The study procedure was conducted in accordance to guidelines approved by the institutional clinical research ethics committee (CREC No. 2016.722) and the Declaration of Helsinki. Written informed consent was obtained from all subjects and their parents before participating in this study.AbstractThis study aimed to characterize global sagittal alignment in adolescent idiopathic scoliosis (AIS) with normal kyphosis (NTK, kyphosis &gt; 10°) and with thoracic hypokyphosis (THK, kyphosis &lt; 10°), before and after posterior spinal fusion, and compare them with asymptomatic controls. 27 AIS girls and young adults with right thoracic curves were included (seventeen with age ≤ 18 years, then age &gt; 21). Biplanar radiographies were acquired at baseline, immediate post-operatively, 1-year and 2-year follow-up, and 3D reconstruction of the spine and pelvis was performed. NTK and THK showed different global sagittal alignment, as well as differences compared to controls. AIS with THK at baseline had higher SVA/SFD (2.0 ± 2.9 vs − 0.4 ± 1.9; P &lt; 0.05) and OD-HA (0.2 ± 1.4° vs − 1.3 ± 1.6°; P &lt; 0.05) than controls, indicating that THK had compensated balance with unusual forward leaning posture. Immediately post-operation, SVA/SFD remained high (1.3 ± 3.0) while OD-HA reversed (− 1.2 ± 1.7°), indicating that THK patients had found partially compensated balance. After 2-yeas, both SVA/SFD (− 1.3 ± 2.1) and OD-HA (− 1.4 ± 0.9°) were normalized. The changes in global sagittal alignment and mechanism of balance are different in AIS with or without THK. As the head plays a critical role on balance during immediate and delayed post-operation, OD-HA can be complementary parameter for assessing global balance during post-operative follow-up of AIS patients with THK.The investigation was fully supported by a grant from the General Research Funding of Hong Kong (Project no. 14206716) (W.C.W.C.), and a funding from the BiomecAM Chair Program on Musculoskeletal Modeling (with the support of Société Générale, Covea, Yves Cotrel Foundation, ParisTech Foundation and Proteor) (C.V.)

MicroRNA clusters integrate evolutionary constraints on expression and target affinities : the miR-6/5/4/286/3/309 cluster in Drosophila

This research was supported by the Hong Kong Research Grant Council GRF Grant (14103516), The Chinese University of Hong Kong Direct Grant (4053248), and TUYF Charitable Trust (6903957) (JHLH).A striking feature of microRNAs is that they are often clustered in the genomes of animals. The functional and evolutionary consequences of this clustering remain obscure. Here, we investigated a microRNA cluster miR-6/5/4/286/3/309 that is conserved across drosophilid lineages. Small RNA sequencing revealed expression of this microRNA cluster in Drosophila melanogaster leg discs, and conditional overexpression of the whole cluster resulted in leg appendage shortening. Transgenic overexpression lines expressing different combinations of microRNA cluster members were also constructed. Expression of individual microRNAs from the cluster resulted in a normal wild-type phenotype, but either the expression of several ancient microRNAs together (miR-5/4/286/3/309) or more recently evolved clustered microRNAs (miR-6-1/2/3) can recapitulate the phenotypes generated by the whole-cluster overexpression. Screening of transgenic fly lines revealed down-regulation of leg patterning gene cassettes in generation of the leg-shortening phenotype. Furthermore, cell transfection with different combinations of microRNA cluster members revealed a suite of downstream genes targeted by all cluster members, as well as complements of targets that are unique for distinct microRNAs. Considered together, the microRNA targets and the evolutionary ages of each microRNA in the cluster demonstrates the importance of microRNA clustering, where new members can reinforce and modify the selection forces on both the cluster regulation and the gene regulatory network of existing microRNAs.PostprintPeer reviewe

A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis

Background and aims: With an increasing number of Clinical Practice Guidelines (CPGs) addressing primary prevention of food allergy and atopic dermatitis, it is timely to undertake a comprehensive assessment of the quality and consistency of recommendations and evaluation of their implementability in different geographical settings. Methods: We systematically reviewed CPGs from 8 international databases and extensive website searches. Seven reviewers screened records in any language and then used the AGREE II and AGREE REX instruments to critically appraise CPGs published between January 2011 and April 2022. Results: Our search identified 2138 relevant articles, of which 30 CPGs were eventually included. Eight (27%) CPGs were shortlisted based on our predefined quality criteria of achieving scores \u3e70% in the “Scope and Purpose” and “Rigour of Development” domains of the AGREE II instrument. Among the shortlisted CPGs, scores on the “Applicability” domain were generally low, and only 3 CPGs rated highly in the “Implementability” domain of AGREE-REX, suggesting that the majority of CPGs fared poorly on global applicability. Recommendations on maternal diet and complementary feeding in infants were mostly consistent, but recommendations on use of hydrolysed formula and supplements varied considerably. Conclusion: The overall quality of a CPG for Food Allergy and Atopic Dermatitis prevention did not correlate well with its global applicability. It is imperative that CPG developers consider stakeholders’ preferences, local applicability, and adapt existing recommendations to each individual population and healthcare system to ensure successful implementation. There is a need for development of high-quality CPGs for allergy prevention outside of North America and Europe. PROSPERO registration number: CRD42021265689