537 research outputs found
Averaging Robertson-Walker Cosmologies
The cosmological backreaction arises when one directly averages the Einstein
equations to recover an effective Robertson-Walker cosmology, rather than
assuming a background a priori. While usually discussed in the context of dark
energy, strictly speaking any cosmological model should be recovered from such
a procedure. We apply the Buchert averaging formalism to linear
Robertson-Walker universes containing matter, radiation and dark energy and
evaluate numerically the discrepancies between the assumed and the averaged
behaviour, finding the largest deviations for an Einstein-de Sitter universe,
increasing rapidly with Hubble rate to a 0.01% effect for h=0.701. For the LCDM
concordance model, the backreaction is of the order of Omega_eff~4x10^-6, with
those for dark energy models being within a factor of two or three. The impacts
at recombination are of the order of 10^-8 and those in deep radiation
domination asymptote to a constant value. While the effective equations of
state of the backreactions in Einstein-de Sitter, concordance and quintessence
models are generally dust-like, a backreaction with an equation of state
w_eff<-1/3 can be found for strongly phantom models.Comment: 18 pages, 11 figures, ReVTeX. Updated to version accepted by JCA
Consistent perturbations in an imperfect fluid
We present a new prescription for analysing cosmological perturbations in a
more-general class of scalar-field dark-energy models where the energy-momentum
tensor has an imperfect-fluid form. This class includes Brans-Dicke models,
f(R) gravity, theories with kinetic gravity braiding and generalised galileons.
We employ the intuitive language of fluids, allowing us to explicitly maintain
a dependence on physical and potentially measurable properties. We demonstrate
that hydrodynamics is not always a valid description for describing
cosmological perturbations in general scalar-field theories and present a
consistent alternative that nonetheless utilises the fluid language. We apply
this approach explicitly to a worked example: k-essence non-minimally coupled
to gravity. This is the simplest case which captures the essential new features
of these imperfect-fluid models. We demonstrate the generic existence of a new
scale separating regimes where the fluid is perfect and imperfect. We obtain
the equations for the evolution of dark-energy density perturbations in both
these regimes. The model also features two other known scales: the Compton
scale related to the breaking of shift symmetry and the Jeans scale which we
show is determined by the speed of propagation of small scalar-field
perturbations, i.e. causality, as opposed to the frequently used definition of
the ratio of the pressure and energy-density perturbations.Comment: 40 pages plus appendices. v2 reflects version accepted for
publication in JCAP (new summary of notation, extra commentary on choice of
gauge and frame, extra references to literature
Infrared effects in inflationary correlation functions
In this article, I briefly review the status of infrared effects which occur
when using inflationary models to calculate initial conditions for a subsequent
hot, dense plasma phase. Three types of divergence have been identified in the
literature: secular, "time-dependent" logarithms, which grow with time spent
outside the horizon; "box-cutoff" logarithms, which encode a dependence on the
infrared cutoff when calculating in a finite-sized box; and "quantum"
logarithms, which depend on the ratio of a scale characterizing new physics to
the scale of whatever process is under consideration, and whose interpretation
is the same as conventional field theory. I review the calculations in which
these divergences appear, and discuss the methods which have been developed to
deal with them.Comment: Invited review for focus section of Classical & Quantum Gravity on
nonlinear and nongaussian perturbation theory. Some improvements compared to
version which will appear in CQG, especially in Sec. 2.3. 30 pages +
references
Pure kinetic k-essence as the cosmic speed-up
In this paper, we consider three types of k-essence. These k-essence models
were presented in the parametric forms. The exact analytical solutions of the
corresponding equations of motion are found. It is shown that these k-essence
models for the presented solutions can give rise to cosmic acceleration.Comment: 10 pages, typos corrected, main results remain the same, minor
changes to match IJTP accepted versio
Weak lensing generated by vector perturbations and detectability of cosmic strings
We study the observational signature of vector metric perturbations through
the effect of weak gravitational lensing. In the presence of vector
perturbations, the non-vanishing signals for B-mode cosmic shear and curl-mode
deflection angle, which have never appeared in the case of scalar metric
perturbations, naturally arise. Solving the geodesic and geodesic deviation
equations, we drive the full-sky formulas for angular power spectra of weak
lensing signals, and give the explicit expressions for E-/B-mode cosmic shear
and gradient-/curl-mode deflection angle. As a possible source for seeding
vector perturbations, we then consider a cosmic string network, and discuss its
detectability from upcoming weak lensing and CMB measurements. Based on the
formulas and a simple model for cosmic string network, we calculate the angular
power spectra and expected signal-to-noise ratios for the B-mode cosmic shear
and curl-mode deflection angle. We find that the weak lensing signals are
enhanced for a smaller intercommuting probability of the string network, ,
and they are potentially detectable from the upcoming cosmic shear and CMB
lensing observations. For , the minimum detectable tension of
the cosmic string will be down to . With a
theoretically inferred smallest value , we could even detect the
string with .Comment: 39 pages, 5 figures, v2: references added, minor corrections, v3:
matches version published in JCA
Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer
Total cytosolic cathepsin D (Cat D) levels were estimated by an immunoradiometric assay in a series of 156 consecutive patients with surgical stages I–III primary endometrial adenocarcinoma. Simultaneously, the tissue content of both oestrogen (ER) and progesterone (PR) receptors, and p185HER-2/neu, DNA content (ploidy), and the fraction of S-phase cells (S-phase) were also estimated. Tumoral Cat D content ranged from 0 to 243 pmol mg−1 protein (median 44 pmol mg−1 protein) and was not associated with any of the established clinicopathological and biological prognostic variables, with the exception of a weak positive correlation with the tumoral p185HER-2/neu levels. Univariable analysis performed on a subset of 97 patients, followed for a minimum of 2 years or until death, showed that patient age at diagnosis, high histological grade, advanced surgical stage, vascular invasion, positive peritoneal cytology, low levels of Cat D, negative ER and PR status, aneuploidy, and high S-phase were predictive of the presence of persistent or recurrent disease. However, multivariable analysis revealed that only histological grade, surgical stage, Cat D and PR were significantly associated with the patient's outcome. From these findings, we conclude that Cat D is an independent prognostic factor in endometrial adenocarcinoma, its low levels being associated with a worse clinical outcome. © 1999 Cancer Research Campaig
Caffeic acid phenethyl ester promotes haematopoietic stem/progenitor cell homing and engraftment
Electrically Guiding Migration of Human Induced Pluripotent Stem Cells
A major road-block in stem cell therapy is the poor homing and integration of transplanted stem cells with the targeted host tissue. Human induced pluripotent stem (hiPS) cells are considered an excellent alternative to embryonic stem (ES) cells and we tested the feasibility of using small, physiological electric fields (EFs) to guide hiPS cells to their target. Applied EFs stimulated and guided migration of cultured hiPS cells toward the anode, with a stimulation threshold of <30 mV/mm; in three-dimensional (3D) culture hiPS cells remained stationary, whereas in an applied EF they migrated directionally. This is of significance as the therapeutic use of hiPS cells occurs in a 3D environment. EF exposure did not alter expression of the pluripotency markers SSEA-4 and Oct-4 in hiPS cells. We compared EF-directed migration (galvanotaxis) of hiPS cells and hES cells and found that hiPS cells showed greater sensitivity and directedness than those of hES cells in an EF, while hES cells migrated toward cathode. Rho-kinase (ROCK) inhibition, a method to aid expansion and survival of stem cells, significantly increased the motility, but reduced directionality of iPS cells in an EF by 70–80%. Thus, our study has revealed that physiological EF is an effective guidance cue for the migration of hiPS cells in either 2D or 3D environments and that will occur in a ROCK-dependent manner. Our current finding may lead to techniques for applying EFs in vivo to guide migration of transplanted stem cells
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