The Federal Reserve's Primary Dealer Credit Facility

As liquidity conditions in the "repo market"--the market where broker-dealers obtain financing for their securities--deteriorated following the near-bankruptcy of Bear Stearns in March 2008, the Federal Reserve took the step of creating a special facility to provide overnight loans to dealers that have a trading relationship with the Federal Reserve Bank of New York. Six months later, in the wake of new strains in the repo market, the Fed expanded the facility by broadening the types of collateral accepted for loans. Both initiatives were designed to help restore the orderly functioning of the market and to prevent the spillover of distress to other financial firms.Federal Reserve Bank of New York ; Loans ; Financial crises ; Brokers

The XO Planetary Survey Project - Astrophysical False Positives

Searches for planetary transits find many astrophysical false positives as a by-product. There are four main types analyzed in the literature: a grazing-incidence eclipsing binary star, an eclipsing binary star with a small radius companion star, a blend of one or more stars with an unrelated eclipsing binary star, and a physical triple star system. We present a list of 69 astrophysical false positives that had been identified as candidates of transiting planets of the on-going XO survey. This list may be useful in order to avoid redundant observation and characterization of these particular candidates independently identified by other wide-field searches for transiting planets. The list may be useful for those modeling the yield of the XO survey and surveys similar to it. Subsequent observations of some of the listed stars may improve mass-radius relations, especially for low-mass stars. From the candidates exhibiting eclipses, we report three new spectroscopic double-line binaries and give mass function estimations for 15 single lined spectroscopic binaries.Comment: 13 pages, 4 figures, accepted to ApJ

An Allosteric Mechanism for Inhibiting HIV-1 Integrase with a Small Molecule

HIV-1 integrase (IN) is a validated target for developing antiretroviral inhibitors. Using affinity acetylation and mass spectrometric (MS) analysis, we previously identified a tetra-acetylated inhibitor (2E)-3-[3,4-bis(acetoxy)phenyl]-2-propenoate-N-[(2E)-3-[3,4-bis(acetyloxy)phenyl]-1-oxo-2-propenyl]-L-serine methyl ester; compound 1] that selectively modified Lys173 at the IN dimer interface. Here we extend our efforts to dissect the mechanism of inhibition and structural features that are important for the selective binding of compound 1. Using a subunit exchange assay, we found that the inhibitor strongly modulates dynamic interactions between IN subunits. Restricting such interactions does not directly interfere with IN binding to DNA substrates or cellular cofactor lens epithelium-derived growth factor, but it compromises the formation of the fully functional nucleoprotein complex. Studies comparing compound 1 with a structurally related IN inhibitor, the tetra-acetylated-chicoric acid derivative (2R,3R)-2,3-bis[[(2E)-3-[3,4-bis(acetyloxy)phenyl]-1-oxo-2-propen-1-yl]oxy]-butanedioic acid (compound 2), indicated striking mechanistic differences between these agents. The structures of the two inhibitors differ only in their central linker regions, with compounds 1 and 2 containing a single methyl ester group and two carboxylic acids, respectively. MS experiments highlighted the importance of these structural differences for selective binding of compound 1 to the IN dimer interface. Moreover, molecular modeling of compound 1 complexed to IN identified a potential inhibitor binding cavity and provided structural clues regarding a possible role of the central methyl ester group in establishing an extensive hydrogen bonding network with both interacting subunits. The proposed mechanism of action and binding site for the small-molecule inhibitor identified in the present study provide an attractive venue for developing allosteric inhibitors of HIV-1 IN

Survey for Transiting Extrasolar Planets in Stellar Systems IV: Variables in the Field of NGC 1245

The Survey for Transiting Extrasolar Planets in Stellar Systems (STEPSS) project is a search for planetary transits in open clusters. In this paper, we analyze the STEPSS observations of the open cluster NGC 1245 to determine the variable star content of the cluster. Out of 6787 stars observed with V < 22, of which ~870 are cluster members, we find 14 stars with clear intrinsic variability that are potential cluster members, and 29 clear variables that are not cluster members. None of these variables have been previously identified. We present light curves, finding charts, and stellar/photometric data on these variable objects. Several of the interacting binaries have estimated distances consistent with the cluster distance determined from isochrone fits to the color magnitude diagram. Four stars at the main sequence turnoff of the cluster have light curves consistent with gamma Doradus variability. If these gamma Doradus candidates are confirmed, they represent the oldest and coolest members of this class of variable discovered to date.Comment: 20 pages, 15 figures. Submitted to AJ. PDF version with full-resolution figures at http://www.astronomy.ohio-state.edu/~pepper/ms.pd

Planetary Candidates Observed by Kepler IV: Planet Sample from Q1-Q8 (22 Months)

We provide updates to the Kepler planet candidate sample based upon nearly two years of high-precision photometry (i.e., Q1-Q8). From an initial list of nearly 13,400 threshold crossing events, 480 new host stars are identified from their flux time series as consistent with hosting transiting planets. Potential transit signals are subjected to further analysis using the pixel-level data, which allows background eclipsing binaries to be identified through small image position shifts during transit. We also re-evaluate Kepler Objects of Interest (KOIs) 1-1609, which were identified early in the mission, using substantially more data to test for background false positives and to find additional multiple systems. Combining the new and previous KOI samples, we provide updated parameters for 2738 Kepler planet candidates distributed across 2017 host stars. From the combined Kepler planet candidates, 472 are new from the Q1-Q8 data examined in this study. The new Kepler planet candidates represent ~40% of the sample with R_P ~ 1 R_⊕ and represent ~40% of the low equilibrium temperature (T_(eq) < 300 K) sample. We review the known biases in the current sample of Kepler planet candidates relevant to evaluating planet population statistics with the current Kepler planet candidate sample