The use of gastric alimetry® for specific patient phenotyping in gastroduodenal disorders in comparison to gastric emptying scintigraphy

Background: Gastric emptying testing (GET), while useful for evaluating gastric motility, is not specific nor sensitive for neuromuscular disorders. However, Gastric Alimetry® (GA) is a novel medical test that uses gastric mapping and validated symptom profiling. The current study compared the patient-specific phenotyping from GA with GET

[In Press] Normative values for body surface gastric mapping evaluations of gastric motility using gastric alimetry : spectral analysis

INTRODUCTION: Body surface gastric mapping (BSGM) is a new noninvasive test of gastric function. BSGM offers several novel and improved biomarkers of gastric function capable of differentiating patients with overlapping symptom profiles. The aim of this study was to define normative reference intervals for BSGM spectral metrics in a population of healthy controls. METHODS: BSGM was performed in healthy controls using Gastric Alimetry (Alimetry, New Zealand) comprising a stretchable high-resolution array (8 3 8 electrodes; 196 cm2), wearable Reader, and validated symptom-logging App. The evaluation encompassed a fasting baseline (30 minutes), 482 kCal meal, and 4-hour postprandial recording. Normative reference intervals were calculated for BSGM metrics including the Principal Gastric Frequency, Gastric Alimetry Rhythm Index (a measure of the concentration of power in the gastric frequency band over time), body mass index (BMI)–adjusted amplitude (mV), and fed:fasted amplitude ratio. Data were reported as median and reference interval (5th and/or 95th percentiles). RESULTS: A total of 110 subjects (55% female, median age 32 years [interquartile range 24–50], median BMI 23.8 kg/m2 [interquartile range 21.4–26.9]) were included. The median Principal Gastric Frequency was 3.04 cycles per minute; reference interval: 2.65–3.35 cycles per minute. The median Gastric Alimetry Rhythm Index was 0.50; reference interval: ‡0.25. The median BMI-adjusted amplitude was 37.6 mV; reference interval: 20–70 mV. The median fed:fasted amplitude ratio was 1.85; reference interval ‡1.08. A higher BMI was associated with a shorter meal-response duration (P 5 0.014). DISCUSSION: This study provides normative reference intervals for BSGM spectral data to inform diagnostic interpretations of abnormal gastric function