197 research outputs found
Philosophical Aspects of Quantum Information Theory
Quantum information theory represents a rich subject of discussion for those
interested in the philosphical and foundational issues surrounding quantum
mechanics for a simple reason: one can cast its central concerns in terms of a
long-familiar question: How does the quantum world differ from the classical
one? Moreover, deployment of the concepts of information and computation in
novel contexts hints at new (or better) means of understanding quantum
mechanics, and perhaps even invites re-assessment of traditional material
conceptions of the basic nature of the physical world. In this paper I review
some of these philosophical aspects of quantum information theory, begining
with an elementary survey of the theory, seeking to highlight some of the
principles and heuristics involved. We move on to a discussion of the nature
and definition of quantum information and deploy the findings in discussing the
puzzles surrounding teleportation. The final two sections discuss,
respectively, what one might learn from the development of quantum computation
(both about the nature of quantum systems and about the nature of computation)
and consider the impact of quantum information theory on the traditional
foundational questions of quantum mechanics (treating of the views of
Zeilinger, Bub and Fuchs, amongst others).Comment: LaTeX; 55pp; 3 figs. Forthcoming in Rickles (ed.) The Ashgate
Companion to the New Philosophy of Physic
Quantum Mechanics on Spacetime I: Spacetime State Realism
What ontology does realism about the quantum state suggest? The main extant
view in contemporary philosophy of physics is wave-function realism. We
elaborate the sense in which wave-function realism does provide an ontological
picture; and defend it from certain objections that have been raised against
it. However, there are good reasons to be dissatisfied with wave-function
realism, as we go on to elaborate. This motivates the development of an
opposing picture: what we call spacetime state realism; a view which takes the
states associated to spacetime regions as fundamental. This approach enjoys a
number of beneficial features, although, unlike wave-function realism, it
involves non-separability at the level of fundamental ontology. We investigate
the pros and cons of this non-separability, arguing that it is a quite
acceptable feature; even one which proves fruitful in the context of
relativistic covariance. A companion paper discusses the prospects for
combining a spacetime-based ontology with separability, along lines suggested
by Deutsch and HaydenComment: LaTeX; 29 pages, 1 Fig. Forthcoming in the British Journal for the
Philosophy of Scienc
Proper and Improper Separability
The distinction between proper and improper mixtures is a staple of the
discussion of foundational questions in quantum mechanics. Here we note an
analogous distinction in the context of the theory of entanglement. The
terminology of `proper' versus `improper' separability is proposed to mark the
distinction.Comment: 10 pages, LaTex, uses amsmath, 2 .eps figures. v2 additional figure;
and reference and footnote to Seevinck and Uffink (2001). To appear in
International Journal of Quantum Informatio
Why special relativity should not be a template for a fundamental reformulation of quantum mechanics
In a comparison of the principles of special relativity and of quantum mechanics, the former theory is marked by its relative economy and apparent explanatory simplicity. A number of theorists have thus been led to search for a small number of postulates - essentially information theoretic in nature - that would play the role in quantum mechanics that the relativity principle and the light postulate jointly play in Einstein's 1905 special relativity theory. The purpose of the present paper is to resist this idea, at least in so far as it is supposed to reveal the fundamental form of the theory. It is argued that the methodology of Einstein's 1905 theory represents a victory of pragmatism over explanatory depth; and that its adoption only made sense in the context of the chaotic state state of physics at the start of the 20th century - as Einstein well knew
Non-locality and gauge freedom in Deutsch and Hayden's formulation of quantum mechanics
Deutsch and Hayden have proposed an alternative formulation of quantum
mechanics which is completely local. We argue that their proposal must be
understood as having a form of `gauge freedom' according to which
mathematically distinct states are physically equivalent. Once this gauge
freedom is taken into account, their formulation is no longer local.Comment: 3 page
Epigenetic regulation of F2RL3 associates with myocardial infarction and platelet function
DNA hypomethylation at the F2RL3 (F2R like thrombin or trypsin receptor 3) locus has been associated with both smoking and atherosclerotic cardiovascular disease; whether these smoking-related associations form a pathway to disease is unknown. F2RL3 encodes protease-activated receptor 4, a potent thrombin receptor expressed on platelets. Given the role of thrombin in platelet activation and the role of thrombus formation in myocardial infarction, alterations to this biological pathway could be important for ischemic cardiovascular disease. METHODS: We conducted multiple independent experiments to assess whether DNA hypomethylation at F2RL3 in response to smoking is associated with risk of myocardial infarction via changes to platelet reactivity. Using cohort data (N=3205), we explored the relationship between smoking, DNA hypomethylation at F2RL3, and myocardial infarction. We compared platelet reactivity in individuals with low versus high DNA methylation at F2RL3 (N=41). We used an in vitro model to explore the biological response of F2RL3 to cigarette smoke extract. Finally, a series of reporter constructs were used to investigate how differential methylation could impact F2RL3 gene expression. RESULTS: Observationally, DNA methylation at F2RL3 mediated an estimated 34% of the smoking effect on increased risk of myocardial infarction. An association between methylation group (low/high) and platelet reactivity was observed in response to PAR4 (protease-activated receptor 4) stimulation. In cells, cigarette smoke extract exposure was associated with a 4.9% to 9.3% reduction in DNA methylation at F2RL3 and a corresponding 1.7-(95% CI, 1.2–2.4, P=0.04) fold increase in F2RL3 mRNA. Results from reporter assays suggest the exon 2 region of F2RL3 may help control gene expression. CONCLUSIONS: Smoking-induced epigenetic DNA hypomethylation at F2RL3 appears to increase PAR4 expression with potential downstream consequences for platelet reactivity. Combined evidence here not only identifies F2RL3 DNA methylation as a possible contributory pathway from smoking to cardiovascular disease risk but from any feature potentially influencing F2RL3 regulation in a similar manner
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes
The Dynamics of Intra-jurisdictional Relations in the Inuit Regions of the Canadian Arctic: An Institutionalist Perspective
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