Eunuch and Scholar - Two Ways to be ‘Indian’ Socio-Cultural Significances of the Category ‘al-Hindī ’ in the Late Mamlūk Period

From the late fourteenth to the fifteenth centuries an increased migration of ‘Indians’ (al-Hindīyūn) to the Hijaz is observable due to Jidda’s emergence as a major entrepôt in the ‘India trade’ between Mamlūk Egypt and various regions of South Asia. Besides merchants and muǧāwirūn (stu­dents and ascetics living in the vicinity of a mosque), most of the arrivals continue their journey onwards to Cairo and beyond, seeking knowledge (ṭalab al-ʿilm) along the intricate webs and networks of transregional schol­arship. At the same time, ‘Indians’ were mentioned among the four ethnic­ities that were recruited to serve as eunuchs (ṭawāšīyūn, ḫuddām) at the Mamlūk court. The period’s biographical dictionaries and chronicles refer to these migrants with the generic term ‘al-Hindī’ as a regional description that basically states the place of origin. However, beyond this nominal attach­ment, there were at least two distinct ways of being ‘Indian’ in the late Mamlūk period. Significantly, due to the profile of these narrative sources, an ‘Indian’ Selbstbild never emerges from these sources. I will argue in the following article that being ‘Indian’ was constructed as a Fremdbild within the scholarly discourse of a proliferating historiography. Such forms of ‘othering’ could play out differently. While eunuchs, on the one hand, rose to serve the highest echelons of political power, any former ethnic identity was lost in the narrative of these historiographical texts. Scholars, on the other hand, were integrated into a taxonomy of scholarly rank and merit, and thereby subjected to a distinct form of classification and othering. The assimilation into the ‘biographical templates’ of these narrative texts presents various examples of how authors perceived ‘ethnic difference’ and constructed the category al-Hindī as a complex situational marker of cultural identity

Arabic Philology at the Seventeenth-Century Mughal Court. Saʿd Allāh Khān’s and Shāh Jahān’s Enactments of the Sharḥ al-Radī

Persian narrative sources provide a colorful picture of Mughal courtly life, but in order to zoom in on cultural practices one has to turn to the artefacts of cultural pursuits. This article studies one specimen of the empirical treasure trove of Arabic manuscripts in South Asia in order to approach a lacuna in Mughal scholarship: the role of Arabic at the Mughal court. In the following, I will analyze the different paratextual layers of a manuscript of the thirteenth century Arabic grammar commentary Sharḥ al-Radī by Radī al-Dīn al-Astarābādhī to study its reading and transmission. The manuscript version represents a written artefact, which emerged out of a series of intellectual engagements. On the one hand, these textual engagements offer a perspective on the manuscript’s initial owner, Saʿd Allāh Khān (d. 1656), and his intellectual pursuits, as well as the scholarly framework in which he was brought up and worked in. On the other hand, the history of this manuscript’s circulation highlights the treatment of Arabic written artefacts at Shāh Jahān’s court. In an exemplary manner, the manuscript’s history of circulation demonstrates how courtly elites engaged with Arabic during the seventeenth century

Reading tarājim with Bourdieu: prosopographical traces of historical change in the South Asian migration to the late medieval Hijaz

This article presents a new analytical reading of one of the most popular genres in medieval Arabic historiography, biographical dictionaries, in order to address broader questions of historical change in transregional movements and scholarly group cultures. It builds on recent scholarship that focuses on shifting trade patterns across the Western Indian Ocean and in particular the intensification of commercial connections between the Red Sea region and South Asia during the 15th century to advance an argument on the sociocultural dimensions of a concomitant migration of South Asians (al-Hindīyūn, sg. al-Hindī) from the subcontinent to the Hijaz. The case study is empirically grounded in the reading of prosopographical sources, biographical entries (tarājim, sg. tarjama) of South Asians as they appear in biographical dictionaries by the famous Mamlūk historians al-Fāsī (d. 832/1429), al-Maqrīzī (d. 845/1442) and al-Sakhāwī (d. 902/1497) from the late medieval period. Most importantly, Pierre Bourdieu’s (d. 2002) theoretical concepts of “field”, “capital” and “habitus” will provide the heuristic tools to detect social and cultural significances within the narrative fabric of the historiographical texts. Interrelating these significances on an analytical level will allow the study of historical transformations on the basis of traces in the prosopographical archive. I argue that the appearance of these South Asian tarājim in the biographical works can be read as a recording of an increased migration of South Asians during the late medieval period, bringing about a social broadening and cultural diversification of the South Asian community in the Hijaz

Epoxide-Mediated CifR Repression of cif Gene Expression Utilizes Two Binding Sites in Pseudomonas aeruginosa

Pseudomonas aeruginosa secretes an epoxide hydrolase virulence factor that reduces the apical membrane expression of ABC transporters such as the cystic fibrosis transmembrane conductance regulator (CFTR). This virulence factor, named CFTR inhibitory factor (Cif), is regulated by a TetR-family, epoxide-responsive repressor known as CifR via direct binding and repression. We identified two sites of CifR binding in the intergenic space between cifR and morB, the first gene in the operon containing the cif gene. We have mapped these binding sites and found they are 27 bp in length, and they overlap the -10 and +1 sites of both the cifR and morB regulatory region and the start of transcription, respectively. In addition, we found that CifR binds to each repression site with differing affinity. Mutagenesis of these binding sites resulted in a loss of DNA binding in vitro, and mutation of one of these sites in vivo resulted in an increase in transcription of both the cif and cifR genes. We characterized cif and cifR gene expression in sputum and found that, whereas cif gene expression varied relative to an in vitro coculture control, cifR gene expression was consistently higher. Analysis of a longitudinal sample of CF isolates from nine patients revealed that Cif protein was expressed over time, although variably, and these changes could not be linked to mutations in the cifR gene or the promoters of these genes. Finally, we tested CifR responsiveness to other epoxides and showed that CifR can respond to multiple epoxides to various degrees

Prostate cancer - evidence of exercise and nutrition trial (PrEvENT):Study protocol for a randomised controlled feasibility trial

Background: A growing body of observational evidence suggests that nutritional and physical activity interventions are associated with beneficial outcomes for men with prostate cancer, including brisk walking, lycopene intake, increased fruit and vegetable intake and reduced dairy consumption. However, randomised controlled trial data are limited. The ‘Prostate Cancer: Evidence of Exercise and Nutrition Trial’ investigates the feasibility of recruiting and randomising men diagnosed with localised prostate cancer and eligible for radical prostatectomy to interventions that modify nutrition and physical activity. The primary outcomes are randomisation rates and adherence to the interventions at 6 months following randomisation. The secondary outcomes are intervention tolerability, trial retention, change in prostate specific antigen level, change in diet, change in general physical activity levels, insulin-like growth factor levels, and a range of related outcomes, including quality of life measures. Methods/design: The trial is factorial, randomising men to both a physical activity (brisk walking or control) and nutritional (lycopene supplementation or increased fruit and vegetables with reduced dairy consumption or control) intervention. The trial has two phases: men are enrolled into a cohort study prior to radical prostatectomy, and then consented after radical prostatectomy into a randomised controlled trial. Data are collected at four time points (cohort baseline, true trial baseline and 3 and 6 months post-randomisation). Discussion: The Prostate Cancer: Evidence of Exercise and Nutrition Trial aims to determine whether men with localised prostate cancer who are scheduled for radical prostatectomy can be recruited into a cohort and subsequently randomised to a 6-month nutrition and physical activity intervention trial. If successful, this feasibility trial will inform a larger trial to investigate whether this population will gain clinical benefit from long-term nutritional and physical activity interventions post-surgery. Prostate Cancer: Evidence of Exercise and Nutrition Trial (PrEvENT) is registered on the ISRCTN registry, ref number ISRCTN99048944. Date of registration 17 November 2014.10 page(s

Short Androgen Suppression and Radiation Dose Escalation in Prostate Cancer:12-Year Results of EORTC Trial 22991 in Patients With Localized Intermediate-Risk Disease

The European Organisation for Research and Treatment of Cancer (EORTC) trial 22991 (NCT00021450) showed that 6 months of concomitant and adjuvant androgen suppression (AS) improves event- (EFS, Phoenix) and clinical disease-free survival (DFS) of intermediate- and high-risk localized prostatic carcinoma, treated by external-beam radiotherapy (EBRT) at 70-78 Gy. We report the long-term results in intermediate-risk patients treated with 74 or 78 Gy EBRT, as per current guidelines. Of 819 patients randomly assigned between EBRT or EBRT plus AS started on day 1 of EBRT, 481 entered with intermediate risk (International Union Against Cancer TNM 1997 cT1b-c or T2a with prostate-specific antigen (PSA) ≥ 10 ng/mL or Gleason ≤ 7 and PSA ≤ 20 ng/mL, N0M0) and had EBRT planned at 74 (342 patients, 71.1%) or 78 Gy (139 patients, 28.9%). We report the trial primary end point EFS, DFS, distant metastasis-free survival (DMFS), and overall survival (OS) by intention-to-treat stratified by EBRT dose at two-sided α = 5%. At a median follow-up of 12.2 years, 92 of 245 patients and 132 of 236 had EFS events in the EBRT plus AS and EBRT arm, respectively, mostly PSA relapse (48.7%) or death (45.1%). EBRT plus AS improved EFS and DFS (hazard ratio [HR] = 0.53; CI, 0.41 to 0.70; P < .001 and HR = 0.67; CI, 0.49 to 0.90; P = .008). At 10 years, DMFS was 79.3% (CI, 73.4 to 84.0) with EBRT plus AS and 72.7% (CI, 66.2 to 78.2) with EBRT (HR = 0.74; CI, 0.53 to 1.02; P = .065). With 140 deaths (EBRT plus AS: 64; EBRT: 76), 10-year OS was 80.0% (CI, 74.1 to 84.7) with EBRT plus AS and 74.3% (CI, 67.8 to 79.7) with EBRT, but not statistically significantly different (HR = 0.74; CI, 0.53 to 1.04; P = .082). Six months of concomitant and adjuvant AS statistically significantly improves EFS and DFS in intermediate-risk prostatic carcinoma, treated by irradiation at 74 or 78 Gy. The effects on OS and DMFS did not reach statistical significance

Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial

BACKGROUND: STAMPEDE has previously reported that radiotherapy (RT) to the prostate improved overall survival (OS) for patients with newly diagnosed prostate cancer with low metastatic burden, but not those with high-burden disease. In this final analysis, we report long-term findings on the primary outcome measure of OS and on the secondary outcome measures of symptomatic local events, RT toxicity events, and quality of life (QoL). METHODS AND FINDINGS: Patients were randomised at secondary care sites in the United Kingdom and Switzerland between January 2013 and September 2016, with 1:1 stratified allocation: 1,029 to standard of care (SOC) and 1,032 to SOC+RT. No masking of the treatment allocation was employed. A total of 1,939 had metastatic burden classifiable, with 42% low burden and 58% high burden, balanced by treatment allocation. Intention-to-treat (ITT) analyses used Cox regression and flexible parametric models (FPMs), adjusted for stratification factors age, nodal involvement, the World Health Organization (WHO) performance status, regular aspirin or nonsteroidal anti-inflammatory drug (NSAID) use, and planned docetaxel use. QoL in the first 2 years on trial was assessed using prospectively collected patient responses to QLQ-30 questionnaire. Patients were followed for a median of 61.3 months. Prostate RT improved OS in patients with low, but not high, metastatic burden (respectively: 202 deaths in SOC versus 156 in SOC+RT, hazard ratio (HR) = 0·64, 95% CI 0.52, 0.79, p < 0.001; 375 SOC versus 386 SOC+RT, HR = 1.11, 95% CI 0.96, 1.28, p = 0·164; interaction p < 0.001). No evidence of difference in time to symptomatic local events was found. There was no evidence of difference in Global QoL or QLQ-30 Summary Score. Long-term urinary toxicity of grade 3 or worse was reported for 10 SOC and 10 SOC+RT; long-term bowel toxicity of grade 3 or worse was reported for 15 and 11, respectively. CONCLUSIONS: Prostate RT improves OS, without detriment in QoL, in men with low-burden, newly diagnosed, metastatic prostate cancer, indicating that it should be recommended as a SOC. TRIAL REGISTRATION: ClinicalTrials.gov NCT00268476, ISRCTN.com ISRCTN78818544