977 research outputs found
Electrodynamics of Media
Contains reports on four research project.Joint Services Electronics Program (Contract DAAB07-71-C-0300)U. S. Army - Research Office - Durham (Contract DAHCO4-72-C-0044
Phase-Locked Loop Stability Based on Stochastic Bounds
This is a post-peer-review, pre-copyedit version of an article published in Analog Integrated Circuits and Signal Processing. The final authenticated version is available online at: http://dx.doi.org/https://doi.org/10.1007/s10470-015-0606-zIn this paper we study the stability of a phase-locked loop (PLL) in the
presence of noise. We represent the noise as Brownian motion and model the circuit
as a nonlinear stochastic differential equation, with the noise lumped at the phase
detector input. We show that for the PLL, the theory of asymptotics of singular
diffusions can be applied and we use this theory to develop a new figure of merit
which we call a stability margin. The stability margin provides easily computable
bounds on the acceptable noise levels for which stability is guaranteed. Through
simulation, we show that such a sufficient bound provides a realistic prediction for
PLL stabilit
Computational approach to predict species-specific type III secretion system (T3SS) effectors using single and multiple genomes
Positive (effectors), negative (non-effectors), and testing sets of the five organisms that we used in the GenSET studies. (ALL Tags denotes all proteins encoded in the genome; Positive Set denotes known effector proteins used for training; Negative Set denotes non-effector proteins used for training; Testing Set denotes all proteins in the bacteria minus the Positive and Negative Sets; Positives in Testing Set denotes known effector proteins included in the Testing Set). (XLSX 48 kb
Recommended from our members
Routes To the Renaissance for Pittsfield, MA
The goal of the Master of Regional Planning Studio is to develop a studentâs techniques for collecting, analyzing, and synthesizing spatial and non-spatial data and then presenting that collective data in a manner (i.e., report, video, presentation, and charettes) that is understandable to academics, professionals, and the public. Planning Studio allows students to integrate knowledge from coursework and research, and apply such knowledge to resolving representative planning problems. At UMASS Amherst, these problems are found in neighborhood, rural, urban, and/or regional settings.
In the fall of 2015, the City of Pittsfield contracted the MRP Studio to create a vision plan to connect the goalâs of its Master Plan in 2009 to current development regulations that encourage development and redevelopment of an appropriate size, scale and design that meets the short term and long term vision of the community. The vision plan encompasses the following: Spatial and Physical Boundaries of Major Gateway Corridors: Analyze the major gateways and develop tools to make them more welcoming. Permitted Use Table and Definitions: Review, clarify, and consolidate the land-uses listed in the table to assess deficiencies and unclear definitions. Design Guidelines: Create a manual to guide architectural aesthetic standards for new retail developments. Sign Ordinance: Implement a streamlined regulation that improves sign quality. Site Plan Review: Develop thresholds to create clearer processes for review of development projects. Resolution for Split Parcels: Identify all properties that fall within two zoning districts and develop a mitigation tool. Pro Forma and Multi-Family Housing: Develop a financial model that will estimate the construction and maintenance cost of multi-family housing units and make projections for new developmentâs financial return
Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion
Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis. A high-throughput screening assay, developed to identify compounds that either inhibit or bypass VP35 IFN-antagonist function, identified five DNA intercalators as reproducible hits from a library of bioactive compounds. Four, including doxorubicin and daunorubicin, are anthracycline antibiotics that inhibit topoisomerase II and are used clinically as chemotherapeutic drugs. These compounds were demonstrated to induce IFN responses in an ATM kinase-dependent manner and to also trigger the DNA-sensing cGAS-STING pathway of IFN induction. These compounds also suppress EBOV replication in vitro and induce IFN in the presence of IFN-antagonist proteins from multiple negative-sense RNA viruses. These findings provide new insights into signaling pathways activated by important chemotherapy drugs and identify a novel therapeutic approach for IFN induction that may be exploited to inhibit RNA virus replication
Brane Tilings and Exceptional Collections
Both brane tilings and exceptional collections are useful tools for
describing the low energy gauge theory on a stack of D3-branes probing a
Calabi-Yau singularity. We provide a dictionary that translates between these
two heretofore unconnected languages. Given a brane tiling, we compute an
exceptional collection of line bundles associated to the base of the
non-compact Calabi-Yau threefold. Given an exceptional collection, we derive
the periodic quiver of the gauge theory which is the graph theoretic dual of
the brane tiling. Our results give new insight to the construction of quiver
theories and their relation to geometry.Comment: 46 pages, 37 figures, JHEP3; v2: reference added, figure 13 correcte
- âŠ