788 research outputs found
Model of Genetic Variation in Human Social Networks
Social networks exhibit strikingly systematic patterns across a wide range of
human contexts. While genetic variation accounts for a significant portion of
the variation in many complex social behaviors, the heritability of egocentric
social network attributes is unknown. Here we show that three of these
attributes (in-degree, transitivity, and centrality) are heritable. We then
develop a "mirror network" method to test extant network models and show that
none accounts for observed genetic variation in human social networks. We
propose an alternative "Attract and Introduce" model with two simple forms of
heterogeneity that generates significant heritability as well as other
important network features. We show that the model is well suited to real
social networks in humans. These results suggest that natural selection may
have played a role in the evolution of social networks. They also suggest that
modeling intrinsic variation in network attributes may be important for
understanding the way genes affect human behaviors and the way these behaviors
spread from person to person.Comment: Additional materials related to the paper are available at
http://jhfowler.ucsd.ed
Examining the benefits and harms of Alzheimer's disease screening for family members of older adults: study protocol for a randomized controlled trial
BACKGROUND:
Multiple national expert panels have identified early detection of Alzheimer's disease and related dementias (ADRD) as a national priority. However, the United States Preventive Services Task Force (USPSTF) does not currently support screening for ADRD in primary care given that the risks and benefits are unknown. The USPSTF stresses the need for research examining the impact of ADRD screening on family caregiver outcomes.
METHODS:
The Caregiver Outcomes of Alzheimer's Disease Screening (COADS) is a randomized controlled trial that will examine the potential benefits or harms of ADRD screening on family caregivers. It will also compare the effectiveness of two strategies for diagnostic evaluation and management after ADRD screening. COADS will enroll 1800 dyads who will be randomized into three groups (n = 600/group): the 'Screening Only' group will receive ADRD screening at baseline and disclosure of the screening results, with positive-screen participants receiving a list of local resources for diagnostic follow-up; the 'Screening Plus' group will receive ADRD screening at baseline coupled with disclosure of the screening results, with positive-screen participants referred to a dementia collaborative care program for diagnostic evaluation and potential care; and the control group will receive no screening. The COADS trial will measure the quality of life of the family member (the primary outcome) and family member mood, anxiety, preparedness and self-efficacy (the secondary outcomes) at baseline and at 6, 12, 18 and 24 months. Additionally, the trial will examine the congruence of depressive and anxiety symptoms between older adults and family members at 6, 12, 18 and 24 months and compare the effectiveness of two strategies for diagnostic evaluation and management after ADRD screening between the two groups randomized to screening (Screening Only versus Screening Plus).
DISCUSSION:
We hypothesize that caregivers in the screening arms will express higher levels of health-related quality of life, lower depressive and anxiety symptoms, and better preparation for caregiving with higher self-efficacy at 24 months. Results from this study will directly inform the National Plan to Address Alzheimer's Disease, the USPSTF and other organizations regarding ADRD screening and early detection policies
Adherence and Tolerability of Alzheimer's Disease Medications: A Pragmatic Randomized Trial
BACKGROUND/OBJECTIVES:
Post-marketing comparative trials describe medication use patterns in diverse, real-world populations. Our objective was to determine if differences in rates of adherence and tolerability exist among new users to acetylcholinesterase inhibitors (AChEI's).
DESIGN:
Pragmatic randomized, open label comparative trial of AChEI's currently available in the United States.
SETTING:
Four memory care practices within four healthcare systems in the greater Indianapolis area.
PARTICIPANTS:
Eligibility criteria included older adults with a diagnosis of possible or probable Alzheimer's disease (AD) who were initiating treatment with an AChEI. Participants were required to have a caregiver to complete assessments, access to a telephone, and be able to understand English. Exclusion criteria consisted of a prior severe adverse event from AChEIs.
INTERVENTION:
Participants were randomized to one of three AChEIs in a 1:1:1 ratio and followed for 18 weeks.
MEASUREMENTS:
Caregiver-reported adherence, defined as taking or not taking study medication, and caregiver-reported adverse events, defined as the presence of an adverse event.
RESULTS:
196 participants were included with 74.0% female, 30.6% African Americans, and 72.9% who completed at least twelfth grade. Discontinuation rates after 18 weeks were 38.8% for donepezil, 53.0% for galantamine, and 58.7% for rivastigmine (P = .063) in the intent to treat analysis. Adverse events and cost explained 73.1% and 25.4% of discontinuation. No participants discontinued donepezil due to cost. Adverse events were reported by 81.2% of all participants; no between-group differences in total adverse events were statistically significant.
CONCLUSIONS:
This pragmatic comparative trial showed high rates of adverse events and cost-related non-adherence with AChEIs. Interventions improving adherence and persistence to AChEIs may improve AD management.
TRIAL REGISTRATION:
Clinicaltrials.gov: NCT01362686 (https://clinicaltrials.gov/ct2/show/NCT01362686)
Layered architecture for quantum computing
We develop a layered quantum computer architecture, which is a systematic
framework for tackling the individual challenges of developing a quantum
computer while constructing a cohesive device design. We discuss many of the
prominent techniques for implementing circuit-model quantum computing and
introduce several new methods, with an emphasis on employing surface code
quantum error correction. In doing so, we propose a new quantum computer
architecture based on optical control of quantum dots. The timescales of
physical hardware operations and logical, error-corrected quantum gates differ
by several orders of magnitude. By dividing functionality into layers, we can
design and analyze subsystems independently, demonstrating the value of our
layered architectural approach. Using this concrete hardware platform, we
provide resource analysis for executing fault-tolerant quantum algorithms for
integer factoring and quantum simulation, finding that the quantum dot
architecture we study could solve such problems on the timescale of days.Comment: 27 pages, 20 figure
Effects of a Calcium Bentonite Clay in Diets Containing Aflatoxin when Measuring Liver Residues of Aflatoxin B1 in Starter Broiler Chicks
A long-term follow-up study investigating health-related quality of life and resource use in survivors of severe sepsis: comparison of recombinant human activated protein C with standard care
Observations of Non-radial Pulsations in Radio Pulsars
We introduce a model for pulsars in which non-radial oscillations of high
spherical degree (l) aligned to the magnetic axis of a spinning neutron star
reproduce the morphological features of pulsar beams. In our model, rotation of
the pulsar carries a pattern of pulsation nodes underneath our sightline,
reproducing the longitude stationary structure seen in average pulse profiles,
while the associated time-like oscillations reproduce "drifting
subpulses"--features that change their longitude between successive pulsar
spins. We will show that the presence of nodal lines can account for observed
180 degree phase jumps in drifting subpulses and their otherwise poor phase
stability, even if the time-like oscillations are strictly periodic. Our model
can also account for the "mode changes" and "nulls" observed in some pulsars as
quasiperiodic changes between pulsation modes of different l or radial overtone
n, analogous to pulsation mode changes observed in oscillating white dwarf
stars. We will discuss other definitive and testable requirements of our model
and show that they are qualitatively supported by existing data. While
reserving judgment until the completion of quantitative tests, we are inspired
enough by the existing observational support for our model to speculate about
the excitation mechanism of the non-radial pulsations, the physics we can learn
from them, and their relationship to the period evolution of pulsars.Comment: 28 pages, 9 figures (as separate png files), Astrophysical Journal,
in pres
Health-Related Quality of Life and Overall Life Satisfaction in People with Serious Mental Illness
Quality of life (QoL) in people with schizophrenia and other serious mental illnesses (SMI) is an important outcome goal, yet there is no consistent definition of the construct. We examined three aspects of QoL in persons with SMI: overall life satisfaction, physical health-related QoL (HRQoL), and mental HRQoL. This study had two primary aims: first, to examine whether there are differences in physical and mental HRQoL in persons with SMI, and, second, to investigate the cognitive, clinical, and functional correlates of the three QoL indicators. Participants were 48 persons with SMI who completed assessments of QoL, cognition, functional capacity, psychiatric symptomatology, and medical comorbidity. Results indicate that participants experience similar levels of physical and mental HRQoL, and these two constructs are not related to one another. Physical HRQoL is associated with less medical comorbidity, while mental HRQoL is associated with negative and depressive symptoms. Overall life satisfaction was associated with fewer psychiatric symptoms and less medical comorbidity. This study adds to the important literature defining distinct domains of QoL and supports the necessity of addressing both physical and mental health factors as they relate to recovery and well-being among persons with SMI
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