The Surprising Complexity of Virus-Host Cell Interaction Revealed by the Powerful Systems Biology Approaches of Genomics and Proteomics

Understanding interaction between viruses and host cells during infection process is the first step in discovering appropriate drugs and vaccines against viral diseases. Advance technologies based on genomics and proteomics approaches provide great tools to disclose the complexity of virus-host interaction. In this essay, the application of RNAi screens method and proteomics-based approaches on influenza virus will be elucidated as an example. Using those methods, the primary factors controlling viral replication pathway were discovered. These findings are useful for the development of potential strategies to overcome viral diseases