Student attitudes to entrepreneurship

This study on Student Attitudes to Entrepreneurship investigates the image which university students have of entrepreneurs and entrepreneurship. It is an initial exploratory/empirical study, which looks at the situation in Germany, Romania, Latvia, Italy and Austria. The study, based on questionnaires, shows that there are significant differences but also common features to the image of entrepreneurship and attitudes to it in the five countries. It is interesting to note that the students polled in connection with the study tended to have a neutral to positive/very positive image of entrepreneurs.attitude, attributes, entrepreneurs, entrepreneurship, opinion.

Large-Scale Screening: Phenotypic and Mutational Spectrum in Isolated and Combined Dystonia Genes

© 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.[Background] Pathogenic variants in several genes have been linked to genetic forms of isolated or combined dystonia. The phenotypic and genetic spectrum and the frequency of pathogenic variants in these genes have not yet been fully elucidated, neither in patients with dystonia nor with other, sometimes co-occurring movement disorders such as Parkinson's disease (PD).[Objectives] To screen >2000 patients with dystonia or PD for rare variants in known dystonia-causing genes.[Methods] We screened 1207 dystonia patients from Germany (DysTract consortium), Spain, and South Korea, and 1036 PD patients from Germany for pathogenic variants using a next-generation sequencing gene panel. The impact on DNA methylation of KMT2B variants was evaluated by analyzing the gene's characteristic episignature.[Results] We identified 171 carriers (109 with dystonia [9.0%]; 62 with PD [6.0%]) of 131 rare variants (minor allele frequency <0.005). A total of 52 patients (48 dystonia [4.0%]; four PD [0.4%, all with GCH1 variants]) carried 33 different (likely) pathogenic variants, of which 17 were not previously reported. Pathogenic biallelic variants in PRKRA were not found. Episignature analysis of 48 KMT2B variants revealed that only two of these should be considered (likely) pathogenic.[Conclusion] This study confirms pathogenic variants in GCH1, GNAL, KMT2B, SGCE, THAP1, and TOR1A as relevant causes in dystonia and expands the mutational spectrum. Of note, likely pathogenic variants only in GCH1 were also found among PD patients. For DYT-KMT2B, the recently described episignature served as a reliable readout to determine the functional effect of newly identified variants.This work was supported by the German Ministry of Education and Research (BMBF, DYSTRACT consortium, 01GM1514B, to A.A.K., T.B., C.Klein and K.L.) and the German Research Foundation (DFG, LO1555/10-1 to H.B., C.Klein, and K.L. and Project-ID 424778381-TRR 295 to A.A.K). The DysTract registry was further supported by the Arbeitskreis Botulinumtoxin der DGN e.V., Merz Therapeutics, AbbVie/Allergan, and Ipsen Pharma. The Korean DNA samples for this study were provided by the Seoul National University Hospital Human Biobank, a member of the National Biobank of Korea, which is supported by the Ministry of Health and Welfare. All samples derived from the National Biobank of Korea were obtained with informed consent under institutional review board-approved protocols. Several authors are members of the European Reference Network for Rare Neurological Diseases (Project ID No. 739510). Open Access funding enabled and organized by Projekt DEAL.Peer reviewe

Stakeholder collaboration in entrepreneurship education: an analysis of the entrepreneurial ecosystems of European higher educational institutions

Abstract Stakeholder theory has thus far received limited attention in the context of entrepreneurship education and university management. This paper addresses this research gap by examining the collaboration of stakeholders from the entrepreneurial ecosystem in entrepreneurship education at European higher educational institutions (HEIs). We contribute to existing research by combining literature streams from the ?elds of entrepreneurship education, entrepreneurial ecosystems and stakeholder theory. Empirical research is based on a cross-case analysis of 20 HEIs from 19 different European countries. Data sources include next to secondary data and observation a total 216 interviews with entrepreneurship education stakeholders at these 20 HEIs. The results of the case studies are further validated through an independent peer group and through 14 interviews with international experts in entrepreneurship education. Based on this data, an overview of the key external stakeholder groups of the entrepreneurial ecosystem of HEIs and their forms of involvement in entrepreneurship education is provided. Furthermore, the strength and coordination of stakeholder collaboration and the overall approaches to stakeholder management are discussed. This analysis results in the development of a set of propositions on stakeholder involvement in the context of entrepreneurship education at HEIs. The ?ndings of this paper highlight the importance of stakeholder collaboration from th

Stakeholder collaboration in entrepreneurship education: an analysis of the entrepreneurial ecosystems of European higher educational institutions

Abstract Stakeholder theory has thus far received limited attention in the context of entrepreneurship education and university management. This paper addresses this research gap by examining the collaboration of stakeholders from the entrepreneurial ecosystem in entrepreneurship education at European higher educational institutions (HEIs). We contribute to existing research by combining literature streams from the ?elds of entrepreneurship education, entrepreneurial ecosystems and stakeholder theory. Empirical research is based on a cross-case analysis of 20 HEIs from 19 different European countries. Data sources include next to secondary data and observation a total 216 interviews with entrepreneurship education stakeholders at these 20 HEIs. The results of the case studies are further validated through an independent peer group and through 14 interviews with international experts in entrepreneurship education. Based on this data, an overview of the key external stakeholder groups of the entrepreneurial ecosystem of HEIs and their forms of involvement in entrepreneurship education is provided. Furthermore, the strength and coordination of stakeholder collaboration and the overall approaches to stakeholder management are discussed. This analysis results in the development of a set of propositions on stakeholder involvement in the context of entrepreneurship education at HEIs. The ?ndings of this paper highlight the importance of stakeholder collaboration from th

Multinational companies’ strategies for R&amp;D internationalization:Emerging versus advanced economies

Empirical studies and theory development on firm internationalization have been mostly focused on advanced-economy multinational companies (AMNCs). In recent years, however, emerging economies’ multinational companies (EMNCs) have been on the rise with respect to their presence and investment in foreign markets. Technology- and innovation-driven investments by EMNCs are a new trend allowing them to build up their innovation capabilities and, hence, to catch-up with AMNCs. We analyze knowledge-related strategies within EMNCs versus AMNCs R&amp;D internationalization. In line with theoretical predictions, our empirical findings based on a large multinational dataset show that EMNCs compared to AMNCs are more like to follow a knowledge exploration strategy and less likely to follow a knowledge exploitation strategy. Moreover, we show that technological leadership constitutes an important firm-level contingency, which leverages EMNCs’ knowledge exploitation. Consequently, R&amp;D internationalization by technological leaders from emerging economies follows knowledge-related strategies mirroring those by AMNC

Die Rolle des Cultural Entrepreneurs in einer nachhaltigen Gestaltung des Kultursektors

Ausgehend von dem Unternehmerbegriff nach Schumpeter befasst sich dieser Beitrag in einer theoretisch-konzeptionellen Perspektive mit Charakteristika, Verhaltensweisen und Kompetenzen des Cultural Entrepreneurs. Ein Ergebnis ist die Generierung eines Kompetenzprofils, das aus dem Dreiklang Entrepreneur, Künstler und Kulturvermittler besteht. In einer Nachhaltigkeitsbetrachtung wurden im Kontext des Wandels und des Bewahrens von Kultur mögliche Spannungsfelder beleuchtet. Dabei wurde gezeigt, dass der Cultural Entrepreneur aufgrund seiner unternehmerischen Kompetenzen eine Schlüsselrolle im Auflösen der Spannungsfelder der Nachhaltigkeit spielen kann, indem er durch sein innovatives Handeln veraltete Strukturen aufzulösen vermag und ein neues Zusammenspiel zwischen den Akteuren bewirken kann