Os Mamíferos dos Canaviais de Quirinópolis, Cachoeira Dourada, Itumbiara e Goiatuba, Goiás, Brasil

Resumo: o agro-ecossistema formado pelo cultivo da cana-de-açúcar pode apresentar uma considerável riqueza de espécies da mastofauna. O conjunto de técnicas utilizadas no esforço de amostragem em canaviais nos municípios de Quirinópolis, Cachoeira Dourada, Itumbiara e Goiatuba, forneceu uma riqueza de 40 espécies representantes de 20 famílias, distribuídas em 10 ordens. Palavras-chave: Mastofauna. Canaviais. Goiás

Island Schools : Sustainable Tourism Teacher Pack

This teacher pack is designed to support Island School teachers who are embarking on the first year of the Island School Educational Programme together with their pupils. How the programme works as a whole is explained in more detail below. The teacher pack provides lesson or ‘session’ plans, which can be used as flexibly as you’d like. Feel free to make use of the materials in the ‘additional materials’ section of the pack or integrate your own materials. Take as long or short as you like to follow the programme in coordination with your partner school. And most importantly: have fun and follow the pupils’ curiosity

Island Schools: Policy Briefings for Island Schools : Based on the stakeholder meeting results of all project partners

The Island Schools project provides policy recommendations on the future of sustainable education on Europe's islands. A key part of this comes from pupils of Island Schools themselves, using a technique called 'backcasting' to come up with solutions for the sustainable future of their islands and the important role of schools and young people in realising it

Island Schools : Ocean Plastics Teacher Pack

This teacher pack is designed to support Island School teachers who are embarking on the first year of the Island School Educational Programme together with their pupils. How the programme works as a whole is explained in more detail below. The teacher pack provides lesson or ‘session’ plans, which can be used as flexibly as you’d like. Feel free to make use of the materials in the ‘additional materials’ section of the pack or integrate your own materials. Take as long or short as you like to follow the programme in coordination with your partner school. And most importantly: have fun and follow the pupils’ curiosity

Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression

Hypoxia is an environmental cue that is associated with multiple tumorigenic processes such as immunosuppression, angiogenesis, cancer invasion, metastasis, drug resistance, and poor clinical outcomes. When facing hypoxic stress, cells initiate several adaptive responses such as cell cycle arrest to reduce excessive oxygen consumption and co-activation of oncogenic factors. In order to identify the critical novel proteins for hypoxia responses, we used pulsed-SILAC method to trace the active cellular translation events in A431 cells. Proteomic discovery data and biochemical assays showed that cancer cells selectively activate key glycolytic enzymes and novel ER-stress markers, while protein synthesis is severely suppressed. Interestingly, deprivation of oxygen affected the expression of various epigenetic regulators such as histone demethylases and NuRD (nucleosome remodeling and deacetylase) complex in A431 cells. In addition, we identified PHF14 (the plant homeodomain finger-14) as a novel hypoxia-sensitive epigenetic regulator that plays a key role in cell cycle progress and protein synthesis. Hypoxia-mediated inhibition of PHF14 was associated with increase of key cell cycle inhibitors, p14ARF, p15INK4b, and p16INK4a, which are responsible for G1-S phase transition and decrease of AKT-mTOR-4E-BP1/pS6K signaling pathway, a master regulator of protein synthesis, in response to environmental cues. Analysis of TCGA colon cancer (n=461) and skin cancer (n=470) datasets revealed a positive correlation between PHF14 expression and protein translation initiation factors, eIF4E, eIF4B, and RPS6. Significance of PHF14 gene was further demonstrated by in vivo mouse xenograft model using PHF14 KD cell lines.Ministry of Education (MOE)National Medical Research Council (NMRC)Published versionThis study was supported by the Singapore Ministry of Education (MOE2014-T2-2-043, MOE2016-T2-2-018 and MOE2016-T3-1-003) and the National Medical Research Council of Singapore (NMRC-OF-IRG-0003-2016)