Exploring the Lived Experience of Conscientious Objection for Registered Nurses in Ontario.

Nursing is an ethical profession in which nurses are called to act ethically, be moral agents and function with moral integrity. Contemporary nursing practice is morally pluralistic and at times, nurses may be faced with a conflict of conscience that motivates them to voice their ethical concerns about patient care provision that they perceive to be unethical. This concern can result in the format of a conscientious objection. Conscientious objection involves an individual objecting to doing something they deem unethical and to refrain from participating in that unethical action. The aim of the question guiding this research study was to gain an in-depth understanding of what it means to be a nurse voicing a conscientious objection in workplace settings. An interpretive phenomenological approach was used to gain a deeper awareness of nurses’ ethical experiences through one-on-one, semi-structured interviews with registered nurses practicing across health care settings in Ontario. Data analysis was conducted consistent with thematic analysis of the participant’s narratives. Themes that arose around nurses’ meaningful experiences with voicing a conscientious objection include: encountering the problem, knowing oneself, taking a stand, alone and uncertainty, caring for others and perceptions of support. The findings inform health professionals of the intricacies of making a conscientious objection for nurses. It is anticipated that such insight will generate further support for nurses addressing ethical dilemmas in professional practice. Implications and recommendations for nursing practice, policy, nursing education and further research are discussed

Identification of bacterial isolates recovered from the surface of cleanroom operators' garments following wear.

Contamination of sterile pharmaceutical products can have serious consequences, in worst case scenario resulting in patient death. Cleanroom operators are the primary source of microbial contamination, where the surface of their specialist sterile clothing garments is subject to such contamination during wear. In turn these garments become a transmission vector for microorganisms within the cleanroom environment. Insight into identification of predominant bacterial isolates from garment surfaces would help to establish their original source and probable contamination route. This should assist possible intervention strategies to mitigate against this contamination. The research aimed to determine identity of representative bacterial isolates recovered from the surface of cleanroom operators' garments following wear within a cleanroom. Following isolation and purification of bacterial isolates, 16S rRNA gene sequencing was used to establish species identity for isolates recovered from the surface of male and female operators' garments following wear within the cleanroom environment. Of the 47 isolates recovered from the surface of garments, 16S rRNA gene sequencing successfully identified 94% to genus level and 77% to species level. Most were confirmed as Gram - positive bacteria; predominantly species of Staphylococcus, Micrococcus and Bacillus. The isolates recovered from the surface of female operatives' garments were more diverse than those retrieved from male counterparts. Most isolates recovered from garments were found to be skin commensals, with nearly 70% attributed to the operators within the environment. The remainder were credited to contamination of garments with species of environmental origin. Whilst most bacteria identified present minimal threat to healthy individuals, certain of these are opportunistic pathogens, presenting a hazard for immunocompromised and/or those with underlying health conditions

What advances may the future bring to the diagnosis, treatment, and care of male sexual and reproductive health?

Over the past 40 years, since the publication of the original WHO Laboratory Manual for the Examination and Processing of Human Semen, the laboratory methods used to evaluate semen markedly changed and benefited from improved precision and accuracy, as well as the development of new tests and improved, standardized methodologies. Herein, we present the impact of the changes put forth in the sixth edition together with our views of evolving technologies that may change the methods used for the routine semen analysis, up-and-coming areas for the development of new procedures, and diagnostic approaches that will help to extend the often-descriptive interpretations of several commonly performed semen tests that promise to provide etiologies for the abnormal semen parameters observed. As we look toward the publication of the seventh edition of the manual in approximately 10 years, we describe potential advances that could markedly impact the field of andrology in the future

Advanced Hyperspectral Analysis of Sediment Core Samples from the Chew Bahir Basin, Ethiopian Rift, in the Spectral Range from 0.25 to 17 µm:Support for Climate Proxy Interpretation

Establishing robust environmental proxies at newly investigated terrestrial sedimentary archives is a challenge, because straightforward climate reconstructions can be hampered by the complex relationship between climate parameters and sediment composition, proxy preservation or (in)sufficient sample material. We present a minimally invasive hyperspectral bidirectional reflectance analysis on discrete samples in the wavelength range from 0.25 to 17 mu m on 35 lacustrine sediment core samples from the Chew Bahir Basin, southern Ethiopia for climate proxy studies. We identified and used absorption bands at 2.2 mu m (Al-OH), at 2.3 mu m (Mg-OH), at 1.16 mu m (analcime), and at 3.98 mu m (calcite) for quantitative spectral analysis. The band depth ratios at 2.3/2.2 mu m in the spectra correlate with variations in the potassium content of the sediment samples, which also reflect periods of increased Al-to-Mg substitution in clay minerals during drier climatic episodes. During these episodes of drier conditions, absorption bands diagnostic of the presence of analcime and calcite support this interpretation, with analcime indicating the driest conditions. These results could be compared to qualitative analysis of other characteristic spectral properties in the spectral range between 0.25 and 17 mu m. The results of the hyperspectral measurements complement previous sedimentological and geochemical analyses, allowing us in particular to resolve more finely the processes of weathering in the catchment and low-temperature authigenic processes in the sediment. This enables us to better understand environmental changes in the habitat of early humans

Bibliometric analysis of authorship trends and collaboration dynamics over the past three decades of BONE's publication history

The existence of a gender gap in academia has been a hotly debated topic over the past several decades. It has been argued that due to the gender gap, it is more difficult for women to obtain higher positions. Manuscripts serve as an important measurement of one's accomplishments within a particular field of academia. Here, we analyzed, over the past 3 decades, authorship and other trends in manuscripts published in BONE, one of the premier journals in the field of bone and mineral metabolism. For this study, one complete year of manuscripts was evaluated (e.g. 1985, 1995, 2005, 2015) for each decade. A bibliometric analysis was then performed of authorship trends for those manuscripts. Analyzed fields included: average number of authors per manuscript, numerical position of the corresponding author, number of institutions collaborating on each manuscript, number of countries involved with each manuscript, number of references, and number of citations per manuscript. Each of these fields increased significantly over the 30-year time frame (p < 10− 6). The gender of both the first and corresponding authors was identified and analyzed over time and by region. There was a significant increase in the percentage of female first authors from 23.4% in 1985 to 47.8% in 2015 (p = 0.001). The percentage of female corresponding authors also increased from 21.2% in 1985 to 35.4% in 2015 although it was not significant (p = 0.07). With such a substantial emphasis being placed on publishing in academic medicine, it is crucial to comprehend the changes in publishing characteristics over time and geographical region. These findings highlight authorship trends in BONE over time as well as by region. Importantly, these findings also highlight where challenges still exist

Advanced Hyperspectral Analysis of Sediment Core Samples from the Chew Bahir Basin, Ethiopian Rift, in the Spectral Range from 0.25 to 17 µm: Support for Climate Proxy Interpretation

Establishing robust environmental proxies at newly investigated terrestrial sedimentary archives is a challenge, because straightforward climate reconstructions can be hampered by the complex relationship between climate parameters and sediment composition, proxy preservation or (in)sufficient sample material. We present a minimally invasive hyperspectral bidirectional reflectance analysis on discrete samples in the wavelength range from 0.25 to 17 µm on 35 lacustrine sediment core samples from the Chew Bahir Basin, southern Ethiopia for climate proxy studies. We identified and used absorption bands at 2.2 μm (Al–OH), at 2.3 μm (Mg–OH), at 1.16 μm (analcime), and at 3.98 μm (calcite) for quantitative spectral analysis. The band depth ratios at 2.3/2.2 μm in the spectra correlate with variations in the potassium content of the sediment samples, which also reflect periods of increased Al-to-Mg substitution in clay minerals during drier climatic episodes. During these episodes of drier conditions, absorption bands diagnostic of the presence of analcime and calcite support this interpretation, with analcime indicating the driest conditions. These results could be compared to qualitative analysis of other characteristic spectral properties in the spectral range between 0.25 and 17 µm. The results of the hyperspectral measurements complement previous sedimentological and geochemical analyses, allowing us in particular to resolve more finely the processes of weathering in the catchment and low-temperature authigenic processes in the sediment. This enables us to better understand environmental changes in the habitat of early humans

Overt and Latent Cardiac Effects of Ozone Inhalation in Rats: Evidence for Autonomic Modulation and Increased Myocardial Vulnerability

Background: Ozone (O3) is a well-documented respiratory oxidant, but increasing epidemiological evidence points to extrapulmonary effects, including positive associations between ambient O3 concentrations and cardiovascular morbidity and mortality