Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing

The RD53 Collaboration's SystemVerilog-UVM Simulation Framework and its General Applicability to Design of Advanced Pixel Readout Chips

The foreseen Phase 2 pixel upgrades at the LHC have very challenging requirements for the design of hybrid pixel readout chips. A versatile pixel simulation platform is as an essential development tool for the design, verification and optimization of both the system architecture and the pixel chip building blocks (Intellectual Properties, IPs). This work is focused on the implemented simulation and verification environment named VEPIX53, built using the SystemVerilog language and the Universal Verification Methodology (UVM) class library in the framework of the RD53 Collaboration. The environment supports pixel chips at different levels of description: its reusable components feature the generation of different classes of parameterized input hits to the pixel matrix, monitoring of pixel chip inputs and outputs, conformity checks between predicted and actual outputs and collection of statistics on system performance. The environment has been tested performing a study of shared architectures of the trigger latency buffering section of pixel chips. A fully shared architecture and a distributed one have been described at behavioral level and simulated; the resulting memory occupancy statistics and hit loss rates have subsequently been compared.Comment: 15 pages, 10 figures (11 figure files), submitted to Journal of Instrumentatio

Preliminary evaluation of radar imagery of Yellowstone Park, Wyoming

Evaluation of radar imagery of Yellowstone Park, Wyomin

IADC Vulnerability Report, IT32-21

Numerous mission support hardware systems and their spares are maintained outside of the habitable volume of the International Space Station (ISS), and are arranged covered by a multi-layer insulation (MLI) thermal blanket which provides both thermal control and a measure of protection from micrometeoroids and orbital debris (MMOD). The NASA Hypervelocity Impact Technology (HVIT) group at the Johnson Space Center in Houston Texas has assessed the protection provided by MLI in a series of hypervelocity impact tests using a 1 mm thick aluminum 6061-T6 rear wall to simulate the actual hardware behind the MLI. HVIT has also evaluated methods to enhance the protection provided by MLI thermal blankets. The impact study used both aluminum and steel spherical projectiles accelerated to speeds of 7 km/s using a 4.3 mm, two-stage, light-gas gun at the NASA White Sands Test Facility (WSTF)

STS-114 Micrometeoroid/Orbital Debris (MMOD) Post-Flight Assessment

NASA Johnson Space Center (JSC) personnel assisted Kennedy Space Center (KSC) inspection teams in the identification of 41 micrometeoroid/orbital debris (MMOD) impact sites on the OV-103 vehicle (Discovery) during STS-114 postflight inspections. There were 14 MMOD impacts reported on the crew module windows (Figure 1). The largest impact feature, a 6.6 mm x 5.8 mm crater on window #4, was caused by a particle with an estimated diameter of 0.22 mm (Figure 2). This impact was among the largest ever recorded on a crew module window. The window was removed and replaced. Scanning Electron Microscope/Energy Dispersive X-ray (SEM/EDX) analysis of dental mold samples from the impact site to determine particle origin was inconclusive, possibly due to contamination picked up on the ferry flight from Edwards Air Force Base to KSC. The radiators on the inside of the payload bay doors sustained 19 impacts (Figure 3) with one of the impacts causing a face sheet perforation. The 0.61 mm diameter hole was produced by a particle with an estimated diameter of 0.4 mm, which approaches the 0.5-mm critical particle diameter of the wing leading edge reinforced carbon-carbon (RCC) panel high-temperature regions (Zone 3, Figure 4) that was established during Return to Flight testing of the RCC panels. An inspection of the payload bay door exterior insulation (FRSI) revealed a 5.8 mm x 4.5 mm defect that was caused by an MMOD particle with unknown composition, as the sample obtained was contaminated. Figure 5 provides a summary of the exterior surface survey that was conducted following the STS-114 mission. Two windows were removed and replaced due to hypervelocity impact. Nineteen impacts were recorded on the payload bay door radiators, with one face sheet penetration. Three impact sites were identified on the FRSI. There were four hypervelocity impact sites detected on the wing leading edge RCC panels. One impact was detected on the top cover of the TPS sample box (TSB) payload that was mounted on a carrier in the aft portion of the payload bay

Analytic Ballistic Performance Model of Whipple Shields

The dual-wall, Whipple shield is the shield of choice for lightweight, long-duration flight. The shield uses an initial sacrificial wall to initiate fragmentation and melt an impacting threat that expands over a void before hitting a subsequent shield wall of a critical component. The key parameters to this type of shield are the rear wall and its mass which stops the debris, as well as the minimum shock wave strength generated by the threat particle impact of the sacrificial wall and the amount of room that is available for expansion. Ensuring the shock wave strength is sufficiently high to achieve large scale fragmentation/melt of the threat particle enables the expansion of the threat and reduces the momentum flux of the debris on the rear wall. Three key factors in the shock wave strength achieved are the thickness of the sacrificial wall relative to the characteristic dimension of the impacting particle, the density and material cohesion contrast of the sacrificial wall relative to the threat particle and the impact speed. The mass of the rear wall and the sacrificial wall are desirable to minimize for launch costs making it important to have an understanding of the effects of density contrast and impact speed. An analytic model is developed here, to describe the influence of these three key factors. In addition this paper develops a description of a fourth key parameter related to fragmentation and its role in establishing the onset of projectile expansion

IADC Vulnerability Report, IT32-13

This section provides hypervelocity impact test data for two types of batteries: Lithium-Ion (Li-Ion) and Nickel Hydrogen (Ni-H2) batteries. The impact tests were directed by the NASA Johnson Space Center Hypervelocity Impact Technology (HVIT) group in Houston Texas, and were performed at the NASA White Sands Test Facility (WSTF)

Ballistic Performance Model of Crater Formation in Monolithic, Porous Thermal Protection Systems

Porous monolithic ablative systems insulate atmospheric reentry vehicles from reentry plasmas generated by atmospheric braking from orbital and exo-orbital velocities. Due to the necessity that these materials create a temperature gradient up to several thousand Kelvin over their thickness, it is important that these materials are near their pristine state prior to reentry. These materials may also be on exposed surfaces to space environment threats like orbital debris and meteoroids leaving a probability that these exposed surfaces will be below their prescribed values. Owing to the typical small size of impact craters in these materials, the local flow fields over these craters and the ablative process afford some margin in thermal protection designs for these locally reduced performance values. In this work, tests to develop ballistic performance models for thermal protection materials typical of those being used on Orion are discussed. A density profile as a function of depth of a typical monolithic ablator and substructure system is shown in Figure 1a

Probabilistic Weyl laws for quantized tori

For the Toeplitz quantization of complex-valued functions on a $2n$-dimensional torus we prove that the expected number of eigenvalues of small random perturbations of a quantized observable satisfies a natural Weyl law. In numerical experiments the same Weyl law also holds for ``false'' eigenvalues created by pseudospectral effects.Comment: 33 pages, 3 figures, v2 corrected listed titl

Gluon distributions in nucleons and pions at a low resolution scale

In this paper we study the gluon distribution functions in nucleons and pions at a low resolution $Q^2$ scale. This is an important issue since parton densities at low $Q^2$ have always been taken as an external input which is adjusted through DGLAP evolution to fit the experimental data at higher scales. Here, in the framework of a model recently developed, it is shown that the hypothetical cloud of {\it neutral} pions surrounding nucleons and pions appears to be responsible for the characteristic valence-like gluon distributions needed at the inital low scale. As an additional result, we get the remarkable prediction that neutral and charged pions have different intrinsic sea flavor contents.Comment: final version to appear in Phys. Rev. D. Discussion on several points enlarge