Feynman integral relations from parametric annihilators

We study shift relations between Feynman integrals via the Mellin transform through parametric annihilation operators. These contain the momentum space IBP relations, which are well-known in the physics literature. Applying a result of Loeser and Sabbah, we conclude that the number of master integrals is computed by the Euler characteristic of the Lee-Pomeransky polynomial. We illustrate techniques to compute this Euler characteristic in various examples and compare it with numbers of master integrals obtained in previous works.Comment: v2: new section 3.1 added, several misprints corrected and additional remark

Linking an Early Triassic delta to antecedent topography: Source-to-sink study of the southwestern Barents Sea margin

Present-day catchments adjacent to sedimentary basins may preserve geomorphic elements that have been active through long intervals of time. Relicts of ancient catchments in present-day landscapes may be investigated using mass-balance models and can give important information about upland landscape evolution and reservoir distribution in adjacent basins. However, such methods are in their infancy and are often difficult to apply in deep-time settings due to later landscape modification. The southern Barents Sea margin of N Norway and NW Russia is ideal for investigating source-to-sink models, because it has been subject to minor tectonic activity since the Carboniferous, and large parts have eluded significant Quaternary glacial erosion. A zone close to the present-day coast has likely acted as the boundary between basin and catchments since the Carboniferous. Around the Permian-Triassic transition, a large delta system started to prograde from the same area as the present-day largest river in the area, the Tana River, which has long been interpreted to show features indicating that it was developed prior to present-day topography. We performed a source-to-sink study of this ancient system in order to investigate potential linkages between present-day geomorphology and ancient deposits. We investigated the sediment load of the ancient delta using well, core, two-dimensional and three-dimensional seismic data, and digital elevation models to investigate the geomorphology of the onshore catchment and surrounding areas. Our results imply that the present-day Tana catchment was formed close to the Permian-Triassic transition, and that the Triassic delta system has much better reservoir properties compared to the rest of Triassic basin infill. This implies that landscapes may indeed preserve catchment geometries for extended periods of time, and it demonstrates that source-to-sink techniques can be instrumental in predicting the extent and quality of subsurface reservoirs.publishedVersio

Linking sediment supply variations and tectonic evolution in deep time, source-to-sink systems—The Triassic Greater Barents Sea Basin

Triassic strata in the Greater Barents Sea Basin are important records of geodynamic activity in the surrounding catchments and sediment transport in the Arctic basins. This study is the first attempt to investigate the evolution of these source areas through time. Our analysis of sediment budgets from subsurface data in the Greater Barents Sea Basin and application of the BQART approach to estimate catchment properties shows that (1) during the Lower Triassic, sediment supply was at its peak in the basin and comparable to that of the biggest modern-day river systems, which are supplied by tectonically active orogens; (2) the Middle Triassic sediment load was significantly lower but still comparable to that of the top 10 largest modern rivers; (3) during the Upper Triassic, sediment load increased again in the Carnian; and (4) there is a large mismatch (70%) between the modeled and estimated sediment load of the Carnian. These results are consistent with the Triassic Greater Barents Sea Basin succession being deposited under the influence of the largest volcanic event ever at the Permian-Triassic boundary (Siberian Traps) and concurrent with the climatic changes of the Carnian Pluvial Event and the final stages of the Northern Ural orogeny. They also provide a better understanding of geodynamic impacts on sedimentary systems and improve our knowledge of continental-scale sediment transport. Finally, the study demonstrates bypass of sediment from the Ural Mountains and West Siberia into the adjacent Arctic Sverdrup, Chukotka, and Alaska Basins in Late Carnian and Late Norian time.publishedVersio

Linking regional unconformities in the Barents Sea to compression-induced forebulge uplift at the Triassic-Jurassic transition

The Triassic-Jurassic transition marks an important change in the basin configuration of the Greater Barents Sea. A contiguous basin with km-thick sedimentary successions changed into a partitioned basin with uplift in the west and foreland basins in the east with significant implication for the basin infill history. Our study employs a range of different high-resolution datasets from a distal part of the basin which unravels the complex pattern of differential uplift and erosion in the basin during this period. We record for the first time distinct angular unconformities between Upper Triassic strata and overlying Lower Jurassic strata within the basin, showing that large parts of it formed topographic highs. Our study links these angular unconformities to compression induced by the Novaya Zemlya Fold and Thrust Belt. A heterolithic basement below a thick sedimentary succession where the fold belt developed created a complex uplift pattern in the basin, at the same time similar to but different from typical forebulge areas. Compression caused inversion of older basement rooted faults defining platforms and graben systems throughout western parts of the Barents Sea basin, in addition to salt remobilization that resulted in differential uplift and erosion. These local zones of uplift controlled the sediment distribution pattern to the basin at a time when the most important reservoir units in the basin were deposited. This new understanding of the basin development explains hitherto enigmatic sequence boundaries that has inspired complex paleogeographic models in the past.publishedVersio

A randomized placebo-controlled phase II study of clarithromycin or placebo combined with VCD induction therapy prior to high-dose melphalan with stem cell support in patients with newly diagnosed multiple myeloma

Abstract Background The objective of this randomized placebo-controlled study was to investigate the efficacy and safety of clarithromycin in combination with bortezomib–cyclophosphamide–dexamethasone (VCD) in patients with newly diagnosed multiple myeloma eligible for high-dose therapy. Methods Patients were randomized to receive tablet clarithromycin 500 mg or matching placebo tablet twice daily during the first 3 cycles of VCD induction therapy. Primary endpoint was to compare the rate of very good partial response (VGPR) or better response after three cycles of VCD combined with clarithromycin or placebo. Results The study was prematurely stopped for safety reasons after the inclusion of 58 patients (36% of the planned study population). The patients were randomly assigned to clarithromycin (n = 27) or placebo (n = 31). VGPR or better response after the VCD induction therapy was obtained in 12 patients (44.4%, 95% CI 25.5–64.7) and in 16 patients (51.6%, 33.1–69.8) (p = 0.59) in the clarithromycin group and the placebo group, respectively. Seven patients (25.9%) in the clarithromycin group developed severe gastrointestinal complications (≥ grade 3) comprising pain, neutropenic enterocolitis, paralytic ileus or peptic ulcer. These complications occurred in only one patient in the placebo group. Septicemia with Gram negative bacteria was observed in 5 patients in the clarithromycin group in contrast to one case of pneumococcal septicemia in the placebo group. Patient-reported QoL were negatively affected in the clarithromycin group compared to the placebo group. Conclusion The study was prematurely stopped due to serious adverse events, in particular serious gastrointestinal complications and septicemia. The response data do not suggest any effect of clarithromycin when added to the VCD regimen. The combination of clarithromycin and bortezomib containing regimens is toxic and do not seem to offer extra anti-myeloma efficacy. Trial registration EudraCT (no. 2014-002187-32, registered 7 October 2014, https://www.clinicaltrialsregister.eu/ctr-search/trial/2014-002187-32/DK) and ClinicalTrials.gov (no NCT02573935, retrospectively registered 12 October 2015, https://www.clinicaltrials.gov/ct2/show/NCT02573935?term=Gregersen&cntry=DK&rank=9

Carfilzomib and dexamethasone maintenance following salvage ASCT in multiple myeloma: A randomised phase 2 trial by the Nordic Myeloma Study Group

Objective: We investigated the efficacy and safety of carfilzomib-containing induction before salvage high-dose melphalan with autologous stem-cell transplantation (salvage ASCT) and maintenance with carfilzomib and dexamethasone after salvage ASCT in multiple myeloma.Methods: This randomised, open-label, phase 2 trial included patients with first relapse of multiple myeloma after upfront ASCT who were re-induced with four cycles of carfilzomib, cyclophosphamide and dexamethasone. Two months after salvage, ASCT patients were randomised to either observation or maintenance therapy with iv carfilzomib 27 -> 56 mg/sqm and p.o. dexamethasone 20 mg every second week. The study enrolled 200 patients of which 168 were randomised to either maintenance with carfilzomib and dexamethasone (n = 82) or observation (n = 86).Results: Median time to progression (TTP) after randomisation was 25.1 months (22.5-NR) in the carfilzomib-dexamethasone maintenance group and 16.7 months (14.4-21.8) in the control group (HR 0.46, 95% CI 0.30-0.71; P = .0004). The most common adverse events during maintenance were thrombocytopenia, anaemia, hypertension, dyspnoea and bacterial infections.Conclusion: In summary, maintenance therapy with carfilzomib and dexamethasone after salvage ASCT prolonged TTP with 8 months. The maintenance treatment was in general well-tolerated with manageable toxicity.</p