1,931 research outputs found

    Lack of Effect of Metyrapone and Exogenous Cortisol on Early Porcine Conceptus Development

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    In many species, including swine, fetal plasma glucocorticoids such as cortisol increase as term approaches and are responsible for final maturational changes in numerous tissues (e.g. Silver, 1990; Sangild et al. 1993, 1994; Fowden et al. 1995). On the contrary, excessive exposure to glucocorticoids during gestationmay cause intra-uterine growth retardation, developmental abnormalities or death, or lead to increased incidence of certain diseases during adult life (Blackburn et al. 1965; Reinisch et al. 1978; Seckl et al. 2000). Hence, one might speculate that a closely regulated glucocorticoid exposure is necessary throughout gestation to ensure appropriate development and survival (Klemcke et al. 1999). We have previously demonstrated in pregnant and cyclic pigs that intra-uterine cortisol increases 4- to 6.7-fold between days 10 and 19 of pregnancy (Klemcke et al. 1998). At this time (days 10–19) in conceptus (embryo plus associated extra-embryonic membranes) development, the blastocyst is undergoing quite dramatic changes (Marrable, 1971; Anderson, 1978; Anderson et al. 1993). Part of this development involves the allantois, which rapidly expands between days 18 and 30 owing to water accumulation (Bazer et al. 1981) that might in part result from Na+,K+-ATPase-generated water movement (Macknight & Leaf, 1977). Corticosteroids are known to regulate Na+,K+-ATPase in various tissues (e.g. Verrey et al. 1996)

    Lack of Effect of Metyrapone and Exogenous Cortisol on Early Porcine Conceptus Development

    Get PDF
    In many species, including swine, fetal plasma glucocorticoids such as cortisol increase as term approaches and are responsible for final maturational changes in numerous tissues (e.g. Silver, 1990; Sangild et al. 1993, 1994; Fowden et al. 1995). On the contrary, excessive exposure to glucocorticoids during gestationmay cause intra-uterine growth retardation, developmental abnormalities or death, or lead to increased incidence of certain diseases during adult life (Blackburn et al. 1965; Reinisch et al. 1978; Seckl et al. 2000). Hence, one might speculate that a closely regulated glucocorticoid exposure is necessary throughout gestation to ensure appropriate development and survival (Klemcke et al. 1999). We have previously demonstrated in pregnant and cyclic pigs that intra-uterine cortisol increases 4- to 6.7-fold between days 10 and 19 of pregnancy (Klemcke et al. 1998). At this time (days 10–19) in conceptus (embryo plus associated extra-embryonic membranes) development, the blastocyst is undergoing quite dramatic changes (Marrable, 1971; Anderson, 1978; Anderson et al. 1993). Part of this development involves the allantois, which rapidly expands between days 18 and 30 owing to water accumulation (Bazer et al. 1981) that might in part result from Na+,K+-ATPase-generated water movement (Macknight & Leaf, 1977). Corticosteroids are known to regulate Na+,K+-ATPase in various tissues (e.g. Verrey et al. 1996)

    Identification of Quantitative Trait Loci Affecting Female Reproductive Traits in a Multigeneration Meishan-White Composite Swine Population

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    A multigeneration crossbred Meishan- White composite resource population was used to identify quantitative trait loci (QTL) for age at first estrus (AP) and the components of litter size: ovulation rate (OR; number of ova released in an estrous period) and uterine capacity (UC). The population was established by reciprocally mating Meishan (ME) and White composite (WC) pigs. Resultant F1 females were mated to either ME or WC boars to produce backcross progeny (BC) of either ¾ WC ¼ ME or ¼ WC ¾ ME. To produce the next generation (F3) , ¾ WC ¼ ME animals were mated to ¼ WC ¾ ME animals yielding half-blood (½ WC ½ ME) progeny. A final generation (F4) was produced by inter se mating F3 animals. Measurements for AP and OR were recorded on 101 BC, 389 F3, and 110 F4 gilts, and UC data were from 101 BC and 110 F4 first parity litters. A genomic scan was conducted with markers (n = 157) spaced &#;20 cM apart. All parental, F1, BC, and F4 animals but only 84 F3 animals were genotyped and included in this study. The QTL analysis fitted a QTL at 1-cM intervals throughout the genome, and QTL effects were tested using approximate genome-wide significance levels. For OR, a significant (E[false positive] \u3c .05) QTL was detected on chromosome 8, suggestive (E[false positive] \u3c 1.0) QTL were detected on chromosomes 3 and 10, and two additional regions were detected that may possess a QTL (E[false positive] \u3c 2.0) on chromosomes 9 and 15. Two regions possessed suggestive evidence for QTL affecting AP on chromosomes 1 and 10, and one suggestive region on chromosome 8 was identified for UC. Further analyses of other populations of swine are necessary to determine the extent of allelic variation at the identified QTL

    Thermally Activated Dynamics of the Capillary Condensation

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    This paper is devoted to the thermally activated dynamics of the capillary condensation. We present a simple model which enables us to identify the critical nucleus involved in the transition mechanism. This simple model is then applied to calculate the nucleation barrier from which we can obtain informations on the nucleation time. We present a simple estimation of the nucleation barrier in slab geometry both in the two dimensional case and in the three dimensional case. We extend the model in the case of rough surfaces which is closer to the experimental case and allows comparison with experimental datas.Comment: 6 pages, 3 figures, Submitted to J. Phys. : Condens. Matter, Proceedings of the IV Liquid Matter Conference - Grenada(Spain) july 199

    Observing Spontaneous Strong Parity Violation in Heavy-Ion Collisions

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    We discuss the problem of observing spontaneous parity and CP violation in collision systems. We discuss and propose observables which may be used in heavy-ion collisions to observe such violations, as well as event-by-event methods to analyze the data. Finally, we discuss simple monte-carlo models of these CP violating effects which we have used to develop our techniques and from which we derive rough estimates of sensitivities to signals which may be seen at RHIC

    Quantum Field Theory of Meson Mixing

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    We have developed a quantum field theoretic framework for scalar and pseudoscalar meson mixing and oscillations in time. The unitary inequivalence of the Fock space of base (unmixed) eigenstates and the physical mixed eigenstates is proven and shown to lead to a rich condensate structure. This is exploited to develop formulas for two flavor boson oscillations in systems of arbitrary boson occupation number. The mixing and oscillation can be understood in terms of vacuum condensate which interacts with the bare particles to induce non-trivial effects. We apply these formulas to analyze the mixing of η\eta with η\eta' and comment on the KLKSK_L K_S system. In addition, we consider the mixing of boson coherent states, which may have future applications in the construction of meson lasers.Comment: 12 pages, 3 figures; Eqs.(10-12) corrected, leading to new physical insights; added paragraph under Eq.(24) explaining physical interpretation of mixing in terms of vacuum condensation; references added and minor typo correcte

    Boundary lubrication with a glassy interface

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    Recently introduced constitutive equations for the rheology of dense, disordered materials are investigated in the context of stick-slip experiments in boundary lubrication. The model is based on a generalization of the shear transformation zone (STZ) theory, in which plastic deformation is represented by a population of mesoscopic regions which may undergo non affine deformations in response to stress. The generalization we study phenomenologically incorporates the effects of aging and glassy relaxation. Under experimental conditions associated with typical transitions from stick-slip to steady sliding and stop start tests, these effects can be dominant, although the full STZ description is necessary to account for more complex, chaotic transitions
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