Medical Encounters and Exchange in Early Canadian Missions

The exchange of medical and pharmaceutical knowledge was an important facet of the encounter between native and newcomer in early Canada. Throughout New France Récollet and Jesuit missionaries were given privileged access both to indigenous peoples and indigenous plants. Curiously, however, when it came to describing medical treatments, it was people, rather than medicinal plants, that were targets of what might be called “the descriptive enterprise.” Attempting to divide suspect shamanic remedies from those deemed natural, missionary observers carefully documented the context of medical treatments rather than simply the specific remedy applied for treatment. Using records left by early Canadian missionaries this paper will look at the peculiar character of medical exchange in the missions of seventeenth and eighteenth-century New France to look at the interpersonal encounters that formed a constitutive element of colonial botany and framed the way in which indigenous knowledge was represented to metropolitan audiences.L’échange de connaissances médicales et pharmaceutiques est une facette importante de la rencontre entre autochtones et nouveaux arrivants en Nouvelle-France. Récollets et Jésuites bénéficient d’un accès également priviligié à la population autochtone et aux plantes indigènes. Curieusement, au moment de décrire les traitements médicaux, ce sont uniquement les personnes et non les plantes médicinales qui sont au centre de ce qu’on pourrait appeler « l’entreprise descriptive ». Tentant de séparer les remèdes chamaniques jugés suspects des remèdes considérés naturels, les missionnaires documentent soigneusement le contexte entourant le traitement médical au lieu de simplement décrire le médicament utilisé. À partir des traces laissées par les premiers misionnaires canadiens, cet article se penche sur le caractère particulier des échanges médicaux dans les missions de la Nouvelle-France du 17e et 18e siècle pour étudier les échanges interpersonnels qui sont un élément constitutif de la botanique coloniale et qui ont façonné la manière selon laquelle les audiences métropolitaines se représentent le savoir indigène

Digital technologies for supporting the informed consent of children and young people in research: the potential for transforming current research ethics practice

Much research at the intersection of technology and ethics focuses on the impact of technological developments and innovation on wider society. This discussion considers the intersection of ethics and technology from the opposite direction; that is, how technology itself can support the ethical participation of people – particularly children and young people – in research. Our central argument is that the use of digital technologies (laptops, PCs, tablet devices, smartphones) offers the potential to support the presentation of information about research topics and methodologies, and children’s decision-making about their own participation, more effectively than by traditional, often paper-based, methods

A new methodology for the quantitative visualization of coherent flow structures in alluvial channels using multibeam echo-sounding (MBES)

In order to investigate the interactions between turbulence and suspended sediment transport in natural aqueous environments, we ideally require a technique that allows simultaneous measurement of fluid velocity and sediment concentration for the whole flow field. Here, we report on development of a methodology using the water column acoustic backscatter signal from a multibeam echo sounder to simultaneously quantify flow velocities and sediment concentrations. The application of this new technique is illustrated with reference to flow over the leeside of an alluvial sand dune, which allows, for the first time in a field study, quantitative visualization of large-scale, whole flow field, turbulent coherent flow structures associated with the dune leeside that are responsible for suspending bed sediment. This methodology holds great potential for use in a wide range of aqueous geophysical flows

Understanding Learning Outcome Divide in the Learning Process from a Teachers Perspective: A BYOD Case Study

Technology-mediated learning has established itself as a valuable pathway towards learners’ academic and social development. However, within the adoption stages of ICT enabled education further questions have been raised in terms of equity of information literacy and learning outcomes. For the last three years, we have been working with one of the earliest secondary schools in New Zealand to introduce a Bring Your Own Device (BYOD) policy. In this paper, we have explored how the information literacy, computer self-efficacy and nature of technology usage are transforming school and classroom curriculum practices. Our analysis reveals changes in boundaries between formal and informal learning spaces with one-to-one devices providing the link between school and home, teachers being transformed to facilitators as students take more ownership of their own learning and how technology is shaping classroom activities which further influence learning outcomes which are known to result in digital outcome divides

I'll be dead by the time it happens: Children's Perceptions of Climate Change in the Mekong Delta, Vietnam

The Mekong Delta in Southern Vietnam is one of the most at risk places globally to the effects of climate change and sea level rise, specifically in terms of flooding. It is predicted to change drastically over the next 100 years, with additional human-driven actions (such as sand mining and groundwater extraction) expected to exasperate the speed and severity of said change. Understanding the existing perceptions of those that will face these future challenges, and what contributes to forming those perceptions, is a critical underpinning required for the success of any future resilience and mitigation initiatives. A holistic view that takes account of these varying influences on societal perceptions, resilience and education needs to be taken. One of the most vulnerable groups to the consequences of climate change, and indeed the citizens that will go on to tackle the majority of challenges we are predicted to face in the future, is children. For this reason alone, ascertaining their perceptions and understandings, along with the influences and sources that shape their views, is paramount.This paper will present the findings from a project that explored local children’s perceptions of climate change in the heart of the Mekong Delta. Creative and arts-based methods enabled children’s voices to be heard. Combined with further policy analysis and interviews with parents, teachers and government officials, these voices have been further contextualised within their socio-cultural context and environment. Through developing an understanding of these perceptions and the influencing factors, a more effective and holistic approach to shaping children’s climate change resilience can be executed, which will ultimately enhance a society’s ability to adapt to and mitigate the impacts of climate change into the future

KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts

The human genome contains microRNAs (miRNAs), small noncoding RNAs that orchestrate a number of physiologic processes through regulation of gene expression. Burgeoning evidence suggests that dysregulation of miRNAs may promote disease progression and cancer pathogenesis. Virus-encoded miRNAs, exhibiting unique molecular signatures and functions, have been increasingly recognized as contributors to viral cancer pathogenesis. A large segment of the existing knowledge in this area has been generated through characterization of miRNAs encoded by the human gamma-herpesviruses, including the Kaposi's sarcoma-associated herpesvirus (KSHV). Recent studies focusing on KSHV miRNAs have led to a better understanding of viral miRNA expression in human tumors, the identification of novel pathologic check points regulated by viral miRNAs, and new insights for viral miRNA interactions with cellular (“human”) miRNAs. Elucidating the functional effects of inhibiting KSHV miRNAs has also provided a foundation for further translational efforts and consideration of clinical applications. This paper summarizes recent literature outlining mechanisms for KSHV miRNA regulation of cellular function and cancer-associated pathogenesis, as well as implications for interactions between KSHV and human miRNAs that may facilitate cancer progression. Finally, insights are offered for the clinical feasibility of targeting miRNAs as a therapeutic approach for viral cancers

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease

This review describes the preclinical mechanisms that may underlie the increased therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor antagonist, memantine, and an acetylcholinesterase inhibitor (AChEI)—for the treatment of Alzheimer’s disease (AD). Memantine, and the AChEIs target two different aspects of AD pathology. Both drug types have shown significant efficacy as monotherapies for the treatment of AD. Furthermore, clinical observations indicate that their complementary mechanisms offer superior benefit as combination therapy. Based on the available literature, the authors have considered the preclinical mechanisms that could underlie such a combined approach. Memantine addresses dysfunction in glutamatergic transmission, while the AChEIs serve to increase pathologically lowered levels of the neurotransmitter acetylcholine. In addition, preclinical studies have shown that memantine has neuroprotective effects, acting to prevent glutamatergic over-stimulation and the resulting neurotoxicity. Interrelations between the glutamatergic and cholinergic pathways in regions of the brain that control learning and memory mean that combination treatment has the potential for a complex influence on disease pathology. Moreover, studies in animal models have shown that the combined use of memantine and the AChEIs can produce greater improvements in measures of memory than either treatment alone. As an effective approach in the clinical setting, combination therapy with memantine and an AChEI has been a welcome advance for the treatment of patients with AD. Preclinical data have shown how these drugs act via two different, but interconnected, pathological pathways, and that their complementary activity may produce greater effects than either drug individually

Prevalence and impact of chronic widespread pain in the Bangladeshi and White populations of Tower Hamlets, East London

The prevalence and impact of chronic pain differ between ethnic groups. We report a study of the comparative prevalence and impact of chronic pain in Bangladeshi, British Bangladeshi and White British/Irish people. We posted a short questionnaire to a random sample of 4,480 patients registered with 16 general practices in the London Borough of Tower Hamlets and conducted a longer questionnaire with patients in the waiting areas at those practices. We distinguished between Bangladeshi participants who were born in the UK or had arrived in the UK at the age of 14 or under (British Bangladeshi) and those who arrived in UK at the age of over 14 (Bangladeshi). We obtained 1,223/4,480 (27 %) responses to the short survey and 600/637 (94 %) to the long survey. From the former, the prevalence of chronic pain in the White, British Bangladeshi and Bangladeshi groups was 55, 54 and 72 %, respectively. The corresponding figures from the long survey were 49, 45 and 70 %. Chronic widespread pain was commoner in the Bangladeshi (16 %) than in the White (10 %) or British Bangladeshi (9 %) groups. People with chronic pain experienced poorer quality of life (odds ratio for scoring best possible health vs. good health (or good vs. poor health) 5.6 (95 % confidence interval 3.4 to 9.8)), but we found no evidence of differences between ethnic groups in the impact of chronic pain on the quality of life. Chronic pain is commoner and, of greater severity, in Bangladeshis than in Whites. On most measures in this study, British Bangladeshis resembled the Whites more than the Bangladeshis

Mismeasured Mortality: Correcting Estimates of Wolf Poaching in the United States

Measuring rates and causes of mortalities is important in animal ecology and management. Observing the fates of known individuals is a common method of estimating life history variables, including mortality patterns. It has long been assumed that data lost when known animals disappear were unbiased. We test and reject this assumption under conditions common to most, if not all, studies using marked animals. We illustrate the bias for 4 endangered wolf populations in the United States by reanalyzing data and assumptions about the known and unknown fates of marked wolves to calculate the degree to which risks of different causes of death were mismeasured. We find that, when using traditional methods, the relative risk of mortality from legal killing measured as a proportion of all known fates was overestimated by 0.05–0.16 and the relative risk of poaching was underestimated by 0.17–0.44. We show that published government estimates are affected by these biases and, importantly, are underestimating the risk of poaching. The underestimates have obscured the magnitude of poaching as the major threat to endangered wolf populations. We offer methods to correct estimates of mortality risk for marked animals of any taxon and describe the conditions under which traditional methods produce more or less bias. We also show how correcting past and future estimates of mortality parameters can address uncertainty about wildlife populations and increase the predictability and sustainability of wildlife management interventions