10 research outputs found
Barriers of Womenâs Participation in Intramurals
Although there are many positive benefits in participating in intramural sports, there seems to be a lack of participation and commitment for women in comparison to men. Exploring womenâs opinions and feelings towards intramural sports may help us to understand what certain barriers may restrict their participation and factors that may increase their participation. Therefore, the purpose of this research was to investigate the barriers of womenâs participation in intramurals, specifically third and fourth-year female students at the University of British Columbia (UBC). Men were included in the research to determine any significant differences between the two genders. Through an online survey, data was collected from 57 participants including 38 women, 17 men and 2 who preferred not to answer. The survey consisted of a Likert Scale based upon their opinions on intramurals, as well as including open-ended questions for any participants that wanted to provide their feedback. Results showed that the participants acknowledged the health benefits that intramurals sport offer. However, barriers such as social support, competency, time constraints, and promotional awareness seem to be the most effective in their participation. To our surprise, a new barrier has been discovered within our research that the mode of transportation also contributed to their decision of joining intramural sports. Furthermore, it appears that the number of women or men within an intramural team did not have a significant impact on influencing womenâs choice of participating. From our open-ended questions, participants provided recommendations on how to increase the participation of women in intramurals. There were a few that suggested there should be more effective promotion strategies to the student population, especially to the female students. Additionally, implementing a fix-hour within certain days of the week for students or even providing prizes for those who participate in intramurals could be beneficial in increasing the rates of women participating. Moving forward, further research should focus primarily on women, as well as expanding the sample size to get more variety of opinions, answers, and suggestions. Considering that there are many international students and students from other institutions that transfer to UBC in their third and fourth years, these should be examined in further research to gain a better understanding if transferring to a new institution can be a potential barrier. The exploration of the barriers and motivation of participants at UBC who took part in this study will help in future research and increase knowledge around women's participation in intramural sports and expand programming resources to help create new recreation programs. With these suggestions, this could help to find different avenues to increase womenâs participation in intramurals in the future for UBC and other institutions. Disclaimer: âUBC SEEDS provides students with the opportunity to share the findings of their studies, as well as their opinions, conclusions and recommendations with the UBC community. The reader should bear in mind that this is a student project/report and is not an official document of UBC. Furthermore readers should bear in mind that these reports may not reflect the current status of activities at UBC. We urge you to contact the research persons mentioned in a report or the SEEDS Coordinator about the current status of the subject matter of a project/report.âEducation, Faculty ofKinesiology, School ofUnreviewedUndergraduat
Accelerating Convergence in Molecular Dynamics Simulations of Solutes in Lipid Membranes by Conducting a Random Walk along the Bilayer Normal
All
molecular dynamics simulations are susceptible to sampling
errors, which degrade the accuracy and precision of observed values.
The statistical convergence of simulations containing atomistic lipid
bilayers is limited by the slow relaxation of the lipid phase, which
can exceed hundreds of nanoseconds. These long conformational autocorrelation
times are exacerbated in the presence of charged solutes, which can
induce significant distortions of the bilayer structure. Such long
relaxation times represent hidden barriers that induce systematic
sampling errors in simulations of solute insertion. To identify optimal
methods for enhancing sampling efficiency, we quantitatively evaluate
convergence rates using generalized ensemble sampling algorithms in
calculations of the potential of mean force for the insertion of the
ionic side chain analog of arginine in a lipid bilayer. Umbrella sampling
(US) is used to restrain solute insertion depth along the bilayer
normal, the order parameter commonly used in simulations of molecular
solutes in lipid bilayers. When US simulations are modified to conduct
random walks along the bilayer normal using a Hamiltonian exchange
algorithm, systematic sampling errors are eliminated more rapidly
and the rate of statistical convergence of the standard free energy
of binding of the solute to the lipid bilayer is increased 3-fold.
We compute the ratio of the replica flux transmitted across a defined
region of the order parameter to the replica flux that entered that
region in Hamiltonian exchange simulations. We show that this quantity,
the transmission factor, identifies sampling barriers in degrees of
freedom orthogonal to the order parameter. The transmission factor
is used to estimate the depth-dependent conformational autocorrelation
times of the simulation system, some of which exceed the simulation
time, and thereby identify solute insertion depths that are prone
to systematic sampling errors and estimate the lower bound of the
amount of sampling that is required to resolve these sampling errors.
Finally, we extend our simulations and verify that the conformational
autocorrelation times estimated by the transmission factor accurately
predict correlation times that exceed the simulation time scaleîžsomething
that, to our knowledge, has never before been achieved