Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

This work was supported by a restricted research grant of Bayer AG

Generation of high-power spatially structured beams using vertical external cavity surface emitting lasers

In this paper, we demonstrate the generation of high-power and spatially structured beams using vertical external cavity surface emitting lasers (VECSEL). At the fundamental wavelength, an intracavity mode-control element is first employed to generate a range of Hermite-Gaussian (HG) modes in a linear cavity. The same HG modes are then excited and frequency doubled in a V-cavity geometry to generate a rich variety of high-power spatially structured beams. The results compare well with our numerical modeling. (C) 2017 Optical Society of AmericaECCS Division of National Science Foundation (NSF); State of Arizona Technology and Research Initiative Funding (TRIF)Open access journal.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

High peak power, sub-ps green emission in a passively mode locked W-cavity VECSEL

We report on the experimental results of a passively mode-locked vertical external cavity surface emitting laser (VECSEL), implemented in a W-cavity configuration, using a lithium triborate (LBO) crystal for intra-cavity second harmonic generation (SHG) at 528 nm. The W-cavity configuration allows separation of the crystal from the semiconductor saturable absorber mirror (SESAM), enabling independent control over the Gaussian beam sizes at the crystal, chip, and SESAM. This optimized cavity demonstrated a second harmonic pulse width of similar to 760 fs at a frequency of 465 MHz and 230 mW average output power, resulting in a peak pulse power of 580 W. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing AgreementOpen access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

High power two-color orbital angular momentum beam generation using vertical external cavity surface emitting lasers

We report the design and experimental results for a two-chip T-cavity vertical external cavity surface emitting laser utilized for two-color collinear generation of Hermite-Gaussian and LaguerreGaussian (LG) transverse modes. A combination of intracavity mode-control elements and an external astigmatic mode converter was used to achieve high power LG modes. By incorporating intracavity birefringent filters in each arm of the T-cavity, wide wavelength tuning in excess of 12 nm of each mode is demonstrated. Output power exceeding 1.5W is measured for all the modes. Published by AIP Publishing.ECCS Division of National Science Foundation (NSF) [3024880]12 month embargo; published online: 24 January 2018This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Metabolomic profiling to characterize acute intestinal ischemia/reperfusion injury

<div><p>Sepsis and septic shock are the leading causes of death in critically ill patients. Acute intestinal ischemia/reperfusion (AII/R) is an adaptive response to shock. The high mortality rate from AII/R is due to the severity of the disease and, more importantly, the failure of timely diagnosis. The objective of this investigation is to use nuclear magnetic resonance (NMR) analysis to characterize urine metabolomic profile of AII/R injury in a mouse model. Animals were exposed to sham, early (30 min) or late (60 min) acute intestinal ischemia by complete occlusion of the superior mesenteric artery, followed by 2 hrs of reperfusion. Urine was collected and analyzed by NMR spectroscopy. Urinary metabolite concentrations demonstrated that different profiles could be delineated based on the duration of the intestinal ischemia. Metabolites such as allantoin, creatinine, proline, and methylamine could be predictive of AII/R injury. Lactate, currently used for clinical diagnosis, was found not to significantly contribute to the classification model for either early or late ischemia. This study demonstrates that patterns of changes in urinary metabolites are effective at distinguishing AII/R progression in an animal model. This is a proof-of-concept study to further support examination of metabolites in the clinical diagnosis of intestinal ischemia reperfusion injury in patients. The discovery of a fingerprint metabolite profile of AII/R will be a major advancement in the diagnosis, treatment, and prevention of systemic injury in critically ill patients.</p></div

Generation of high-power spatially structured beams using vertical external cavity surface emitting lasers

In this paper, we demonstrate the generation of high-power and spatially structured beams using vertical external cavity surface emitting lasers (VECSEL). At the fundamental wavelength, an intracavity mode-control element is first employed to generate a range of Hermite-Gaussian (HG) modes in a linear cavity. The same HG modes are then excited and frequency doubled in a V-cavity geometry to generate a rich variety of high-power spatially structured beams. The results compare well with our numerical modeling. (C) 2017 Optical Society of AmericaECCS Division of National Science Foundation (NSF); State of Arizona Technology and Research Initiative Funding (TRIF)Open access journal.This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Heat map profile of metabolites from sham and acute intestinal ischemia/reperfusion (AII/R) animals.

<p>There were 57 compounds that were identified in the urine of mice in the sham and AII/R-treated groups. These metabolites belong to a variety of biochemical sub-groups. Metabolite concentrations across all animals were averaged and the resulting difference (± standard deviation; σ) displayed as a color index of red (>mean) or green (</p