Unanswered Questions in the Electroweak Theory

This article is devoted to the status of the electroweak theory on the eve of experimentation at CERN's Large Hadron Collider. A compact summary of the logic and structure of the electroweak theory precedes an examination of what experimental tests have established so far. The outstanding unconfirmed prediction of the electroweak theory is the existence of the Higgs boson, a weakly interacting spin-zero particle that is the agent of electroweak symmetry breaking, the giver of mass to the weak gauge bosons, the quarks, and the leptons. General arguments imply that the Higgs boson or other new physics is required on the TeV energy scale. Indirect constraints from global analyses of electroweak measurements suggest that the mass of the standard-model Higgs boson is less than 200 GeV. Once its mass is assumed, the properties of the Higgs boson follow from the electroweak theory, and these inform the search for the Higgs boson. Alternative mechanisms for electroweak symmetry breaking are reviewed, and the importance of electroweak symmetry breaking is illuminated by considering a world without a specific mechanism to hide the electroweak symmetry. For all its triumphs, the electroweak theory has many shortcomings. . . .Comment: 31 pages, 20 figures; prepared for Annual Review of Nuclear and Particle Science (minor changes

The fear of big brother:The potential negative side-effects of proctored exams

Background: Online and blended learning need an appropriate assessment strategy which ensures academic integrity. During the pandemic, many universities have chosen for online proctoring. Although some earlier examples suggest that online proctoring may reduce cheating, the potential side-effects of proctoring are largely unknown. Objectives: Therefore, this study aims to identify the effects of proctoring on students' self-reported temptation to cheat and potentially undesirable side-effects, including test anxiety, perceived exam difficulty, and performance. In addition, we examine which contextual and student characteristics affect test anxiety during online exams. Methods: For this, we collected four waves of survey data throughout a year of teaching during the pandemic at one faculty of a Dutch university, resulting in a total sample of 1760 students within 105 courses. Results and Conclusions: Multi-level analyses showed that while proctoring had no effect on the temptation to cheat, exam difficulty or performance, students reported higher levels of test anxiety. Some learning strategies, internet literacy, access to a reliable technology and a dedicated study space as well as gender and financial stress affect their test anxiety. To conclude, the decision to use online proctoring needs to consider the undesirable side-effect on test anxiety. We discuss practical implications for university administrators, educational designers and teachers to reduce test anxiety.</p

Do 21st-century skills make you less lonely? The relation between 21st-century skills, social media usage, and students’ loneliness during the COVID-19 pandemic

21st-century skills are a new category of competencies recommended for people to adapt to the digital era. Digital communication skills, particularly, are regarded as an important facet in a progressively moving online society. Empirical evidence of their actual value, however, is largely missing. Recently, the COVID-19 pandemic offered an appropriate testing ground for the possible beneficial role that such skills might play. Our results show that digital communication skills correlate with loneliness. However, social media usage, online contacts, and offline contacts only partially mediate the relationship between digital communication skills and the loneliness levels of students. In addition, we found substantial differences between the two waves of data collection and the types of contacts that influenced loneliness. While skills may have reduced loneliness, the precise mechanism of this effect needs to be clarified more. We offer suggestions for future research to examine the potential benefits of 21st-century skills

Regular Patterns in Cerebellar Purkinje Cell Simple Spike Trains

Background. Cerebellar Purkinje cells (PC) in vivo are commonly reported to generate irregular spike trains, documented by high coefficients of variation of interspike-intervals (ISI). In strong co

One Monopole with k Singularities

We present all charge one monopole solutions of the Bogomolny equation with k prescribed Dirac singularities for the gauge groups U(2), SO(3), or SU(2). We analyze these solutions comparing them to the previously known expressions for the cases of one or two singularities.Comment: 12 pages, LaTe

Training emergency services’ dispatchers to recognise stroke: an interrupted time-series analysis

Background: Stroke is a time-dependent medical emergency in which early presentation to specialist care reduces death and dependency. Up to 70% of all stroke patients obtain first medical contact from the Emergency Medical Services (EMS). Identifying ‘true stroke’ from an EMS call is challenging, with over 50% of strokes being misclassified. The aim of this study was to evaluate the impact of the training package on the recognition of stroke by Emergency Medical Dispatchers (EMDs). Methods: This study took place in an ambulance service and a hospital in England using an interrupted time-series design. Suspected stroke patients were identified in one week blocks, every three weeks over an 18 month period, during which time the training was implemented. Patients were included if they had a diagnosis of stroke (EMS or hospital). The effect of the intervention on the accuracy of dispatch diagnosis was investigated using binomial (grouped) logistic regression. Results: In the Pre-implementation period EMDs correctly identified 63% of stroke patients; this increased to 80% Post-implementation. This change was significant (p=0.003), reflecting an improvement in identifying stroke patients relative to the Pre-implementation period both the During-implementation (OR=4.10 [95% CI 1.58 to 10.66]) and Post-implementation (OR=2.30 [95% CI 1.07 to 4.92]) periods. For patients with a final diagnosis of stroke who had been dispatched as stroke there was a marginally non-significant 2.8 minutes (95% CI −0.2 to 5.9 minutes, p=0.068)reduction between Pre- and Post-implementation periods from call to arrival of the ambulance at scene. Conclusions: This is the first study to develop, implement and evaluate the impact of a training package for EMDs with the aim of improving the recognition of stroke. Training led to a significant increase in the proportion of stroke patients dispatched as such by EMDs; a small reduction in time from call to arrival at scene by the ambulance also appeared likely. The training package has been endorsed by the UK Stroke Forum Education and Training, and is free to access on-line

Self-assembly of Microcapsules via Colloidal Bond Hybridization and Anisotropy

Particles with directional interactions are promising building blocks for new functional materials and may serve as models for biological structures. Mutually attractive nanoparticles that are deformable due to flexible surface groups, for example, may spontaneously order themselves into strings, sheets and large vesicles. Furthermore, anisotropic colloids with attractive patches can self-assemble into open lattices and colloidal equivalents of molecules and micelles. However, model systems that combine mutual attraction, anisotropy, and deformability have---to the best of our knowledge---not been realized. Here, we synthesize colloidal particles that combine these three characteristics and obtain self-assembled microcapsules. We propose that mutual attraction and deformability induce directional interactions via colloidal bond hybridization. Our particles contain both mutually attractive and repulsive surface groups that are flexible. Analogous to the simplest chemical bond, where two isotropic orbitals hybridize into the molecular orbital of H2, these flexible groups redistribute upon binding. Via colloidal bond hybridization, isotropic spheres self-assemble into planar monolayers, while anisotropic snowman-like particles self-assemble into hollow monolayer microcapsules. A modest change of the building blocks thus results in a significant leap in the complexity of the self-assembled structures. In other words, these relatively simple building blocks self-assemble into dramatically more complex structures than similar particles that are isotropic or non-deformable

Vitamin and Mineral Deficiencies Are Highly Prevalent in Newly Diagnosed Celiac Disease Patients

Malabsorption, weight loss and vitamin/mineral-deficiencies characterize classical celiac disease (CD). This study aimed to assess the nutritional and vitamin/mineral status of current “early diagnosed” untreated adult CD-patients in the Netherlands. Newly diagnosed adult CD-patients were included (n = 80, 42.8 ± 15.1 years) and a comparable sample of 24 healthy Dutch subjects was added to compare vitamin concentrations. Nutritional status and serum concentrations of folic acid, vitamin A, B6, B12, and (25-hydroxy) D, zinc, haemoglobin (Hb) and ferritin were determined (before prescribing gluten free diet). Almost all CD-patients (87%) had at least one value below the lower limit of reference. Specifically, for vitamin A, 7.5% of patients showed deficient levels, for vitamin B6 14.5%, folic acid 20%, and vitamin B12 19%. Likewise, zinc deficiency was observed in 67% of the CD-patients, 46% had decreased iron storage, and 32% had anaemia. Overall, 17% were malnourished (>10% undesired weight loss), 22% of the women were underweight (Body Mass Index (BMI) < 18.5), and 29% of the patients were overweight (BMI > 25). Vitamin deficiencies were barely seen in healthy controls, with the exception of vitamin B12. Vitamin/mineral deficiencies were counter-intuitively not associated with a (higher) grade of histological intestinal damage or (impaired) nutritional status. In conclusion, vitamin/mineral deficiencies are still common in newly “early diagnosed” CD-patients, even though the prevalence of obesity at initial diagnosis is rising. Extensive nutritional assessments seem warranted to guide nutritional advices and follow-up in CD treatment